It is not completely impossible. We have been under US sanctions for 4 decades and we're still progressing in science and technology better than many countries who import the stuff they need from the US.
We do use US products like computer applications and other stuff, but you can always use pirated stuff when it comes to software.
I have the complete Adobe CC programs and I regularly update them without paying a penny to the US. The same goes to Windows and Microsoft Office or nearly any other software I need. Russians do the same.