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Clinical human trials begin for COVID-19 vaccine in China

NEWS RELEASE 24-JUL-2020
Another mRNA-based vaccine candidate protects animals against SARS-CoV-2 | EurekAlert! Science News
CELL PRESS

An experimental messenger RNA (mRNA)-based vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) elicits protective immune responses in mice and non-human primates, researchers report on July 23rd in the journal Cell. Two injections of the vaccine were sufficient to induce robust immunity, completely preventing SARS-CoV-2 infection in mice.

"The robust protection observed in the present studies and the clear immune correlates of protection pave the path forward for future COVID-19 vaccine development in humans," says senior study author Cheng-Feng Qin of the Beijing Institute of Microbiology and Epidemiology.

mRNA-based vaccines are attractive options for protecting against SARS-CoV-2 because they can be rapidly designed and manufactured at a large scale within weeks. Moreover, preclinical studies have demonstrated that mRNA-based vaccines induce potent and broadly protective immune responses against various pathogens with an acceptable safety profile.

In the Cell study, Qin and his colleagues developed a vaccine consisting of mRNA that encodes the receptor-binding domain (RBD) of the spike (S) protein, which is located on the surface of SARS-CoV-2. The vaccine, named ARCoV, is encapsulated in lipid nanoparticles, which improves delivery into tissues.

Targeting RBD rather than the entire S protein may represent a safer option, potentially triggering the production of fewer non-neutralizing antibodies. These antibodies could enhance viral entry into cells and viral replication through a process called antibody-dependent enhancement of infection, which has been previously reported for the related virus SARS-CoV--the causative agent of the SARS outbreak in 2002 to 2003.

The researchers injected ARCoV into the muscle tissue of 16 mice and provided a booster shot two weeks later. The vaccine elicited the production of high levels of neutralizing antibodies, which protect host cells by preventing the virus from interacting with them. These antibodies were cross-reactive, offering broad protection against three different strains of SARS-CoV-2. In addition, the vaccine increased the number of T cells in the spleen.

Mice that received two doses of ARCoV and were exposed to SARS-CoV-2 35 days later showed no signs of viral RNA in the lungs or trachea and no lung damage or inflammation. Results from 20 cynomolgus monkeys showed that two ARCoV doses induced a virus-specific T cell response and the production of neutralizing antibodies at levels that far exceed those seen in most recovered COVID-19 patients. Moreover, none of the vaccinated animals experienced adverse effects.

To assess the thermal stability of ARCoV, the researchers stored the vaccine at various temperatures for one, four, or seven days, injected it into mice, and visualized its tissue distribution. The results showed that the vaccine was effectively delivered to tissues, achieving the same high level of expression after being stored at room temperature for one week, without any signs of decreased activity. "A ready-to-use and thermostable vaccine like ARCoV is highly desirable to eliminate the need for cold-chain transportation," Qin says.

The researchers are currently evaluating the long-term stability of ARCoV. "In addition, the duration of neutralization antibody induced by ARCoV is yet to be determined, as experience from other human coronaviruses has indicated the possibility of re-infection due to waning of the antibody response," Qin says. "Future studies are needed to evaluate the long-term immune response in animal models and the effectiveness of ARCoV in humans."


China starts building COVID-19 vaccine production facility
Source: Xinhua| 2020-12-21 20:29:20|Editor: huaxia

KUNMING, Dec. 21 (Xinhua) -- China started the construction on Monday of a plant for manufacturing an mRNA-based COVID-19 vaccine, with production operations due to begin in eight months, according to local authorities.

The facility in the city of Yuxi, in southwest China's Yunnan Province, is expected to produce 120 million doses per year in its first phase, with key manufacturing equipment and core ingredients all independently developed by China.

The vaccine was approved by the National Medical Products Administration for clinical drug trials on June 19, 2020, and is about to enter phase-II clinical trials.

