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The electric plants powering China’s new agricultural revolution
Scientists hail breakthrough as results of the world’s largest experiment confirm fruit and vegetable output can soar without chemical pesticides and fertilisers

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Lettuce growing in an electro culture chamber developed as part of China’s giant experiment to find out if electricity can boost plant growth. Photo: Liu Binjiang


Stephen Chen


PUBLISHED : Sunday, 16 September, 2018, 1:00am
UPDATED : Sunday, 16 September, 2018, 1:00am​

Chinese growers have the answer to a question that has been baffling scientists for three centuries: Can electricity boost plant growth?

To find out, China has been conducting the world’s largest experiment and the results are transforming agricultural production in the world’s most populous nation with a jolt.

Across the country, from Xinjiang’s remote Gobi Desert to the developed coastal areas facing the Pacific Ocean, vegetable greenhouse farms with a combined area of more than 3,600 hectares (8,895 acres) have been taking part in an “electro culture” programme funded by the Chinese government.


Last month the Chinese Academy of Agricultural Sciences and other government research institutes released the findings of nearly three decades of study in areas with different climate, soil conditions and plantation habits. They are hailing the results as a breakthrough.

The technique has boosted vegetable output by 20 to 30 per cent. Pesticide use has decreased 70 to 100 per cent. And fertiliser consumption has dropped more than 20 per cent.

The vegetables grow under bare copper wires, set about three metres (10 feet) above ground level and stretching end to end under the greenhouse roof. The wires are capable of generating rapid, positive charges as high as 50,000 volts, or more than 400 times the standard residential voltage in the US.


The high frequency electricity kills bacteria and virus-transmitting diseases in the air or soil. It also suppresses the surface tension of water on leaves, accelerating vaporisation.

Within the plants, the transport of naturally charged particles, such as bicarbonate and calcium ions, speed up and metabolic activities, like carbon dioxide absorption and photosynthesis, also increase.

Professor Liu Binjiang, government agriculture scientist and a leading member of the project, said the electric current flowing through the wires is only a few millionths of an ampere by volume – lower than a smartphone cable’s workload.

“It does absolutely no harm to the plants or to humans standing nearby,” he said.

Thanks to the positive findings of the study, the area devoted to electrified farms in China is now growing with unprecedented speed, according to Liu, from 1,000 to 1,300 hectares each year.

That means up to 40 per cent growth in electro culture farming could be achieved within the next 12 months.

“Most recent investments have come from the private sector,” Liu said. “The business is taking off. We are supplying the technology and equipment to other countries including the Netherlands, United States, Australia and Malaysia.

“China is a step ahead of the world.”


THE HISTORY


It was not always so. In fact, China was more than 200 years late to the game.

In 1746, just a few years before Benjamin Franklin sent a kite to catch lightning in a storm, Dr Maimbray of Edinburgh in Scotland electrified two myrtles.

He observed the trees put forth new branches in October, something which had never happened before.

The news travelled. Many similar studies were carried out across Europe, some confirming Maimbray’s findings, others not.

One experiment in Turin, Italy, for instance, found the plants became unfruitful and wilted after an unusually prolific period.

In 1902, physics professor S. Lemstroem visited the Arctic region and discovered some trees grew faster under the aurora borealis than those in milder climates further south.

Lemstroem attributed the phenomenon to the natural electrical conditions produced by the aurora, also known as the northern lights. He conducted a series of experiments in the laboratory to prove it and even wrote a book to promote his hypothesis.

British physicist Sir Oliver Lodge, a key inventor in the development of radio, read the book and reportedly achieved a 24 to 39 per cent increase in wheat grain yield in an eight-hectare experiment.

It caught the attention of governments. The British and American authorities each commissioned separate studies on electro culture in the early 20th century.

The British findings were positive, while the American results were negative.


These experiments were mostly small and conducted in open fields, with conditions which varied from one location to another. The wide range of natural elements affected the final output and there was no universal standard for hardware design or technical details such as voltage and frequency.

The scientists in these pioneering studies also lacked advanced equipment, such as today’s portable spectrum analyser, to study the plant’s response to electricity at the molecular level.

As a consequence, explanations of the observed phenomenon remained speculative and interest waned with the advent of chemical fertilisers and pesticides to achieve mass agricultural production.

CHINA TAKES THE LEAD

Public interest in electro culture revived with the rise of organic farming and the Chinese government started funding experiments in the technique in 1990.

He Feng, senior technician of Yufa Jingnan Vegetable Production and Sales, one of Beijing’s largest vegetable producers, said the company had taken part in the programme since 2014 and the results were “very satisfactory”.

In just two years the electrified vegetables had brought in extra revenue of nearly 1.2 million yuan (US$175,000).

“We are still running the equipment, which consumes very little power,” he said.


One hectare of electrified greenhouse requires about 15 kilowatt-hours of electricity per day, which is about half the power usage of an average American family.

Inside the greenhouse the air smells like the aftermath of a summer thunderstorm. Humidity is low and the plants rarely get sick.

The biggest burden is the installation cost, He said, with the necessary hardware costing tens of thousands of yuan. Without government support, the company could not have afforded to wire up all its greenhouses.

Liu Yongyi, owner of City Luhai Xinghua Sightseeing Agriculture company in Beijing’s Daxing district, which is also engaging in electro culture, said the technology would significantly improve China’s food safety by massively reducing the use of pesticides.

“Pesticide residue is a huge threat to public health. Electricity provides a physical solution to disease and pest control. It is much cleaner than chemicals. The government should subsidise the electro culture revolution,” he said.

