Pakistan's Minorities Minister, Shahbaz Bhatti, has died after gunmen opened fire on his car in the capital, Islamabad, hospital officials say.
He was travelling to work through a residential district when his vehicle was sprayed with bullets, police said.
Mr Bhatti, a Christian, had received death threats after calling for changes to the controversial blasphemy law.
In January, Punjab Governor Salman Taseer, who had also opposed the law, was shot dead by one of his bodyguards.
The blasphemy law carries a death sentence for anyone who insults Islam. Critics say it has been used to persecute minority faiths.
'Concerted campaign'
Mr Bhatti, 42, a leader of the ruling Pakistan People's Party (PPP), had just left his home in the capital when at least two gunmen ambushed his car, police official Mohammad Iqbal said.
He was rushed to the nearby Shifa hospital, but was dead on arrival, Dr Azmatullah Qureshi told the AFP news agency.
The gunmen escaped in a car after the attack, witnesses said.
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This is concerted campaign to slaughter every liberal, progressive and humanist voice in Pakistan”
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Farahnaz Ispahani
Pakistan presidential aide
Television footage showed Mr Bhatti's vehicle riddled with bullet holes. Reports said it did not have a security escort.
No group has said it was behind the attack, but leaflets issued by Tehrik-i-Taliban Punjab, a branch of the Taliban in Pakistan's most populous province, were found at the ambush site, according to the private TV channel Express 24/7.
Security has been stepped up on all main roads in Islamabad.
In January, Mr Bhatti told the BBC he would defy death threats he had received from Islamist militants for his efforts to reform the blasphemy law.
"I was told that if I was to continue the campaign against the blasphemy law, I will be assassinated. I will be beheaded. But forces of violence, forces of extremism cannot harass me, cannot threaten me," he said.
A government spokesman condemned the assassination.
"This is concerted campaign to slaughter every liberal, progressive and humanist voice in Pakistan," Farahnaz Ispahani, an aide to President Asif Ali Zardari, told the Associated Press.
"The time has come for the federal government and provincial governments to speak out and to take a strong stand against these murderers to save the very essence of Pakistan."
http://www.bbc.co.uk/news/world-south-asia-12617562