It was jointly developed by the Academy of Military Medical Sciences, Suzhou Abogen Biosciences and Yunnan-based Walvax Biotechnology Co., Ltd.

In phase-I clinical trials, the vaccine was shown to be safe with good immunogenicity, and it has excellent stability in storage at 2-8 degrees Celsius, according to the vaccine developers.

The mRNA in the vaccine enters human cells and expresses antigens, which induces the immune system to respond so that the body can obtain immunity.
 
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18:49, 23-Dec-2020
Phase 3 trials of Chinese COVID-19 vaccine start in Uzbekistan
CGTN

76e840f6e38e4cac895469409fa6c614.png
People wearing face masks wait in line to enter the grocery store amid the COVID-19 outbreak in Tashkent, Uzbekistan April 9, 2020. /Reuters

Late-stage clinical trials of a Chinese candidate coronavirus vaccine has been carried out in Uzbekistan on Tuesday after early and mid-stage results suggest it is safe and efficient, researchers said.

The ZF2001 vaccine, which uses a harmless piece of the virus to induce the human body's immune response, is one of China's five candidate vaccines that have entered human trials overseas.

"We are planning to recruit 29,000 people globally," the Chinese Academy of Sciences (CAS) wrote in a statement, adding the late-stage trials started in China's Hunan Province in November and will soon be rolled out in Indonesia, Pakistan, and Ecuador.

The vaccine did not cause serious adverse effects, other than mild side-effects including injection pain, redness and swelling, according to a paper published on Tuesday before it was peer reviewed.

The combined data from Phase 1 and 2 trials involved 950 healthy Chinese participants aged 18-59. Low dose and high dose versions were tested. The Phase 2 study also tested two doses versus three doses for both the low dose and high dose versions.

The higher dose given via three injections spaced 30 days apart did not induce an improved immune response compared to the lower dose, the paper said. The Phase 3 trial will look at the lower dose version given over three injections, it said.

Neutralizing antibodies against the virus were detected among at least 93 percent of participants who received three shots in different groups. The levels of vaccine-triggered antibodies were higher than those seen in samples of patients recovered from the disease, researchers said.

However, these antibody-based readings are on their own not sufficient to predict how effective ZF2001 will be in protecting people from the virus, researchers said, warning they could not yet determine the duration of immune responses.

The vaccine also triggered moderate cell-based immune responses, a crucial part of the human immune system that works differently from antibodies.
Production for CAS' COVID-19 vaccine has been put into operation in September, according to vaccine manufacturer Anhui Zhifei Longcom Biopharmaceutical Co. The annual output is expected to reach more than 300 million doses, the company said.

Latest data shows over 76,315 people have been infected with the coronavirus in Uzbekistan. Cases peaked between July and September and so far have not spiked again.

(With input from Reuters)
 
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China approves 1st application for Sinopharm vaccine rollout
By Xu Keyue, Hu Yuwei and Zhang Hongpei Source: Global Times Published: 2020/12/24 14:59:52

a520eac6-f6b8-4df2-978c-682d9b8da8e3.jpeg
Sinopharm's COVID-19 vaccine. Photo: VCG

China approved the country's leading vaccine producer Sinopharm's application for market rollout of its COVID-19 vaccines on Thursday, which marks China's first approval for a vaccine to combat the coronavirus.

The Center for Drug Evaluation of China's National Medical Products Administration has approved the application and started the examination procedure, a representative of Sinopharm told the Global Times.

Chinese experts predicted that conditional approval could be granted from January 1, 2021.

Shares of Sinopharm jumped 9 percent following the news. Shares linked to cold chain transport for vaccines also saw gains.

Sinopharm submitted its application on November 25. The company told the Global Times in a previous interview that it had collected data from countries carrying out clinical trials on its vaccine candidates, such as the United Arab Emirates. The results are expected to be good but it is up to Chinese health authorities to make the decision as the authorities have strict review standards.

It had reported phase III clinical data to China's State Food and Drug Administration and is in the process of giving more detailed data, as requested.