Liu said visitors to the farm were intrigued when they saw the system at work and he believed the public would be quick to embrace the technology.

“The theory is easy to understand. I believe people would be willing to pay a premium for electrified vegetables and fruits in the near future,” he said.

Professor Guo Yalong, a researcher at the Chinese Academy of Beijing’s Institute of Botany, said the impact of electricity on plant “definitely exists”.

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“Electricity is like air and water. It is part of the natural environment,” said Guo, who was not involved in the project.

“Many ionised particles in plants have either negative or positive charges. They can respond to the presence of a man-made electric field nearby,” he said.

China has greenhouses covering more than 4 million hectares, producing nearly 1 trillion yuan worth of vegetables each year.

Professor Liu said there were no plans to electrify them all, as the investment would be unaffordable for most farmers.

His project team is taking a different approach and developing a compact, all-in-one vegetable growing chamber using electro culture technology.

“Each family would be able to grow their own food in the kitchen, on the balcony or in the backyard,” he said.

The chamber uses an artificial light source and electric field to stimulate plant growth and prevent diseases. Operation is automatic and almost care and maintenance free.

“One day these tiny chambers may become an alternative to large scale farms,” Liu said. “That would trigger another agricultural revolution.”


The electric plants powering China’s new agricultural revolution | South China Morning Post
 
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Earthquake Detected with Fiber Optic Gyroscope at NTSC---Chinese Academy of Sciences
Sep 17, 2018

An M 5.3 earthquake occurred at 19:06:34 on September 12, 2018 in Ningqiang, Hanzhong city, Shaanxi province, China. It was successfully recorded by the fiber optic gyroscope (FOG) at National Time Service Center (NTSC) of the Chinese Academy of Sciences with ~85 seconds delay after the initial earthquake.

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Fig.1 The detected seismic signal by FOG. (Image by NTSC)

The FOG is collaboratively developed by NTSC and Peking University with aim to measure the Universal Time (UT1) with high precision for the applications of national time service, space science & technology, geophysics, etc.

The FOG based on Sngnac effect is used to measure the spin rate with high precision and real-time performance. It is well known for low maintenance requirements, small environment sensitivity, high reliability and long lifetime, mostly due to its all solid structure and no moving part, thus it provides a unique method to implement the UT1 measurement systems.

As required by the high precision measurement, the FOG is put in a laboratory 30 meters below the ground, where the stable temperature & humidity conditions, as well as low level vibration provide an ideal base for the gyroscope.

The detected seismic signal shows the rotation component (1D) of this earthquake, which is an important information for the seismology and earthquake forecasting. With further improvement and upgrade, giant-FOG will become a powerful tool for UT1 measurement, geophysics, general relativity, etc.
 
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Researchers create 'breathable' battery
CGTN
2018-09-17 15:00 GMT+8

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Chinese researchers have made breakthroughs by using composite materials with sodium carbonate to produce a rechargeable battery that pulls carbon dioxide from the air for its discharge.

A team led by Chen Jun, a professor from Nankai University's College of Chemistry in Tianjin, has assembled the battery with a 350 mAh capacity and 183 Wh/kg energy density, Science and Technology Daily reported.

It obtains oxygen from the air when discharging and releases oxygen into the air when charging, and is called a "breathable" battery.

Too much sodium will create dendrites at the negative pole, causing a short circuit, and the production of sodium will need huge energy consumption in the electrolysis of sodium chloride or sodium hydroxide.

Chinese researchers produced the composite material of sodium carbonate on multiple-walled carbon nanotubes, and by controlling the capacity of the battery, they effectively prohibited the formation of dendrites.

The sodium-carbon dioxide battery comes after the breathable lithium-air battery that uses oxygen for its discharge. In comparison, the sodium-carbon dioxide battery is much greener, and sodium carbonate is easy to produce.

The battery will provide an energy supply for the Mars probe, since the planet's air is 95 percent carbon dioxide.
 
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NATURE INDEX | 19 SEPTEMBER 2018
Movers and shakers
Although China leads the pack, fast-moving institutions are building their research reputations the world over.

d41586-018-06625-5_16112998.jpg
Excavations led by Griffith University at Leang Bulu Bettue, a cave on Sulawesi island, Indonesia.Credit: Justin Mott/Mott Visuals

These 16 institutions were selected from among the most improved institutions in the Nature Index between 2015 and 2017. Some showed exceptional absolute and relative growth in their overall contribution to the papers in the journals tracked by the index, measured by fractional count (FC), whereas others excelled in a specific subject category. Chinese institutions make up more than half of the top 100 rising stars, far exceeding the 20 from the United States, and 4 each from Germany and the Netherlands.


---> Movers and shakers | Nature Index 2018 Rising Stars


++++++++++++++######++++++++++++++


NATURE INDEX | 19 SEPTEMBER 2018
Challenger states
Strength in different sectors, subjects and regions contributes to a country's success.

These six countries have experienced the highest absolute and percentage increases in their contribution to the Nature Index since 2015. While China is making waves among the traditional scientific powers, the other five nations are disrupting lower-tiered research strongholds.

d41586-018-06623-7_16112870.png
Source: UNESCO/OECD

---> Challenger states | Nature Index 2018 Rising Stars
 
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E-skin able to detect changes in wind, water drops and moving ants
September 20, 2018 by Bob Yirka, Tech Xplore

Sensory skins mounted on the fingers of a mechanical arm. Credit: Wu et al., Sci. Robot. 3, eaat0429 (2018)

A team of researchers working at the Chinese Academy of Sciences has developed an electronic skin that is sensitive enough to detect changes in air moving, falling drops and moving ants. In their paper published in the journal Science Robotics, the group describes their e-skin and possible applications.

