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Rice first domesticated in China at about 10,000 years ago: study
Source: Xinhua | 2017-05-30 06:05:35 | Editor: huaxia

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Farmers transplant riceseedlings into paddy field in Dawa District of Panjin, northeast China's Liaoning Province, May 18, 2017. (Xinhua/Long Lei)

WASHINGTON, May 29 (Xinhua) -- Rice, one of the world's most important staple foods sustaining more than half of the global population, was first domesticated in China about 10,000 years ago, a new study suggested Monday.

"Such an age for the beginnings of rice cultivation and domestication would agree with the parallel beginnings of agriculture in other regions of the world during a period of profound environmental change when the Pleistocene was transitioning into the Holocene," Lu Houyuan, professor of the Institute of Geology and Geophysics at the Chinese Academy of Sciences, who led the study, said.

The research, published in the U.S. Proceedings of the National Academy of Sciences, was done in collaboration with Zhejiang Provincial Institute of Relics and Archaeology and the Institute of Geographic Sciences and Natural Resources Research at the Chinese Academy of Sciences.

Questions surrounding the origin and domestication of rice have led to a lot of debate in the last decade.

Rice remains have previously been recovered from the Shangshan site in the Lower Yangtze of China and recognized as the earliest examples of rice cultivation.

However, the age of the rice fossils was derived through radiocarbon dating of organic matter in pottery shards, which can be contaminated with older carbon sources, Lu said.

To constrain the age of the phytoliths, the researchers developed new ways of isolating rice phytoliths from carbon sources, such as clays and carbonate, and dated the samples directly using radiocarbon dating.

It turned out that phytoliths retrieved from the early stage of the Shangshan site are about 9,400 years old.

Further studies showed that approximately 36 percent of rice phytoliths at Shangshan had more than nine fish-scale decorations, less than the approximately 67 percent counted from modern domesticated rice, but larger than the approximately 17 percent found in modern wild rice.

That means that rice domestication may have begun at Shangshan at about 10,000 years ago during the beginning of the Holocene, when taking into account the distance between phytolith samples and the lowest bottom of cultural strata of the site as well as a slow rate of rice domestication, Lu said.

The time coincided with the domestication of wheat in the Near East and maize in northern South America, both of which are also believed to have occurred at about 10,000 years ago, when the global climate experienced dramatic changes from cold glacial to warm interglacial.
 
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Trials of embryonic stem cells to launch in China
Studies to treat vision loss and Parkinson’s disease are the first to proceed under new regulations.
In the next few months, surgeons in the Chinese city of Zhengzhou will carefully drill through the skulls of people with Parkinson’s disease and inject 4 million immature neurons derived from human embryonic stem cells into their brains. Then they will patch the patients up, send them home and wait.

This will mark the start of the first clinical trial in China using human embryonic stem (ES) cells, and the first one worldwide aimed at treating Parkinson’s disease using ES cells from fertilized embryos. In a second trial starting around the same time, a different team in Zhengzhou will use ES cells to target vision loss caused by age-related macular degeneration.

The experiments will also represent the first clinical trials of ES cells under regulations that China adopted in 2015, in an attempt to ensure the ethical and safe use of stem cells in the clinic. China previously had no clear regulatory framework, and many companies had used that gap as an excuse to market unproven stem-cell treatments.

“It will be a major new direction for China,” says Pei Xuetao, a stem-cell scientist at the Beijing Institute of Transfusion Medicine who is on the central-government committee that approved the trials. Other researchers who work on Parkinson’s disease, however, worry that the trials might be misguided.

Both studies will take place at the First Affiliated Hospital of Zhengzhou University in Henan province. In the first, surgeons will inject ES-cell-derived neuronal-precursor cells into the brains of individuals with Parkinson’s disease. The only previous trial using ES cells to treat Parkinson’s began last year in Australia; participants there received stem cells from parthenogenetic embryos — unfertilized eggs that are triggered in the lab to start embryonic development.

In the other Zhengzhou trial, surgeons will take retinal cells derived from ES cells and transplant them into the eyes of people with age-related macular degeneration. The team will follow a similar procedure to that of previous ES-cell trials carried out by researchers in the United States and South Korea.

Qi Zhou, a stem-cell specialist at the Chinese Academy of Sciences Institute of Zoology in Beijing, is leading both efforts. For the Parkinson’s trial, his team assessed hundreds of candidates and have so far have picked ten who best match the ES cells in the cell bank, to reduce the risk of the patients’ bodies rejecting the cells.