The vaccine maker will release its trial data in academic journals after approval, reports said.

Tao Lina, a Shanghai-based expert on vaccines and former Shanghai disease prevention and control employee, told the Global Times on Thursday that there could be a conditional market rollout of the COVID-19 vaccine around January 1, 2021 after the phase III clinical data is published.

Many areas in China including Zhuhai in South China's Guangdong Province, Yiwu, Jiaxing and Shaoxing in East China's Zhejiang Province, and Southwest China's Sichuan Province have authorized out emergency COVID-19 vaccine inoculation for high-risk groups to tackle imported infections and resurgence of sporadic local cases.

Meanwhile, some residents reached by the Global Times have expressed their concerns over the safety and efficacy of the vaccines. As China is basically safe thanks to the national anti-epidemic work, some said they would like to wait for the official approval before being vaccinated.

Some of those among the high-risk groups who had been vaccinated said they experienced no or not obvious adverse reactions after the shots.

Sinopharm's vaccines, which use inactivated virus unable to replicate in human cells to trigger an immune response, require two doses, clinical trial registration data showed.

The inactivated COVID-19 vaccine produced by Sinopharm was officially approved by UAE earlier this month. The vaccine has a proven efficacy of 86 percent, UAE health ministry said in early December, based on interim analysis of phase III clinical trials.
 
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Sinovac's COVID-19 vaccine shows 91.25% efficacy in Turkey trials
Source: Global Times Published: 2020/12/25 1:01:24

70b69fba-c74d-427b-93c4-ade6eec51452.jpeg
Sinovac's Covid-19 vaccine. Photo: VCG

Chinese vaccine producer Sinovac's inactivated COVID-19 vaccine CoronaVac shows 91.25 percent efficacy in Phase III clinical trials in Turkey, Turkish health ministry announced Thursday local time.

The data could be increasing, and with the evaluations of the Scientific Committee, "we were sure of the effect of the vaccine. We are now confident that the vaccine is effective and safe for Turkish people," Turkish Health Minister Fahrettin Koca said at a press conference on Thursday.

The result is an interim data, the Global Times learned from Sinovac.

Turkey hopefully will receive the first shipment of CoronaVac vaccines on Monday. Chinese authorities have completed approval process for the vaccine doses that will be sent to Turkey, according to Koca.

Earlier this month, Koca said the country had signed a contract to buy 50 million doses of the COVID-19 vaccine from Sinovac.

Turkey's decision to purchase Chinese COVID-19 vaccines reflects its trust in China, and China is ready to provide necessary assistance to Turkey, Chinese State Councilor and Foreign Minister Wang Yi told Turkish Foreign Minister Mevlut Cavusoglu on December 14 during a phone call.

Around 13,000 volunteers in Turkey participated in Sinovac's Phase III clinical trials, according to Reuters.

The first batch of 20 million doses of Sinovac vaccines is scheduled to be received in December and January. The second batch of 10 million doses will arrive in February.

All the 50 million doses are scheduled to arrive in Turkey by the end of February, according to the press conference.

"For efficacy analysis (i.e. whether the vaccine is effective to prevent COVID-19), we have to identify 40 volunteers developing COVID-19 [from all participants who have been taking doses]. Then, the independent safety board will look at the data and see whether these patients had vaccine or placebo, in order to calculate vaccine production rate," said the trials study coordinator Professor Murat Akova of the Infectious Diseases department at Hacettepe University in November, where the clinical tests were launched on September 17.

The local department requested the vaccine candidate to be at least 60 percent efficient as protocol set. The trials research team and its Ethics Committee can make the interim analysis when they found 20 COVID-19 patents among the volunteers, according to Akova.

Besides Sinovac's vaccine, Turkey also planned to receive 4.5 million doses of Pfizert/BioNTech vaccine by the end of March, among which 1-1.5 million will come in January, Koca said, noting that Turkey will sign a contract purchasing up to 30 million doses Thursday night or Friday.
 
