Unless Americans have an unlikely change of heart and start getting deeply involved in Afghanistan again, I see no major threat from the Panjshiris at this point. I mean they are surrounded and this time there is no Russia and Iran to support them. India is not even a minor player in Afghanistan right now! I just wonder why Ahmad Shah Massoud's son would allow non-entity like A. Saleh to ruin Panjshir. Makes no sense.
BUT... if there is even a slight chance for some kind of 'base' of resistance in Panjshir then the Taliban should go after them and destroy and get Pakistan's covert help if needed. Nip in the bid, if necessary. Otherwise, in addition to hunting down ISIS and any left-over former Kabul Regime loyalists and placating militias along with governing a country which has lost its almost ALL income (the US $$), Taliban would also have to contend with an insurgency which would claim to be 'the legitimate' govt of Afghanistan.