To be honest, 'DISPROVAL' in science is also somewhat based on few assumptions:
https://undsci.berkeley.edu/article/basic_assumptions
With these assumptions only you work. So, to be honest, disproval of some explaination is also based on assumption that laws of nature are consistent. If some of them are not, then all bets are off.
The issue with 'Almighty' is that the way you define it, makes it impossible -- by design I guess? -- to construct any experiment that can prove or disprove its existence.