Real-time update on coronavirus outbreak

[riscol]

Just as WHO said earlier China has reacted rapidly otherwise the virus would have spread much faster with higher number of infected and fatality cases. Both numbers are certainly going to rise but containment is already doing its job by keeping the spreading of the virus as small as possible. Fighting it is much more important than talking about taking advantages of the current situation like that Wilbur Ross.

 

[tower9]

Just as WHO said earlier China has reacted rapidly otherwise the virus would have spread much faster with higher number of infected and fatality cases. Both numbers are certainly going to rise but containment is already doing its job by keeping the spreading of the virus as small as possible. Fighting it is much more important than talking about taking advantages of the current situation like that Wilbur Ross.

The reaction of the Trump administration and the words chosen by many of his officials just makes fuels the speculation that this was a planned hit.

I don't buy the garbage that this comes from bat soup. Most Chinese never even heard of that until this occurred.

 

[lcloo]

Today's Update

Data collected indicate that the majority of deaths are people of age 60 and above, and had chronic sickness, people with weak immunity system.

Quote from Henri Kenhmann/ East Pendulum:-
En ce moment difficile, pas de propagation de rumeur, pas de pseudo-expert et pas d’analyse « politiquement correct ».

At this difficult time, no rumour spread, no pseudo-expert and no "political correct" analysis.

 

[lcloo]

Google Translate
Changjiang Daily - Reports from Huazhong University of Science and Technology, Huazhong University of Science and Technology Tongji Medical College, Huazhong University of Science and Technology Tongji Medical College affiliated Wuhan Children's Hospital scholars jointly Xi'an Jiaotong University First Affiliated Hospital, Chinese Academy of Sciences Beijing Genomics Research Institute, Huawei Cloud Research Team announced that, Five antiviral drugs that may be effective for the new coronavirus (2019-nCoV) were screened.

It is reported that the above-mentioned joint scientific research team for the 2019 new coronavirus of a number of target proteins (of which Mpro protein crystal structure provided by the Chinese Academy of Sciences Raoko and academician team), 8506 drugs on the market or in the ongoing clinical trials in the ultra-large-scale computer-aided drug screening work, and achieved the first phase in a week.

The study found that five drugs may be effective for the 2019 new coronavirus: Beclabuvir, Saquinavir, Bictegravir, Lopinavir and Dolutegravir

The joint team found that Beclabuvir not only binds to the Mpro protein, but may also be a potential inhibitor of the RNA polymerase NSP12 of the 2019 new coronavirus RNA dependence, and saquinavir not only binds well to the Mpro protein. It can also be combined with the S protein of the 2019 new coronavirus, which can prevent the virus from amplifying both inside the cell and on the surface.

It is understood that at present, the joint scientific research team is on the above five antiviral drugs for cytological verification, and promote clinical trials of drugs. The research results released by the joint research team will be open to biomedical research institutions through Huawei Cloud for antiviral drug research and development.

除了李兰娟团队成果 武汉还有好消息：5种药物可能有效
2020年02月04日 23:53:57
来源：长江日报

806人参与71评论


长江日报-长江网记者4日从华中科技大学获悉，2月3日，华中科技大学同济医学院、华中科技大学同济医学院附属武汉儿童医院学者联合西安交通大学第一附属医院、中科院北京基因组研究所、华为云科研团队宣布，筛选出五种可能对2019新型冠状病毒（2019-nCoV）有效的抗病毒药物。

据悉，上述联合科研团队针对2019新型冠状病毒的多个靶标蛋白（其中Mpro 蛋白晶体结构由中科院饶子和院士团队提供），对8506种上市或者正在进行临床试验的药物中进行超大规模计算机辅助药物筛选工作，并在一周内取得了第一阶段成果。

研究发现，有五种药物可能对2019新型冠状病毒有效，分别是 Beclabuvir，沙奎那韦（Saquinavir），比特拉韦（Bictegravir），洛匹那韦（Lopinavir），多替拉韦（Dolutegravir） 。

联合科研团队发现，Beclabuvir不仅可以和Mpro蛋白结合，还可能是2019新型冠状病毒RNA依赖的RNA聚合酶NSP12的一种潜在抑制剂；沙奎那韦（Saquinavir）不仅可以很好地同Mpro蛋白结合，还能够和2019新型冠状病毒的S蛋白相结合，可以同时在细胞内部和表面阻止病毒的扩增。

据了解，目前，联合科研团队正在对上述五种抗病毒药物进行细胞学验证，并推动药物临床实验。本次联合科研团队发布的研究成果都将通过华为云面向生物医药研究机构开放，用于抗病毒药物研发。


Another news on two drugs deemed to be more effective after research results, these 2 drugs will replace current ones used for Coronavirus treatments.
Major achievements of Li Lanxuan's team: Abidore and Dalunawe can effectively suppress coronaviruses
Tuesday, February 4, 2020 5:23:15 PM

Changjiang Daily - Changjiang Daily - Changjiang Network February 4 (Reporter Huang Qi) 4, the Chinese Academy of Engineering, the National Health and Health Commission high-level expert group member Li Lanxuan team, in Wuhan announced the treatment of new coronary virus infection pneumonia latest research results.