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↑↑↑
Another Chinese adenovirus vector COVID-19 vaccine ready for human trials
Source: Xinhua| 2020-12-28 17:04:19|Editor: huaxia

139624188_16091462591401n.jpg
A medical worker prepares an injection with a dose of COVID-19 vaccine at the Spallanzani Hospital in Rome, Italy, Dec. 27, 2020. (Photo by Andrea Sabbadini/Xinhua)

BEIJING, Dec. 28 (Xinhua) -- One more Chinese adenovirus vector vaccine candidate against COVID-19 is ready for human trials at home and abroad, its developers said Monday.

Researchers from Tsinghua University, Tianjin Medical University and Kunming-based Walvax Biotechnology Co., Ltd. have started developing the vaccine since the outbreak of the epidemic. Compared with other candidates, it was produced using chimpanzee blood.

Because there is generally no pre-stored neutralizing antibody against chimpanzee adenovirus in the human body, the vaccine with this virus as the carrier will have the advantages of low adverse reactions, high production capacity and strong immunity after vaccination, said lead researcher Zhang Linqi, from Tsinghua University.

The vaccine makers have completed animal tests and started applying to launch human trials in China and overseas.

"No serious side effects have occurred in animals," said Zhang, adding that the results of the preclinical research support the safety of this vaccine and suggest the potential for further clinical tests.

Zhang noted that phase-3 clinical trials to verify the vaccine efficacy will be performed in pandemic areas abroad. "Like other Chinese COVID-19 vaccines, we are also facing the situation that there are not enough COVID-19 patients in China to participate in phase-3 trials."

An industrialization base of the patented chimpanzee adenovirus vector vaccine was launched Sunday in Beijing's Daxing District. Once the vaccine is proved effective after trials, it will be mass produced in the base.

The manufacturing plants are now under construction, and the vaccine is likely to hit market in mid-2021. The annual production capacity for the COVID-19 vaccine will top 200 million doses, according to a Walvax statement.

China currently has five vaccines entering phase-3 clinical trials including an adenovirus vector vaccine developed by the Academy of Military Sciences and CanSino Biologics Inc., said an official from the National Health Commission earlier in December.
 
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Chinese living overseas flock back home for COVID-19 vaccination, a vote of confidence in domestic vaccines
By Lin Xiaoyi, Lu Yameng, Hu Yuwei and Shan Jie Source: Global Times Published: 2020/12/28 19:37:37

As the COVID-19 pandemic rages across the world, vaccines have become a life-saving straw that many people are eager to grasp. But at the moment, the availability is limited and the first batches are earmarked for those in the most urgent need, such as medical staff and senior citizens.

In China, one of the leading countries in COVID-19 vaccine development, the government has been arranging vaccination for priority groups such as frontline health workers, inspection and quarantine officers at ports of entry, and personnel bound overseas for work.

However, a considerable number of Chinese living overseas have recently returned to China in order to get vaccinated.

The journey costs a lot of money and time but many believe it's worth it, people familiar with the situation told the Global Times.

The fact that some Chinese are flying back home for vaccination despite having alternative choices in the US or Europe also reflects the Chinese people's growing confidence in domestically produced vaccines, experts on vaccines told the Global Times.

China's five vaccine candidates are now undergoing their phase III clinical trials in more than 16 countries.

24a4cdf7-7c3e-446d-8e1c-f73987552ef9.jpeg
The vaccination center in Yiwu, East China's Zhejiang Photos: Yang Hui/GT

Expressions of confidence

"Sharing the experience of going back to China to get the coronavirus vaccine on social media accounts has become one of the most popular forms of bragging," Catherine Zhu (pseudonym), a naturalized Swiss citizen living in Zurich who is originally from China, told the Global Times.