As scientists continue to improve the look and capabilities of robots, one of the prime areas of research is skin. Robotics engineers would like to develop an e-skin that is similar to human skin. This is because it is believed that future robots will need the ability to "feel" things in order to perform sophisticated, yet subtle activities. Such activities might include responding to temperature, noticing changes in texture, or processing pleasurable sensations. In this new effort, the researchers in China have made advances in sensitivity of an electronic skin.

The new skin is able to detect very small changes in pressure and convert what it finds to pulses. It was made by covering a magnetic sensor with a hollow polymer membrane and then embedding magnetic beads in the top part of the membrane. As pressure is applied, the membrane is pushed in, which allows the embedded magnetic beads to move closer to the sensor. The resistance created is sent to an electronic circuit. The electronic circuit then converts the signals to a series of pulses of varying frequencies that reflect the amount of pressure being "felt" on the skin.

E-skins that can “pulse” in response to pressure. Credit: Wu et al., Sci. Robot. 3, eaat0429 (2018)

The researchers created an artificial finger covered with the e-skin and then attached the finger to an artificial arm for testing purposes. They report that the skin they created was able to generate pulses for pressure as small as that created by a line of ants running over the surface. It was also able to detect changes in wind speed and differences in the size of water drops that impacted on its surface.

The researchers report that their e-skin was able to detect pressure changes better than human skin, in some cases. They believe their new e-skin could prove useful in robotics and as a means to improve the performance of artificial limbs.

More information: A skin-inspired tactile sensor for smart prosthetics, Science Robotics 19 Sep 2018: Vol. 3, Issue 22, eaat0429, DOI: 10.1126/scirobotics.aat0429, http://robotics.sciencemag.org/content/3/22/eaat0429


https://techxplore.com/news/2018-09-e-skin-ants.html
 
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Safest random numbers generated

2018-09-21 09:37:30 Global Times Editor : Li Yan

Researchers eye broad applications

A recent study by Chinese scientists for the first time revealed the safest random numbers in the world, which cannot be detected or hacked even by the most advanced computers and has a broad application in areas such as cryptography.

The results of the study were published on Nature, the international journal of science, on Thursday.

The project was jointly conducted by a team of top Chinese quantum physicist Pan Jianwei from the University of Science and Technology of China (USTC), Shanghai Institute of Microsystems and Information Technology of the Chinese Academy of Sciences and Japan's NTT Basic Research Laboratories and NTT Research Center for Theoretical Quantum Physics, according to a press release the USTC sent to the Global Times on Thursday.

The study is about device-independent quantum random number generation, which produces unpredictable genuine randomness without assumptions on the inner workings of devices, and is the ultimate goal in the field of quantum information science, according to project information published on Nature.

"The generator of device-independent quantum random numbers is the safest production device for random numbers, and the random numbers it generates cannot be detected even by the world's most powerful quantum computer eavesdroppers have," the press release said.

Many countries are also researching such generators and the US' National Institute of Standards and Technology is attempting to use such a generator to establish a national standard on random numbers, according to the press release.

"There will be a random number leakage if we accidentally used the quantum random number generator produced by a malicious third party, and our new achievement ensures that even using the malicious third party provided generator, it could still produce genuine random numbers which could not be leaked," Pan was quoted by the People's Daily as saying on Thursday.

The random numbers have significant applications in both science and daily life in weather forecasting, research and development on medication and nuclear weapons and design of new materials, the press release said.

The random numbers could control the evolution of the system needed in artificial intelligence, and is also the safe foundation for communication security and modern cryptography.

Scientists from USTC will establish stable and high-speed device-independent quantum random number generators, and provide safe random numbers, and even help form a new international standard for random numbers, the People's Daily reported Thursday.

Pan's team has engaged in leading research in quantum science and technology.

In June, Pan's team set a world record for entanglement of 18 quantum bits, keeping their lead in the field of quantum computing.

http://www.ecns.cn/news/sci-tech/2018-09-21/detail-ifyyehna1448824.shtml
 
.
NATURE INDEX | 19 SEPTEMBER 2018
Movers and shakers
Although China leads the pack, fast-moving institutions are building their research reputations the world over.

d41586-018-06625-5_16112998.jpg
Excavations led by Griffith University at Leang Bulu Bettue, a cave on Sulawesi island, Indonesia.Credit: Justin Mott/Mott Visuals

These 16 institutions were selected from among the most improved institutions in the Nature Index between 2015 and 2017. Some showed exceptional absolute and relative growth in their overall contribution to the papers in the journals tracked by the index, measured by fractional count (FC), whereas others excelled in a specific subject category. Chinese institutions make up more than half of the top 100 rising stars, far exceeding the 20 from the United States, and 4 each from Germany and the Netherlands.


---> Movers and shakers | Nature Index 2018 Rising Stars


++++++++++++++######++++++++++++++


NATURE INDEX | 19 SEPTEMBER 2018
Challenger states
Strength in different sectors, subjects and regions contributes to a country's success.

These six countries have experienced the highest absolute and percentage increases in their contribution to the Nature Index since 2015. While China is making waves among the traditional scientific powers, the other five nations are disrupting lower-tiered research strongholds.

d41586-018-06623-7_16112870.png
Source: UNESCO/OECD

---> Challenger states | Nature Index 2018 Rising Stars

Wow we have over 1.6 mln researchers!