According to preliminary tests, in vitro cell experiments showed:
(1) Abigail at 10 to 30 micromolar concentration, compared with the drug untreated control group, can effectively inhibit coronavirus up to 60 times, and significantly inhibit the virus on the cell lesions effect.
(2) Dalunavir at a concentration of 300 micromoles, can significantly inhibit viral replication, compared with the unused drug treatment group, inhibition efficiency of 280 times.

Li Lanxuan said that the anti-AIDS drug Crech on the treatment of new coronary virus infection pneumonia effect is not good, and toxic side effects. She recommended that the two drugs be included in the National Health and Reform Commission's Pneumonia Treatment Programme for New Coronary Virus Infections (Trial Sixth Edition).

Li Lanxuan academician team members, Zhejiang Aid E'o intensive care team leader, Zhejiang University, the first hospital vice president Chen Zubing reminded, "These two drugs are prescription drugs, patients must be under the guidance of the doctor to take." He also said that the two drugs are now used in patients with pneumonia with the new coronavirus infection in Zhejiang Province, and the next step is to replace other less effective drugs with these drugs.

李兰娟院士团队重大成果：阿比朵尔、达芦那韦能有效抑制冠状病毒
2020年02月04日 17:23:15

长江日报-长江网2月4日讯（记者黄琪）4日，中国工程院院士、国家卫健委高级别专家组成员李兰娟团队，在武汉公布治疗新型冠状病毒感染的肺炎的最新研究成果。

李兰娟院士说，根据初步测试，在体外细胞实验中显示：（1）阿比朵尔在10～30微摩尔浓度下，与药物未处理的对照组比较，能有效抑制冠状病毒达到60倍，并且显著抑制病毒对细胞的病变效应。（2）达芦那韦在300微摩尔浓度下，能显著抑制病毒复制，与未用药物处理组比较，抑制效率达280倍。

李兰娟院士说，抗艾滋病药物克力芝对治疗新型冠状病毒感染的肺炎效果不佳，且有毒副作用。她建议将以上两种药物列入国家卫健委《新型冠状病毒感染的肺炎诊疗方案(试行第六版)》。

李兰娟院士团队成员、浙江援鄂重症救治组领队、浙大一院副院长陈作兵提醒，“这两种药为处方药，患者一定要在医生的指导下服用。”他还介绍，现在这两种药物已经在浙江省新型冠状病毒感染的肺炎患者中使用，下一步计划用这两种药物替代其他效果欠佳的药物。

 

[riscol]

US bio warfare against China based on all the evidence gathered. China knows about it, best of luck defeating the virus

 

[tower9]

US bio warfare against China based on all the evidence gathered. China knows about it, best of luck defeating the virus

Of course they know about it. That's why they set the country on a war footing to combat it. They won't announce it to the public however because that would essentially put the US and China in an open war footing during a period where China can't challenge the US yet.

 

[striver44]

This can not prove this virus is more deadly than SARS. Matter of fact, it is the contrary. SARS affects young people and the elderly alike, and a lot of young people died, while this virus mainly cause severe symptoms among the elderly and those with chronic illnesses, and the deaths are mainly among those people. Same case for flu in the US which has resulted in over 6,000 deaths so far, but you can not say flu is more deadly than SARS either.

And I notice there is two good trend:
The rate of increasing in suspected cases is getting slower, and the number of people get cured are increasing rapidly. This means we will see a turning point in the coming one or two weeks which will show this epidemic is getting under control.

In 5 days (at this rate)the number of deaths will surpass the mers dan sars.

Despite New Hospital and new Quarantine installation and way more Doctors/Nurses... Deaths per day is increasing... Cases per day is increasing etc...
I wonder what are the real numbers...

The CCP will never allow the real number to come out. Strange that they ask for foreign help,arresting doctors if the death is only at 490+

 

[Kai Liu]

In 5 days (at this rate)the number of deaths will surpass the mers dan sars.