---> Trials of embryonic stem cells to launch in China : Nature News & Comment
 
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Xinhua Insight: China's AI business ready to lead the world
Source: Xinhua| 2017-06-01 11:08:02|Editor: Hou Qiang



BEIJING, June 1 (Xinhua) -- Over the past week, the Internet has yet again been buzzing about the future of artificial intelligence (AI).

And once again, the heat was generated by AlphaGo, Google's AI program, which completed a 3-0 clean sweep Friday over Ke Jie, the current world No.1 Go player.

In contrast to the generally negative reactions to AlphaGo's 4-1 victory over South Korean master Lee Se-dol in March last year, people are now more optimistic towards the future of AI.

"AlphaGo was not designed just to play Go," said Qian Jianlun, a Go teacher in east China's Zhejiang Province. "As an AI project, it will change a lot of aspects of our lives."

FULL SPEED AHEAD

Qian's words echoed the overall positivity shown by the status quo of China's AI industry.

According to data from iiMedia Research, a major research institution, China's AI industry increased by 43.3 percent in 2016, surpassing 10 billion yuan (1.47 billion U.S. dollars), and is expected to reach 15.21 billion and 34.43 billion yuan in 2017 and 2019 respectively.

The numbers were driven by a boom in the amount of research taking place in the industry. China has applied for 15,745 AI patents, ranking second worldwide, according to Liu Lihua, vice minister of industry and information technology.

Favorable policies came as a consequence. Over 40 robotics industry parks have now been or are currently being set up around the country, and for the first time ever, AI was included in the government work report Premier Li Keqiang presented to the Fifth Session of the 12th National People's Congress in March.

"We will accelerate research and development, and commercialization of new materials, artificial intelligence [...] and develop industrial clusters in these fields," the report read.

"AI has become a key driving force behind Chinese companies," said Zhang Yaqin, president of Baidu, China's Internet giant.

"In the AI era, China can innovate not only in products, but also in technologies," he added.

DATA SET THE BASE

For insiders, the further development of China's AI industry will continue to count largely on data.

"The core of AI development lies in the massive amounts of data," said Li Kaifu, chairman and CEO of Sinovation Ventures, a venture capital company aiming to create successful Chinese start-ups.

"In China, we have a huge database, and it has proved to be quite valuable for us," he continued.

Bai Chunli, president of Chinese Academy of Sciences, agreed. "By 2020, China will hold 20 percent of the global data, which is expected to reach 44 trillion gigabytes," he stated at an expo on big data Monday.

AI has been playing a bigger role in people's everyday lives. For example, an AI system monitoring vehicles to intelligently control traffic was applied in east China's Hangzhou, and increased vehicle passing speeds by up to 11 percent during its trial last year.

"China is already leading the world in fields such as computer vision and automatic speech recognition," Liu Lihua added.

"We believe that AI presents the most favorable opportunity for us to lead the world," Li resonated.

BUSINESS YET TO UNITE

However, for some, what has been transpiring in the industry is not enough for it to successfully achieve sustainable development.

Despite predicting that China's AI market will enjoy a 50-percent annual increase, way above the global rate of 20 percent, McKinsey and Company, a worldwide management consulting firm, also noted that less than 25 percent of the AI industry insiders in China have over ten years of experience in the business, while in the United States that number is 50 percent.

Also, the country's AI companies are yet to join forces.

"There's been a lack of technical collaboration in our AI industry," said Wen Xiaojun from CCID Wise, a major Chinese think tank. "The inter-connectibility of products is poor, and there is no efficient coordination between upstream and downstream producers."

He believes an industry service platform needs to be set up to boost functions including research and development, application and product examining.

"We need such an incubation center for AI to prosper," he added.
 
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Interview: China-Australia research team develops new software for early cancer detection
Source: Xinhua| 2017-05-31 13:49:55|Editor: Hou Qiang


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Image provided by CSIRO shows comparison of the enhanced blood vessel prior to skeletonisation (LHS) (left) and after the end-point skeletonisation process (RHS) (right). A team of Australian and Chinese scientists have developed sophisticated new software which could play a key role in the early detection of cancer. Australia's Commonwealth Scientific and Industrial Research Organisation (CSIRO) released a statement on Wednesday saying the partnership has developed an algorithm which detected the formation of new blood vessels, known to precede the growth of cancers, in mice. (Xinhua/CSIRO)

CANBERRA, May 31 (Xinhua) -- A team of Australian and Chinese scientists have developed sophisticated new software which could play a key role in the early detection of cancer.