Also in the chart below, we have produced a FC of more than 9000 (2017) and that stood at less than half of the usa did.
Still a long way to go, but keep it up China :china::china::china:



d41586-018-06623-7_16112872.png


Safest random numbers generated

2018-09-21 09:37:30 Global Times Editor : Li Yan

Researchers eye broad applications

A recent study by Chinese scientists for the first time revealed the safest random numbers in the world, which cannot be detected or hacked even by the most advanced computers and has a broad application in areas such as cryptography.

The results of the study were published on Nature, the international journal of science, on Thursday.

The project was jointly conducted by a team of top Chinese quantum physicist Pan Jianwei from the University of Science and Technology of China (USTC), Shanghai Institute of Microsystems and Information Technology of the Chinese Academy of Sciences and Japan's NTT Basic Research Laboratories and NTT Research Center for Theoretical Quantum Physics, according to a press release the USTC sent to the Global Times on Thursday.

The study is about device-independent quantum random number generation, which produces unpredictable genuine randomness without assumptions on the inner workings of devices, and is the ultimate goal in the field of quantum information science, according to project information published on Nature.

"The generator of device-independent quantum random numbers is the safest production device for random numbers, and the random numbers it generates cannot be detected even by the world's most powerful quantum computer eavesdroppers have," the press release said.

Many countries are also researching such generators and the US' National Institute of Standards and Technology is attempting to use such a generator to establish a national standard on random numbers, according to the press release.

"There will be a random number leakage if we accidentally used the quantum random number generator produced by a malicious third party, and our new achievement ensures that even using the malicious third party provided generator, it could still produce genuine random numbers which could not be leaked," Pan was quoted by the People's Daily as saying on Thursday.

The random numbers have significant applications in both science and daily life in weather forecasting, research and development on medication and nuclear weapons and design of new materials, the press release said.

The random numbers could control the evolution of the system needed in artificial intelligence, and is also the safe foundation for communication security and modern cryptography.

Scientists from USTC will establish stable and high-speed device-independent quantum random number generators, and provide safe random numbers, and even help form a new international standard for random numbers, the People's Daily reported Thursday.

Pan's team has engaged in leading research in quantum science and technology.

In June, Pan's team set a world record for entanglement of 18 quantum bits, keeping their lead in the field of quantum computing.

http://www.ecns.cn/news/sci-tech/2018-09-21/detail-ifyyehna1448824.shtml


Congrats! :china::victory:
 
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New study finds Zika vaccine can treat brain tumors
CGTN
2018-09-23 22:53 GMT+8


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Researchers from China and the US say a Zika virus vaccine they developed can inhibit brain tumor growth.

ScienceNet.cn reported the new study which had been published earlier by mBio, a journal of the American Society for Microbiology.

According to the report, the joint study was led by Qin Chengfeng from the Academy of Military Medical Sciences in China, Man Jianghong from the National Center of Biomedical Analysis in China and Shi Peiyong from the University of Texas.

Glioblastoma (GBM) is the most common and malignant form of primary brain tumor. Treatment with surgery, radiation and chemotherapy has limited effect, and the recurrence rate is almost 100 percent. The average survival time of patients is about 14 months.

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Scientists said they have developed a Zika virus vaccine that can inhibit brain tumor growth. /VCG Photo

Previous studies found that the GBM stem cells played a key role in the development and recurrence of the fatal brain disease.

In 2017, researchers from the Academy of Military Medical Sciences in China and the University of Texas discovered that the Zika virus could infect and kill neural precursor cells and neural stem cells. And then, they developed a genetically modified live attenuated Zika virus vaccine (ZIKV-LAV).

They hypothesized that the Zika virus could also kill GBM stem cells, which have similar properties to neural stem cells.

Researchers injected the ZIKV-LAV into mice and it did not cause any abnormal behaviors or damage to the brain and other organs, indicating that the vaccine was safe.

Then, they found that the tumor sizes were significantly reduced, and GBM stem cells were infected and killed in the brains of mice. Healthy cells were not harmed.

After further gene analysis, researchers found the mechanism of how the Zika virus works: The virus infection triggered a strong antiviral response, which elicited inflammation that killed GBM stem cells.

In experiments, the Zika virus also prolonged the survival time of mice.

The Zika virus is spread mostly through the bite of an infected Aedes mosquito. It can be passed on by a pregnant woman to her baby.

According to researchers, the study offers a new treatment for brain tumors, and they plan to work with clinicians to test the efficacy and safety of the vaccine in patients.

(Top image: Zika is mostly spread by the bite of an infected mosquito. /VCG Photo )
 
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Quantum radar tech to counter stealth
By ZHAO LEI | China Daily | Updated: 2018-09-25 07:13
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A J-20 fighter joins a drill in this undated photo. [Yang Jun / Xinhua]
A major State-owned defense contractor has designed and built a cutting-edge quantum radar, which military observers say will eventually be able to detect stealth aircraft from great distances.​

The radar, developed and made by the Nanjing Research Institute of Electronics Technology in Jiangsu province, is able to detect and track targets more than 100 kilometers away, Sun Jun, head of the institute's Intelligent Detection Technology Laboratory, told China Daily in an exclusive interview.

The institute has been working with the University of Science and Technology of China and Nanjing University along with other research partners in carrying out field tests of the radar's prototype, and has extensively improved its accuracy and sensitivity, he said.

The radar is still undergoing tests and is more like a prototype demonstration of future capabilities, Sun said, adding that future versions will have better anti-stealth properties.