Zhu spent nearly 70,000 yuan ($10,710) to get a one-way ticket back to China from Switzerland in late October, completing coronavirus nucleic acid and antibody tests with negative results within 48 hours before boarding, facing the possible risk of infection on the plane, and finally going through 14 days of quarantine. After getting the second dose of the COVID-19 vaccine made by China's Sinovac Biotech, Zhu said she thought all the tedious procedures of returning home were worthwhile.

"In Switzerland, the high number of new COVID-19 cases and the difficulty in availing the vaccine made me anxious all the time. Although we were reading in the media every day that the vaccine was coming, we were well aware of the fact that priority would be given to people over the age of 80," said Zhu.

"I decided to go back to China to get vaccinated at the first chance I had," she added, revealing her enthusiasm to return after seeing reports that COVID-19 vaccines produced by Chinese enterprises had passed biosafety inspection and proven to be effective, with minor side effects.

According to Zhu, there are currently many channels for overseas Chinese coming to China to make an appointment for vaccination, including booking appointments through local federations of returned overseas Chinese, community management departments and companies.

Zhu said she felt very lucky that she had no adverse reactions from the vaccine. In China, she was free to visit relatives and friends without any restrictions or pressures, and even went to the 3rd China International Import Expo (CIIE).

Zhu has returned to Switzerland where travelers from China are able to pass through customs quickly and return home without having to undergo quarantine and nucleic acid tests.

"For me, getting the vaccine is like wearing an armor. Although I will continue to wear a mask, wash my hands frequently and practice social distancing in the face of the severe epidemic situation in Europe, I know that there is a force from my motherland protecting me, which makes me feel extremely relieved," Zhu said.

fc51ee43-b5d0-4708-9cc3-27c3d77bc289.jpeg
People take COVID-19 vaccine in Hohhot, North China's Inner Mongolia on Monday. Photo: cnsphoto

Favorable policies

China has begun the vaccination for urgent use and will gradually open it to the public. For overseas Chinese, there have been favorable policies.

As early as in late October, several regions in East China's Zhejiang Province have provided preorder channels of COVID-19 vaccination for overseas Chinese, and some of them had already taken the injections.Qingtian county in East China's Zhejiang Province has a registered population of 570,000, but it is the hometown of more than 300,000 Chinese living overseas, including 100,000 in Italy.

Xu Xiaolin, head of the Qingtian clansman association in Italy, told the Global Times on Sunday that for overseas Chinese, vaccine is the solution for the pandemic, which has attracted Qingtian people living in Italy to take a round-trip to China for vaccination, especially those doing business. "As far as I know, several hundreds of Qingtian people in Italy have flown back for vaccination," said Xu.

The trip is not cheap. According to Xu, a one-way flight ticket is about $2,500, and the quarantine cost for a fortnight is at least $700. "The vaccines are not expensive though, only 400 yuan for two doses."

But the time consumed in the process is more notable. "For some people, it takes three or four months to complete the whole process," Xu said.

It is recommended that the first injection and the second injection be separated by 28 days. If you are in a rush to go abroad, the interval can be shortened to 14 days, an official responsible for overseas Chinese affairs at the Epidemic Prevention and Control Headquarters of Qingtian, told the Global Times.

e6862f21-4568-4d8c-9bec-3791277aab25.jpeg
GT

Those who have returned from overseas can make an appointment for vaccines at the earliest after 14 days of medical observation at the port of entry and seven days of health observation at home, along with a negative nucleic acid test result, he said.

Xu's association has been helping Qingtian people in Italy to understand the favorable policies of Zhejiang. "We are also communicating the needs of Chinese people in Italy to the Chinese government," he said.At present, the emergency vaccination program in Qingtian county is mainly aimed at people from Qingtian who need to go abroad urgently and are aged between 18 and 59, the Qingtian Overseas Chinese Federation said in a response to a netizen asking whether the inoculation can be done before going abroad in March 2021 on the local government website.