Australia's Commonwealth Scientific and Industrial Research Organisation (CSIRO) released a statement on Wednesday saying the partnership has developed an algorithm which detected the formation of new blood vessels, known to precede the growth of cancers, in mice.

CSIRO's Data61 researchers joined forces with researchers at the Shanghai Institute of Applied Physics, Chinese Academy of Sciences to analyse images of the brains and livers of mice at different stages of cancer growth.

Together, the team looked at high-resolution 3D micro-CT images produced by the Shanghai Synchrotron Radiation Facility (SSRF) of 26 mice.

These images helped the researchers develop the algorithm which discovered the formation of new blood vessels. The scientists are hopeful that earlier detection of blood vessel growth could lead to a faster diagnosis of malignant tumor growth, a key factor in successful treatment and patient survival.

"In the past people were just able to get a rough idea but, with new technology, we are able to see the microvasculature which are very fine structures," Dr Wang Dadong, lead researcher on the project, told Xinhua on Wednesday.

While the research marks a significant step forward in cancer detection, the Shanghai Synchrotron Beamline used to produce the images generates radiation levels not safe for humans.

Wang told Xinhua he was unsure how long it will take before this new detection method is safe for human application.

"The technology is moving forward very fast, but we are still looking for a safe life source for human trial. Our software is being packaged, and it's ready for trial, we're just looking for partners to do the trials," Wang said.

In order to progress clinical trials on humans, the researchers are looking for 3D imaging technologies and partnering with a hardware manufacturer that can produce high-resolution images with levels of radiation safe for humans.

"But we are very hopeful, and currently looking for collaborators and partners to take the technology to the next stage," said Wang.
 
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A material that can switch between multiple phases that have distinct electronic, optical and magnetic properties
June 1, 2017 by Bob Yirka

(Phys.org)—A large team of researchers with members from China, the U.K., the U.S. and Japan has developed a material that can switch between multiple phases with distinct electronic, optical and magnetic properties. In their paper published in the journal Nature, the team describes how they made their material, how it can be caused to switch properties and possible uses for it. Shriram Ramanathan, with Purdue University offers a News & Views piece on the work done by the team in the same journal issue and adds some additional background on the search for functional materials.

---> https://phys.org/news/2017-06-material-multiple-phases-distinct-electronic.html

Nianpeng Lu, Pengfei Zhang, Qinghua Zhang, Ruimin Qiao, Qing He, Hao-Bo Li, Yujia Wang, Jingwen Guo, Ding Zhang, Zheng Duan, Zhuolu Li, Meng Wang, Shuzhen Yang, Mingzhe Yan, Elke Arenholz, Shuyun Zhou, Wanli Yang, Lin Gu, Ce-Wen Nan, Jian Wu, Yoshinori Tokura & Pu Yu. Electric-field control of tri-state phase transformation with a selective dual-ion switch, Nature (2017). DOI: 10.1038/nature22389.

Abstract

Materials can be transformed from one crystalline phase to another by using an electric field to control ion transfer, in a process that can be harnessed in applications such as batteries, smart windows and fuel cells. Increasing the number of transferrable ion species and of accessible crystalline phases could in principle greatly enrich material functionality. However, studies have so far focused mainly on the evolution and control of single ionic species (for example, oxygen, hydrogen or lithium ions). Here we describe the reversible and non-volatile electric-field control of dual-ion (oxygen and hydrogen) phase transformations, with associated electrochromic2 and magnetoelectric11 effects. We show that controlling the insertion and extraction of oxygen and hydrogen ions independently of each other can direct reversible phase transformations among three different material phases: the perovskite SrCoO3−δ, the brownmillerite SrCoO2.5, and a hitherto-unexplored phase, HSrCoO2.5. By analysing the distinct optical absorption properties of these phases, we demonstrate selective manipulation of spectral transparency in the visible-light and infrared regions, revealing a dual-band electrochromic effect that could see application in smart windows. Moreover, the starkly different magnetic and electric properties of the three phases—HSrCoO2.5 is a weakly ferromagnetic insulator, SrCoO3−δ is a ferromagnetic metal, and SrCoO2.5 is an antiferromagnetic insulator—enable an unusual form of magnetoelectric coupling, allowing electric-field control of three different magnetic ground states. These findings open up opportunities for the electric-field control of multistate phase transformations with rich functionalities.​
 
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Solar-powered craft can drone on for months, reaches new high
By Zhao Lei | China Daily | Updated: 2017-06-02

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The Caihong drone flew over 20,000 meters high. [Photo provided to China Daily]

China's largest and most advanced solar-powered unmanned aircraft has set a domestic record for flight ceiling by reaching an altitude of over 20,000 meters, according to its designer.