"The characteristics of quantum radar include high reliability, accuracy and viability in sophisticated electromagnetic environments. It also has good mobility that will allow it to be mounted on multiple kinds of carriers," the senior engineer said. "It has resolved traditional radar difficulties in terms of handling stealth targets and surviving enemy countermeasures."

The Nanjing institute, part of Beijing-based China Electronics Technology Group Corp, is the country's largest and most developed designer of military surveillance radar systems. Its products have a wide presence in the People's Liberation Army and have been sold to more than 20 nations in Africa and Asia, according to the institute.

Traditional military radar relies on radio waves to detect targets, which consequently make them susceptible to jamming measures. Most existing radar systems cannot detect stealth aircraft because such planes are made of radar-absorbent materials and have "stealthy" aerodynamic designs.

By comparison, quantum radars transmit subatomic particles, instead of radio waves, when they search for targets, so they will not be affected by radar-absorbent materials and low-signature designs. Moreover, quantum radars are not fooled by traditional radar-jamming tactics.

In addition to these advantages, quantum radars can also be adopted in missile defense and space exploration in the future. They will revolutionize radar arsenals, according to researchers from PLA National University of Defense Technology in Changsha, Hunan province.

China has been allotting a considerable amount of resources to quantum technologies in an attempt to lead what Chinese leaders consider one of the most important fields in tomorrow's science and technology realm.
 
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Multicenter Study Finds IVUS-Guided Drug-Eluting Stent Implantation Improves Clinical Outcomes in All-Comer Patients

Results from the ULTIMATE Trial Reported at TCT 2018 and Published Simultaneously in JACC

SAN DIEGO – September 24, 2018 – The first study designed to determine the benefits of intravascular ultrasound (IVUS) guidance over angiography guidance during drug-eluting stent (DES) implantation in all-comer patients found that IVUS improved clinical outcomes by lowering the rate of target vessel failure at one year.

Findings from the ULTIMATE trial were reported today at the 30th annual Transcatheter Cardiovascular Therapeutics (TCT) scientific symposium. Sponsored by the Cardiovascular Research Foundation (CRF), TCT is the world’s premier educational meeting specializing in interventional cardiovascular medicine. The study was also published simultaneously in the Journal of the American College of Cardiology (JACC).

IVUS is an intravascular imaging modality that provides detailed anatomic information about reference vessel dimensions and lesion characteristics, including severity of diameter stenosis, lesion length, and morphology (vulnerable plaque), which is less well-detected by coronary angiography. Whether the routine use of IVUS is associated with improved outcomes in all-comer patients is not known.

From August 2014 to May 2017, a total of 1,448 all-comer patients from eight centers in China who were undergoing DES implantation were randomly assigned (1:1) to either IVUS guidance (n=724) or angiography guidance (n=724). Multi-vessel disease was seen in 54.9% of patients. Mean lesion length was 34.5 mm, and 66.9% of lesions were classified as Type B2/C lesions. IVUS-guided procedures were longer in duration, and on a per-lesion basis used slightly greater stent diameters and stent lengths.

The primary endpoint was target vessel failure (TVF) at 12 months, defined as the composite of cardiac death, target vessel myocardial infarction (TVMI), and clinically driven target vessel revascularization (TVR). At 30-day follow up, primary and secondary endpoints were comparable between the two groups.

One year after PCI, a total of 60 (4.2%) TVFs occurred, with 21 (2.9%) in the IVUS group and 39 (5.4%) in the angiography group (HR 0.530; 95% CI: 0.312-0.901; p=0.019). In lesion-level analyses, the IVUS group had a lower rate of target lesion revascularization (TLR) compared with the angiography group (0.9% vs. 2.3%, p=0.02). Despite the use of IVUS, 53% of patients met prespecified optimal criteria for stent implantation; in this group, TVF was 1.6%, compared with 4.4% in patients who failed to achieve all optimal IVUS criteria (HR 0.349; 95% CI: 0.135-0.898; p=0.029).

“The study demonstrated that IVUS-guided stent implantation significantly improved clinical outcomes in all-comers, particularly for patients who had an IVUS-defined optimal procedure, compared to angiography guidance,” said Junjie Zhang, MD, Vice Director of the Cardiovascular Department at Nanjing First Hospital in Nanjing Medical University (Nanjing, China). “While previous studies and this trial have demonstrated the overall favorable effect of IVUS guidance for patients with particular lesion subsets, this study further reports that achievement of IVUS-defined optimal PCI improves clinical outcomes for all-comers.”

The ULTIMATE trial was funded by the National Natural Science Foundation of China and was jointly supported by Six Talent Peaks Project in Jiangsu Province, Nanjing Health and Family Planning Commission, Nanjing Health Youth Talent Training project, and Nanjing Municipal Commission of Science & Technology. Dr. Zhang has no conflicts of interest.