"The COVID-19 vaccine inoculation is open to all the people who were born in Qingtian or whose native place of (ancestral) origin lies in Qingtian. They can choose to register for COVID-19 vaccination voluntarily," according to the official.

Eligible residents should carry their passport or ID card and register at the Comprehensive Service Station of the Epidemic Prevention and Control Headquarters of Qingtian county. After registration, the government will purchase vaccines, and when the vaccines arrive, the registered residents can get the injection after being notified of the place and time, according to the official.

"Registration was opened in late September. The first batch of people got vaccinated on October 9 at nine vaccination sites in Qingtian county. More than 4,000 people have been vaccinated until now."

"The main purpose of inoculation is to protect Chinese people who plan to go overseas," said the official.

92956ad9-05d1-4a26-b45d-3c3f263d4be0.jpeg
The vaccination center in Yiwu, East China's Zhejiang Photos: Yang Hui/GT

Growing confidence

In past decades, many Chinese people preferred to use vaccines produced by Western pharmaceutical giants if they had a choice. However, observers suggested that the COVID-19 vaccine has witnessed a change in preference among many Chinese people partly due to the improvement of vaccine technology and regulation in China, which has boosted such confidence.

"We Chinese in Italy recognize the COVID-19 vaccines developed by China very well and have confidence in its safety and effectiveness. China's vaccines are good news to the world," Xu said.

China's vaccine makers have been at a low ebb in recent years after a number of scandals including Changsheng Bio-technology Co's fabrication of data and sales of substandard vaccines for babies in 2018, which wrecked public trust and infuriated parents. Now things appear to be changing as a number of promising COVID-19 vaccines have helped the sector regain public confidence.

Representatives of both Sinopharm and Sinovac have previously told the Global Times that China's drug regulators review their phase III clinical trial data following a rigorous standard that is even stricter than many Western countries.

The previous vaccine crisis indeed dented Chinese people's faith in the state-owned immunological products and glorified foreign biological products as well as Western regulators, experts said. However, China's vaccine industry that was scarred by quality risks and scandals is now properly regulated, whereas Western countries' fragile response to the pandemic has smashed many Chinese people's trust in Western solutions, they said.
 
.
Chinese living overseas flock back home for COVID-19 vaccination, a vote of confidence in domestic vaccines
By Lin Xiaoyi, Lu Yameng, Hu Yuwei and Shan Jie Source: Global Times Published: 2020/12/28 19:37:37

As the COVID-19 pandemic rages across the world, vaccines have become a life-saving straw that many people are eager to grasp. But at the moment, the availability is limited and the first batches are earmarked for those in the most urgent need, such as medical staff and senior citizens.

In China, one of the leading countries in COVID-19 vaccine development, the government has been arranging vaccination for priority groups such as frontline health workers, inspection and quarantine officers at ports of entry, and personnel bound overseas for work.

However, a considerable number of Chinese living overseas have recently returned to China in order to get vaccinated.

The journey costs a lot of money and time but many believe it's worth it, people familiar with the situation told the Global Times.

The fact that some Chinese are flying back home for vaccination despite having alternative choices in the US or Europe also reflects the Chinese people's growing confidence in domestically produced vaccines, experts on vaccines told the Global Times.

China's five vaccine candidates are now undergoing their phase III clinical trials in more than 16 countries.

24a4cdf7-7c3e-446d-8e1c-f73987552ef9.jpeg
The vaccination center in Yiwu, East China's Zhejiang Photos: Yang Hui/GT

Expressions of confidence

"Sharing the experience of going back to China to get the coronavirus vaccine on social media accounts has become one of the most popular forms of bragging," Catherine Zhu (pseudonym), a naturalized Swiss citizen living in Zurich who is originally from China, told the Global Times.

Zhu spent nearly 70,000 yuan ($10,710) to get a one-way ticket back to China from Switzerland in late October, completing coronavirus nucleic acid and antibody tests with negative results within 48 hours before boarding, facing the possible risk of infection on the plane, and finally going through 14 days of quarantine. After getting the second dose of the COVID-19 vaccine made by China's Sinovac Biotech, Zhu said she thought all the tedious procedures of returning home were worthwhile.