The Caihong, or Rainbow, solar-powered drone, developed by the China Academy of Aerospace Aerodynamics, set the record during a test flight last week at an unidentified airport in Northwest China. It flew at an altitude of 20,000 meters long enough for the flight to be classified as a success, Shi Wen, head of unmanned aircraft development at the academy, said in an exclusive interview on Thursday.

He said the drone took off in the morning and flew back to the airport late at night. It will take several years for designers and engineers to improve and test the aircraft before it is delivered to users.

The aircraft is able to fly above a large area and features flexibility and good economy. Future improvements will enable it to remain aloft several months or even several years. Potential buyers mainly will be government departments and companies involved in communications, internet, Earth observation, emergency response and marine survey and inspection, according to Shi.

He declined to reveal the size of the drone, but earlier reports said a similar type aircraft developed by his team was 14 m long with a 45 m wingspan.

The designer explained that normally, a fuel-powered military drone can fly to a maximum altitude of up to 8,000 m while a handful of top surveillance drones like the Northrop Grumman RQ-4 Global Hawk in the United States are capable of reaching altitudes of 18,000 m.

In the category of solar-powered drones, Chinese institutes have developed some experimental models, but they are smaller and technologically unsophisticated compared with the Caihong, and their highest operational altitudes are at thousands of meters, Shi said.

His comments were echoed by Wang Yangzhu, president of Beihang University's Unmanned System Institute and a senior drone expert. Wang said Beihang University in Beijing, Nanjing University of Aeronautics and Astronautics in Jiangsu province and Northwestern Polytechnical University in Shaanxi province had made experimental, solar-powered drones to verify technologies and their types "could hardly fly any higher than 10,000 m".

"Therefore, the Caihong has made a remarkable achievement," Wang noted.

Shi said the higher a solar-powered drone can fly, the longer it is able to remain in the sky because there are no clouds 20,000 m above the ground and the airflow there is stable. Thus, the drone can fully use its solar cells to generate power. As long as the solar power system works well, the aircraft can stay in the air as long as the controllers wish.

Previously, the US and United Kingdom developed solar-powered drones capable of flying as high as 20,000 m. The altitude record for a solar-powered drone, 29,524 m, was made by the US Helios Prototype, developed by AeroVironment Inc in California, in August 2001.

Drones made by the China Academy of Aerospace Aerodynamics have been used in more than 10 foreign countries, according to the academy.

http://www.chinadaily.com.cn/business/tech/2017-06/02/content_29585157.htm
 
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Solar-powered craft can drone on for months
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China's largest and most advanced solar-powered unmanned aircraft has set a domestic record for flight ceiling by reaching an altitude of over 20,000 meters, according to its designer. The Caihong, or Rainbow, solar-powered drone, developed by the China Academy of Aerospace Aerodynamics, set the record during a test flight last week at an unidentified airport in Northwest China. It flew at an altitude of 20,000 meters long enough for the flight to be classified as a success, Shi Wen, head of unmanned aircraft development at the academy, said in an exclusive interview on June 1, 2017. He said the drone took off in the morning and flew back to the airport late at night. It will take several years for designers and engineers to improve and test the aircraft before it is delivered to users. (Photo/Weibo account of CCTV)


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http://china.org.cn/photos/2017-06/02/content_40947595.htm
 
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New ceramic nanofiber ‘sponges’ could be used for flexible insulation, water purification
June 2, 2017 Contact: Kevin Stacey 401-863-3766

Ceramic materials tend to shatter when deformed, but new research shows a way of using ultra-thin ceramic nanofibers to make squishy, heat-resistant sponges with a wide variety of potential uses.


PROVIDENCE, R.I. [Brown University] — Researchers have found a way to make ultralight sponge-like materials from nanoscale ceramic fibers. The highly porous, compressible and heat-resistant sponges could have numerous uses, from water purification devices to flexible insulating materials.