Multicenter Study Finds IVUS-Guided Drug-Eluting Stent Implantation Improves Clinical Outcomes in All-Comer Patients - Cadiovascular Research Foundation

Junjie Zhang, Xiaofei Gao, Jing Kan, Zhen Ge, Leng Han, Shu Lu, Nailiang Tian, Song Lin, Qinghua Lu, Xueming Wu, Qihua Li, Zhizhong Liu, Yan Chen, Xuesong Qian, Juan Wang, Dayang Chai, Chonghao Chen, Xiaolong Li, Bill D. Gogas, Tao Pan, Shoujie Shan, Fei Ye and Shao-Liang Chen. Intravascular Ultrasound-Guided Versus Angiography-Guided Implantation of Drug-Eluting Stent in All-Comers: The ULTIMATE trial. J. Am. Coll. Cardiol. (2018). DOI: 10.1016/j.jacc.2018.09.013
 
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Landmark China cancer drug full approval ‘first of a wave’ | Business | Chemistry World
BY ANDY EXTANCE | 24 SEPTEMBER 2018

Chi-Med’s friquintinib is a result of China’s evolving drug innovation and regulation

China has granted the first full approval of a drug developed in the country to have been through modern clinical trials: the colorectal cancer treatment Elunate (friquintinib). Hong Kong-headquartered Hutchison China MediTech (Chi-Med) has worked on its drug since 2007, and has seven further candidates discovered by its chemists in Shanghai in clinical trials.

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Source: © Hutchison China MediTech​

China’s industry is trying to break from it’s poor reputation for innovation

‘It’s the beginning of a wave,’ Chi-Med chief executive Christian Hogg tells Chemistry World. ‘That wave is a result – in Hutchison China Meditech’s case – of 18 years of building a chemistry-driven research organisation in China around small molecules, focused on oncology and immunology.’

Industrial collaboration has also helped friquintinib in particular. In 2013, Chi-Med signed a partnership and licensing agreement with US-headquartered pharma giant Eli Lilly. Lilly funded a portion of fruquintinib’s clinical trials, and its sales representatives will now commercialise the potent, selective inhibitor of vascular endothelial growth factor receptors (VEGFR) 1, 2 and 3. Meanwhile, Shanghai-based WuXi Apptec will manufacture the fruquintinib active pharmaceutical ingredient (API), which Chi-Med will formulate into capsules in its newly built Suzhou facility.

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Source: © Hutchison China MediTech​

Chi-Med’s R&D teams in Shanghai have a further 7 candidates progressing through clinical trials

The API relationship is possible thanks to major moves by China to refine its drug regulation system. In 2016, the China Drug Administration (CDA) announced its Marketing Authorization Holder (MAH) programme, prior to which companies were required to own manufacturing facilities for the entire process. ‘If the quality of the drug candidate is high enough and the unmet medical need is large enough, you will be assigned MAH status, which fruquintinib was,’ Hogg says.

Also in 2016, the CDA announced a priority review programme for drugs developed in China to encourage innovation, which sped up fruquintinib’s approval. Despite recent controversies over drug and vaccine quality in China, Hogg stresses that he found the review process to be ‘extremely well-run from start to finish’. ‘The regulatory authorities in China are building out the organisation to far higher levels that have ever been in place before to give them the capacity to apply such rigour across the full spectrum of their responsibility.’

In 2018, the number of CDA employees increased to more than 1000, adds Calvin Niu, associate director of global regulatory affairs at US-headquartered PRA Health Sciences. ‘Three years ago, there were only 120 reviewers,’ Niu says. ‘The drug filing backlog was very serious at that time. The priority review system is definitely important as it can shorten the launch timeline.’

Niu agrees that fruquintinib ‘can be considered the beginning of a wave of drug innovation in China as a result of government reforms’ designed to encourage domestic discoveries. He notes that in 2017 there were 104 clinical trial applications and eight marketing applications for new small molecule drugs in China, the most in the past ten years.
 
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CChina-SL project to end CKDu launched | Daily News.lk
Friday, September 28, 2018 - 01:00
Disna Mudalige


Minister Rauff Hakeem. Picture by Siripala Halwala.

The construction of a state-of-the-art water testing laboratory will begin tomorrow at the Peradeniya University premises as a China-Sri Lanka joint project to finding a scientific solution to the Chronic Kidney Disease of Unknown Origin (CKDu).

The USD 20-million project is carried out with a Chinese grant of Rs. 1,950 million and a Rs. 880 million contribution from the Sri Lankan Government.

City Planning and Water Supply Minister Rauff Hakeem said the ‘China Sri Lanka Joint Research and Demonstration Centre for Water Technology’ would be the largest drinking water testing laboratory in South Asia.

He was addressing a press conference at the Government Information Department, yesterday.

The University of Peradeniya, Chinese Academy of Sciences and the City Planning and Water Supply Ministry are partners of the project, which includes a 5,000 square metre building with advanced technology. The project is expected to be completed by May 2020.

The minister said the project grant was a result of President Maithripala Sirisena’s visit to China in 2015.

The minister said the water testing laboratory together with the fully-fledged Nephrology Hospital in Polonnaruwa, being built with another Chinese grant, would help to deliver the President’s pre-election pledge to fight CKDu.

Chinese Academy of Sciences Vice President Hou Jianguo said this project is the first China-aided project in the field of science and technology in Sri Lanka.

The project construction was undertaken by China Tiesiju Civil Engineering Group Co., Ltd. (CTCE).

Responding to a question by a journalist, the minister said the Cabinet decided to set up a separate authority to protect the country’s water resources.

“At present, water bodies come under various institutions such as the Forest Conservation Department, Wildlife Department, Mahaweli Development Authority, Irrigation Department and National Water Supply and Drainage Board.

As the responsibilities are shared, the task has become difficult.

The new authority will act as the central body to protect the water resources,” said the minister. Peradeniya University Vice Chancellor Prof. Upul Dissanayake, Chinese Embassy in Sri Lanka Commercial Counselor Yang Zuoyuan and CTCE Board Chairman Zhang Hechuan were also present.