"In Switzerland, the high number of new COVID-19 cases and the difficulty in availing the vaccine made me anxious all the time. Although we were reading in the media every day that the vaccine was coming, we were well aware of the fact that priority would be given to people over the age of 80," said Zhu.

"I decided to go back to China to get vaccinated at the first chance I had," she added, revealing her enthusiasm to return after seeing reports that COVID-19 vaccines produced by Chinese enterprises had passed biosafety inspection and proven to be effective, with minor side effects.

According to Zhu, there are currently many channels for overseas Chinese coming to China to make an appointment for vaccination, including booking appointments through local federations of returned overseas Chinese, community management departments and companies.

Zhu said she felt very lucky that she had no adverse reactions from the vaccine. In China, she was free to visit relatives and friends without any restrictions or pressures, and even went to the 3rd China International Import Expo (CIIE).

Zhu has returned to Switzerland where travelers from China are able to pass through customs quickly and return home without having to undergo quarantine and nucleic acid tests.

"For me, getting the vaccine is like wearing an armor. Although I will continue to wear a mask, wash my hands frequently and practice social distancing in the face of the severe epidemic situation in Europe, I know that there is a force from my motherland protecting me, which makes me feel extremely relieved," Zhu said.

fc51ee43-b5d0-4708-9cc3-27c3d77bc289.jpeg
People take COVID-19 vaccine in Hohhot, North China's Inner Mongolia on Monday. Photo: cnsphoto

Favorable policies

China has begun the vaccination for urgent use and will gradually open it to the public. For overseas Chinese, there have been favorable policies.

As early as in late October, several regions in East China's Zhejiang Province have provided preorder channels of COVID-19 vaccination for overseas Chinese, and some of them had already taken the injections.Qingtian county in East China's Zhejiang Province has a registered population of 570,000, but it is the hometown of more than 300,000 Chinese living overseas, including 100,000 in Italy.

Xu Xiaolin, head of the Qingtian clansman association in Italy, told the Global Times on Sunday that for overseas Chinese, vaccine is the solution for the pandemic, which has attracted Qingtian people living in Italy to take a round-trip to China for vaccination, especially those doing business. "As far as I know, several hundreds of Qingtian people in Italy have flown back for vaccination," said Xu.

The trip is not cheap. According to Xu, a one-way flight ticket is about $2,500, and the quarantine cost for a fortnight is at least $700. "The vaccines are not expensive though, only 400 yuan for two doses."

But the time consumed in the process is more notable. "For some people, it takes three or four months to complete the whole process," Xu said.

It is recommended that the first injection and the second injection be separated by 28 days. If you are in a rush to go abroad, the interval can be shortened to 14 days, an official responsible for overseas Chinese affairs at the Epidemic Prevention and Control Headquarters of Qingtian, told the Global Times.

e6862f21-4568-4d8c-9bec-3791277aab25.jpeg
GT

Those who have returned from overseas can make an appointment for vaccines at the earliest after 14 days of medical observation at the port of entry and seven days of health observation at home, along with a negative nucleic acid test result, he said.

Xu's association has been helping Qingtian people in Italy to understand the favorable policies of Zhejiang. "We are also communicating the needs of Chinese people in Italy to the Chinese government," he said.At present, the emergency vaccination program in Qingtian county is mainly aimed at people from Qingtian who need to go abroad urgently and are aged between 18 and 59, the Qingtian Overseas Chinese Federation said in a response to a netizen asking whether the inoculation can be done before going abroad in March 2021 on the local government website.

"The COVID-19 vaccine inoculation is open to all the people who were born in Qingtian or whose native place of (ancestral) origin lies in Qingtian. They can choose to register for COVID-19 vaccination voluntarily," according to the official.

