I doubt you speak from personal experience in the air force.
What is a 'determined' enemy? it is a meaningless phrase. The default position is that all enemies are determined regardless of how much weapons they have, how many soldiers/airmen/sailors available, and so on. We
CANNOT assume that the enemy is any less determined to defend than we are to attack. So your statement is meaningless to start.
But as far as the USAF go, if your airbase is designated, we
WILL make it there. In the image above, one B-2 dropped six bombs at the Obvra airbase runway. The four runway-taxiway intersections were cratered to prevent aircraft movements. The two other craters neatly dissected the runways into segments too short to use by any aircraft except for helos. The result is that the runways will be out of operation for at least 1/2 day. In that time, we will see no threat from that base. The mission is called
'runway denial'. There is a science to this. Just because Iran does not have that knowledge does not mean no one else does.
A flying base without a functional runway is useless. Everything on a flying base is there to support the aircrafts. But if the runway is damaged, the entire base is useless. We can destroy runways, simple as that.