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China invests in new center in Sri Lanka to strengthen collaboration on marine sciences
Source: Xinhua| 2018-09-29 13:48:05|Editor: Yamei

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Photo taken on Sept. 27, 2018 shows the China-Sri Lanka Joint Centre for Education and Research (CSL-CER) at the University of Ruhuna (UOR) in Matara, Sri Lanka. Sri Lanka and China inaugurated a new building for the China-Sri Lanka Joint Centre for Education and Research (CSL-CER) at the University of Ruhuna (UOR), in southern Sri Lanka with the aim of strengthening marine science and research in the island country, the UOR said in a statement on Saturday. (Xinhua/Tang Lu)

COLOMBO, Sept. 29 (Xinhua) -- Sri Lanka and China inaugurated a new building for the China-Sri Lanka Joint Centre for Education and Research (CSL-CER) at the University of Ruhuna (UOR), in southern Sri Lanka with the aim of strengthening marine science and research in the island country, the UOR said in a statement on Saturday.

The CSL-CER is handled by the UOR and the South China Sea Institute of Oceanology, Chinese Academy of Sciences (CAS), an outcome of a national level cooperation agreement signed in 2014. It is also the CAS's first overseas research center on marine sciences.

According to the statement, the CAS has granted more than 20 Sri Lankan students to pursue their Phd/Master's degree on marine sciences in CAS's research institutes during the last three years.

The CAS along with the UOR and other Sri Lankan agencies will push this center to play a bigger role in the international cooperation on marine sciences and education in the Indian Ocean region.

Hou Jianguo, vice president of the Chinese Academy of Sciences, said the CAS will continue to promote comprehensive science and education cooperation with Sri Lanka using the newly launched ocean observation platform.

Acting Vice Chancellor of the UOR Nayana Alagiyawanna said the joint observation system of the tropical marine environment set up by the CAS and the UOR a few years ago had laid UOR on an important position in the field of marine research in Sri Lanka.
 
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Mapping of Chinese brain bold journey for science
By Zhou Wenting | China Daily | Updated: 2018-10-02 07:28

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Scientists are mapping Chinese people's brains to get a better understanding of how the influence of the Chinese language affects cognitive performance. [Photo/VCG]

Reading, writing in characters versus alphabet may create cognitive oddities

Scientists are mapping Chinese people's brains to get a better understanding of how the influence of the Chinese language affects cognitive performance, as well as to learn more about the mechanisms behind cerebral disorders.

Hospitals and universities in Shanghai and Shenzhen, Guangdong province, are the main participants in the joint study commissioned by the Shanghai Research Center for Brain Science and Brain-Inspired Intelligence. They will carry out clinical studies into brain development, cognitive learning processes and brain-related diseases, said Zhang Xu, vice-president of the Shanghai branch of the Chinese Academy of Sciences and executive director of the research center, in a recent interview with China Daily.

The center employs some of China's leading brain research experts, some of whom participated in the breakthrough cloning of two monkeys using somatic cells last year.

Bai Chunli, president of the CAS, said at the unveiling ceremony of the research center in May that brain science had become a popular international discipline in recent years, and the world's major technological powers have invested a lot of resources in the field of study.

The establishment of the research center is an important measure to strengthen the country's international status in the field.

The center was established "with the ultimate goal of gaining more understanding of the human brain and improving social development and people's well-being", Zhang said in the interview during the recent 2018 World Artificial Intelligence Conference in Shanghai.

Scientists in the United States are also working on human brain mapping, Zhang said. The Shanghai center will focus more on unique Chinese elements, such as the correlation and influence of the Chinese language and calligraphy on the brain, and the identification of functional areas and their roles in neural networks and disease.

Zhang said there has been scientific research demonstrating that the functional areas of the brain stimulated when speaking Chinese and English are different.

"There will also be brain research for infants and children to find answers to various questions, such as the best time to start language learning and whether the learning processes of children are different from those of adults," he said, adding that research groups in education and psychology will participate in such studies.
 
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NEWS | 02 OCTOBER 2018
China to train African scientists as part of $60-billion development plan
But critics worry the investment will make African countries too reliant on an outside power.

David Cyranoski

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An agricultural official from Namibia learns about technology to combat desertification at a Chinese lab.Credit: Chen Bin/Xinhua via Zuma

China wants to train Africa’s next generation of scientists. Its lofty goal is to improve African science in fields from agriculture and climate change to quantum physics and artificial intelligence.

The training is one element of a much larger plan adopted by Chinese and African leaders at the third Summit of the Forum on China–Africa Cooperation in Beijing last month. Chinese President Xi Jinping has pledged US$50 billion in grants and loans for infrastructure projects, medical programmes, clean-energy initiatives and other projects in Africa. Chinese companies will invest another $10 billion. The amount dedicated to training scientists is not known.

But some policy experts and scientists worry that African nations might become too reliant on other countries to provide training. Others doubt that the initiatives will truly boost African science, as similar projects planned at past forums have yet to produce noticeable benefits.

Few details have been released about how the money will be distributed among countries. But the division is likely to be controversial, says Lina Benabdallah, who studies Chinese foreign policy in Africa at Wake Forest University in Winston-Salem, North Carolina. “It will be up to African leaders, political elites and their constituents to press for specific programmes to happen,” she says.

Research training
Training is a pillar of the new plan. China will offer 50,000 scholarships for African people, including scientists, to study in China, and will provide short-term training opportunities for another 50,000 people to travel to seminars and workshops.

The action plan also offers scholarships for postgraduate training in China and at African institutions, such as the Sino-Africa Joint Research Centre at the Jomo Kenyatta University of Agriculture and Technology in Juja, Kenya. The centre, which opened in 2013, collaborates with Wuhan Botanical Garden in China and has produced dozens of academic papers in fields including biodiversity and climate-change monitoring.