Eligible residents should carry their passport or ID card and register at the Comprehensive Service Station of the Epidemic Prevention and Control Headquarters of Qingtian county. After registration, the government will purchase vaccines, and when the vaccines arrive, the registered residents can get the injection after being notified of the place and time, according to the official.

"Registration was opened in late September. The first batch of people got vaccinated on October 9 at nine vaccination sites in Qingtian county. More than 4,000 people have been vaccinated until now."

"The main purpose of inoculation is to protect Chinese people who plan to go overseas," said the official.

92956ad9-05d1-4a26-b45d-3c3f263d4be0.jpeg
The vaccination center in Yiwu, East China's Zhejiang Photos: Yang Hui/GT

Growing confidence

In past decades, many Chinese people preferred to use vaccines produced by Western pharmaceutical giants if they had a choice. However, observers suggested that the COVID-19 vaccine has witnessed a change in preference among many Chinese people partly due to the improvement of vaccine technology and regulation in China, which has boosted such confidence.

"We Chinese in Italy recognize the COVID-19 vaccines developed by China very well and have confidence in its safety and effectiveness. China's vaccines are good news to the world," Xu said.

China's vaccine makers have been at a low ebb in recent years after a number of scandals including Changsheng Bio-technology Co's fabrication of data and sales of substandard vaccines for babies in 2018, which wrecked public trust and infuriated parents. Now things appear to be changing as a number of promising COVID-19 vaccines have helped the sector regain public confidence.

Representatives of both Sinopharm and Sinovac have previously told the Global Times that China's drug regulators review their phase III clinical trial data following a rigorous standard that is even stricter than many Western countries.

The previous vaccine crisis indeed dented Chinese people's faith in the state-owned immunological products and glorified foreign biological products as well as Western regulators, experts said. However, China's vaccine industry that was scarred by quality risks and scandals is now properly regulated, whereas Western countries' fragile response to the pandemic has smashed many Chinese people's trust in Western solutions, they said.

I wonder what is the policy regarding Taiwan residents... especially if you are holding 台胞证。I am thinking of this option.
 
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But the million dollar question is whether Chinese vaccine will be reliable ?
Just a year and half old report.
Vaccines produced in chinese labs for approval cannot be compared to mass produced vaccines as we see in this report.
 
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China’s Sinovac to Boost Covid-19 Vaccine Production at Beijing Plant by Billion Doses
TANG SHIHUA
DATE: 22 MINUTES AGO / SOURCE: YICAI

China’s Sinovac to Boost Covid-19 Vaccine Production at Beijing Plant by Billion Doses
China’s Sinovac to Boost Covid-19 Vaccine Production at Beijing Plant by Billion Doses

(Yicai Global) Dec. 30 -- China’s Sinovac Life Sciences will expand output at its Covid-19 vaccine production base at the Beijing Daxing Biomedical Industrial Park by an additional one billion doses a year, the Beijing Daily reported today.

The unit of Beijing-based pharma giant Sinovac Biotech currently has an annual production capacity of 300 million doses, it said. No details about investment amounts or completion dates were given.

Sinovac Life is likely putting to good use the USD515 million cash injection that it received from Sino Pharmaceutical, one of the country’s biggest generic drugmakers, earlier this month to develop its inactivated vaccine.

The Daxing Biological Park has already lured investment from over 4,000 biopharmaceutical firms. Earlier this week, Walvax Biotechnology announced that it will build a Covid-19 vaccine plant at the industrial park with an annual output of 150 million doses a year. The Kunming, southwestern Yunnan province-based drugmaker is developing a chimpanzee adenovirus-vectored jab that has been demonstrated to confer immunity to rhesus monkeys but has yet to be tested on humans.

Sinovac Life’s CoronaVac, which uses a killed rather than an attenuated form of the novel coronavirus, is at the final stage of Phase III clinical trials. It was declared safe and effective by Brazilian researchers last week, but the company has yet to make public the results of its trials.
 
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