The CCP will never allow the real number to come out. Strange that they ask for foreign help,arresting doctors if the death is only at 490+

You have to look at who died out of this epidemic. For SARS, it affects the young and the elderly alike, a lot of young people died, while for this virus, vast majority of those who died were on their 80s or even older, or those who had chronic illnesses. Number of death is not the only measure of the severeness of an epidemic, otherwise, the flu in America in which 10,000+ died so far will be far more dangerous, but it is not.
There are several good news: #1, the number of people get cured are shooting up, we will see hundreds and even thousands people get recovered each day very soon, and this epidemic will be over in coming weeks.
#2, the number of suspected cases are growing slower and slower, which means the number of confirmed cases each day will drop soon as a result of the delay effect.
#3, the confirmed cases outside Hubei province each day are decreasing, which means the epidemic is getting under control outside Wuhan/Hubei, and then within Wuhan/Hubei.

And let's not get this too political. It is an epidemic which dose happen everywhere, and could affect the entire human kind.

 

[tower9]

You have to look at who died out of this epidemic. For SARS, it affects the young and the elderly alike, a lot of young people died, while for this virus, vast majority of those who died were on their 80s or even older, or those who had chronic illnesses. Number of death is not the only measure of the severeness of an epidemic, otherwise, the flu in America in which 10,000+ died so far will be far more dangerous, but it is not.
There are several good news: #1, the number of people get cured are shooting up, we will see hundreds and even thousands people get recovered each day very soon, and this epidemic will be over in coming weeks.
#2, the number of suspected cases are growing slower and slower, which means the number of confirmed cases each day will drop soon as a result of the delay effect.
#3, the confirmed cases outside Hubei province each day are decreasing, which means the epidemic is getting under control outside Wuhan/Hubei, and then within Wuhan/Hubei.

And let's not get this too political. It is an epidemic which dose happen everywhere, and could affect the entire human kind.

It's not happening everywhere. 99% of the impact is on China and it is destabilizing China's economy and isolating it. Clearly, there is a strong argument that there were political motives behind this, that this was not a naturally occurring virus.

Also I've read that the mechanism of this virus binds to lung receptors that are uniquely 5x more expressed among Asians than among other races. Is there proof that Caucasians or non-Asians have been infected with the Coronavirus? Pretty suspicious. Everything points to a CIA bioweapon and possibly even designed with a racial component. The CIA is the world's biggest mafia so this is all not implausible.

 

[Viet]

Now the people in Hanoi get panicked buying supermarkets empty.

Thank you China

Depleted vegetable shelves at a supermarket in Tran Dang Dinh Street on February 3, 2020. Photo by VnExpress/Pham Nga.

 

[striver44]

https://twitter.com/x/status/1225011679592771589

https://twitter.com/x/status/1225058059401289728

@Kai Liu

 

[kankan326]

https://twitter.com/x/status/1225011679592771589

https://twitter.com/x/status/1225058059401289728

@Kai Liu

There is only one data source: Chinese government. Tencent as a company doesn't have access to the "real data".

 

[striver44]

There is only one data source: Chinese government. Tencent as a company doesn't have access to the "real data".

Why would i be surprised? every media in PRC is controlled by the CCP , just one media doesn't mean its false. Leaks do happen
And from history we do know that communist ruling party had this paranoia of not getting everyrhing under control..

10 years from now HBO should make a mini series about Wuhan just like what they do with chernobyl.

 

[kankan326]

Why would i be surprised? every media in PRC is controlled by the CCP , just one media doesn't mean its false. Leaks do happen
And from history we do know that communist ruling party had this paranoia of not getting everyrhing under control..

10 years from now HBO should make a mini series about Wuhan just like what they do with chernobyl.

Nobody wanted you to be surprised. Tencent is not capable to collect the data even if government allows it to do it. Only government has the power to do such big scale work. It has nothing to do with political system.

 

[Kai Liu]

https://twitter.com/x/status/1225011679592771589

https://twitter.com/x/status/1225058059401289728

@Kai Liu

This is such a fake shxt...
If this is the case, places outside Hubei/Wuhan would have thousands of death by now too, but from my personal experience, where I live and work in a place with tens of thousands of employees, I never heard anyone get infected, let alone death... Nowadays, information passed very fast, you can not hide anything.
The only authentic info is from the Chinese government or WHO. Tencent is never an official source, let alone it is from some B.S. media from tw or some nobody's twitter or somthing...

BTW, if that is the 'true' figure, I believe the 'true' figure outside the country would be 10x times higher as well, and there would be hundreds of deaths by now, but it does not happen.

This kind of B.S. can only fool those with very very low IQs...