China will also support a major expansion of the University of Health and Allied Sciences, a modern biomedical training institution in Ho, Ghana, which the country gave US$20 million in 2015.

“Developing indigenous talents locally is extremely important to the future of science in Africa,” says Tommy Karikari, a neurology researcher from Ghana who works at the University of Gothenburg in Sweden. The latest plan will dramatically expand training opportunities for African scientists, he says.

Karikari says that local scholarships and training facilities are important to ensure that some researchers stay in Africa. Many people currently train abroad because of a lack of opportunities on the continent, says Karikari. “It is expensive, and many beneficiaries do not return home, which affects the pool of trained scientists in Africa,” he says.

Benabdallah says the summit focused particularly on ways to include African scientists in China’s global diplomacy programme, the Belt and Road initiative. For example, the plan encourages researchers in Africa to join the Young Scientists Exchange Program, which pays for scientists to study in China for up to a year.

China has also promised to help countries develop real-world applications in quantum physics and artificial intelligence. But Benabdallah says there is a risk that African nations might become too dependent on other countries to provide training and skills. It is important for African nations to be producers of science and technology, not just consumers, she says.

Agriculture focus
The plan also reaffirms China’s decades-long commitment to help improve agricultural science and practices and environmental protection in Africa. Analysts characterize this investment as a mix of profit-seeking, philanthropy and food security, as China seeks grains and oilseeds that it can bring back home.

The plan calls for new centres for joint research in environmental issues and geoscience, although their locations are yet to be announced. Other programmes will focus on safeguarding biodiversity and combating climate change and desertification. Five hundred senior agriculture experts from China will also be sent to Africa to help modernize agricultural practices.

But Ademola Adenle, who studies sustainable development at Colorado State University in Fort Collins, is sceptical about China’s intentions. He says little knowledge has been gained from the more than 20 Chinese-government-funded agricultural-technology development centres created throughout Africa since 2006. The centres lack transparency and mainly represent Chinese commercial interests, he says. One of them reportedly sells farm equipment, mushroom powder and dried mushrooms to local people.

“Since this initiative kicked off, I am not aware of any significant breakthrough in agriculture research and development or any type of innovation that could transform agricultural development,” he says.

China's agriculture ministry did not respond to questions about the agricultural-technology centres by Nature's deadline.

Adenle hopes that the forum will result in training for agricultural scientists to improve local farming techniques. But if these initiatives just give China more access to Africa’s natural resources, it could spell doom for the continent, he says.

For China’s investments to help Africans harness science and technology, there will need to be more public discussion of the trade agreements and political deals as they're worked out. “There is no doubt that China has invested a lot of money in Africa,” he says. “But we need more transparency.”

Nature 562, 15-16 (2018)


China to train African scientists as part of $60-billion development plan | Nature.com
 
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Project leads countries to food security
By WANG XIAODONG | China Daily | Updated: 2018-10-04 02:30
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Photo/VCG
Green Super Rice initiative bringing African, Asian nations high-yield crops

Chinese agricultural researchers have helped plant more than 2 million hectares of superior rice species in more than a dozen Asian and African countries, yielding harvest increases of up to 30 percent per hectare in some, in an international cooperative project over the past 10 years.

The Green Super Rice project, geared at alleviating poverty through cultivation and promotion of a drought and disease resistant rice species, covers 16 Asian and African countries where rice is a staple, said Li Zhikang, a professor and researcher of rice breeding at the Chinese Academy of Agricultural Sciences, and a leading member of the project.

Working with authorities in the 16 countries, which include the Philippines, Vietnam, South Africa and Uganda, researchers have developed and introduced about 70 superior quality rice species, and dozens more are expected to be planted, he said.

In both the Philippines and Vietnam, about 700,000 hectares of new rice species have been planted. The new species, compared with those originally cultivated, have increased yields by 20 to 30 percent in both countries, Li said.

"Due to superior characteristics of the new species, such as being insect resistant, they require either no or less synthetic fertilizers, and that helps protect the environment," Li said. "With the planting of the new species, the concept of 'green rice' is also being promoted and gradually accepted."

The project, launched in 2008 and sponsored by the Chinese government and the Bill and Melinda Gates Foundation, is led by the Chinese Academy of Agricultural Sciences. It is China's largest international agri-technology cooperative project in recent years, Li said.

Chinese and international institutes — including the International Rice Research Institute in Manila, the Philippines; Africa Rice, in Abidjan, Cote d'Ivoire; and Huazhong Agricultural University in Wuhan, Hubei province — participated in the project, Li said.

"Many of the countries involved rely on imports because of insufficient agricultural production," Li said. "For example, the Philippines imports about 1 million metric tons of rice every year. By increasing harvest yields, the project can improve food security in these countries."

Li said the project is also beneficial to China, the world's biggest importer of grains, including rice. Last year, China imported 4 million metric tons and exported 1.2 metric tons of rice, according to the General Administration of Customs.

"Increased rice production in these countries can leave them with surpluses for export, which help to diversify China's rice imports and improves food security in China," he said.

Li said the project, which is due to end in March 2019, may be extended to cover more countries.

"Some other countries, like India, Bangladesh and Indonesia, have contacted us about taking part in the project," Li said.

"We hope for continued support for the project from the Chinese government in order to benefit more countries, including China," he said.

Contact the writer at wangxiaodong@chinadaily.com.cn
 
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