“The basic science question we tried to answer is how can we make a material that’s highly deformable but resistant to high temperature,” said Huajian Gao, a professor in Brown University’s School of Engineering and a corresponding author of the research. “This paper demonstrates that we can do that by tangling ceramic nanofibers into a sponge, and the method we use for doing it is inexpensive and scalable to make these in large quantities.”

The work, a collaboration between Gao’s lab at Brown and the labs of Hui Wu and Xiaoyan Li at Tsinghua University in China, is described in the journal Science Advances.

As anyone who has ever dropped a flower vase knows well, ceramics are brittle materials. Cracks in ceramics tend to propagate quickly, leading to catastrophic failure with even the slightest deformation. While that’s true for all traditional ceramics, things are different at the nanoscale.

“At the nanoscale, cracks and flaws become so small that it takes much more energy to activate them and cause them to propagate,” Gao said. “Nanoscale fibers also promote deformation mechanisms such as what is known as creep, where atoms can diffuse along grain boundaries, enabling the material to deform without breaking.”

Because of those nanoscale dynamics, materials made from ceramic nanofibers have the potential to be deformable and flexible, while maintaining the heat resistance that make ceramics useful in high-temperature applications. The problem is that such materials aren’t easy to make. One often-used method of making nanofibers, known as electrospinning, doesn’t work well with ceramics. Another potential option, 3-D laser printing, is expensive and time-consuming.


So the researchers used a method called solution blow-spinning, which had been developed previously by Wu in his lab at Tsinghua. The process uses air pressure to drive a liquid solution containing ceramic material through a tiny syringe aperture. As the liquid emerges, it quickly solidifies into nanoscale fibers that are collected in a spinning cage. The collected material is then heated, which burns away the solvent material leaving a mass of tangled ceramic nanofibers that looks a bit like a cotton ball.

The researchers used the method to create sponges made from a variety of different types of ceramics and showed that the materials had some remarkable properties.

For example, the sponges were able to rebound after compressive strain up to 50 percent, something that no standard ceramic material can do. And the sponges can maintain that resilience at temperatures up to 800 degrees Celsius.

The research also showed that the sponges had a remarkable capacity for high-temperature insulation. In one experiment, the researchers placed a flower petal on top of 7-millimeter-thick sponge made from titanium dioxide (a common ceramic material) nanofibers. After heating the bottom of the sponge to 400 degrees Celsius for 10 minutes, the flower on top barely wilted. Meanwhile, petals placed on other types of porous ceramic materials under the same conditions were burnt to a crisp.

The sponges’ heat resistance and its deformability make them potentially useful as an insulating material where flexibility is important. For example, Gao says, the material could be used as an insulating layer in firefighters’ clothing.

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Ceramic nanofiber sponges retain the heat resistance that makes ceramics useful in high-temperature applications. They even outperform other ceramic materials (Al2O3) in insulating at temperature around 400 degrees C.

Another potential use could be in water purification. Titanium dioxide is a well-known photocatalyst used to break down organic molecules, which kills bacteria and other microorganisms in water. The researchers showed that a titanium dioxide sponge could absorb 50 times its weight in water containing an organic dye. Within 15 minutes, the sponge was able to degrade the dye under illumination. With the water wrung out, the sponge could then be reused — something that can’t be done with the titanium dioxide powders normally used in water purification.

In addition to these, there may be other applications for ceramic sponges that the researchers haven’t yet considered.

“The process we used for making these is extremely versatile; it can be used with a great variety of different types of ceramic starting materials,” said Wu, one of the corresponding authors from Tsinghua. “So we think there’s huge prospect for potential applications.”

The work was supported by the National Basic Research Program of China, the National Natural Science Foundation of China, the Chinese Program for New Century Excellent Talents in University and the U.S. National Science Foundation (CMMI-1634492).


New ceramic nanofiber ‘sponges’ could be used for flexible insulation, water purification | News from Brown


Wang, H., Zhang, X., Wang, N., Li, Y., Feng, X., Huang, Y., Zhao, C., Liu, Z., Fang, M., Ou, G., Gao, H., Li, X., Wu, H. "Ultralight, scalable, and high-temperature–resilient ceramic nanofiber sponges". Science Advances (2017). DOI: 10.1126/sciadv.1603170
 
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Chinese scientists find possible cell therapy for multiple myeloma
Source: Xinhua| 2017-06-06 05:03:09|Editor: yan



CHICAGO, June 5 (Xinhua) -- Chinese scientists presented a possible cell therapy for multiple myeloma at the 2017 annual meeting of the American Society of Clinical Oncology (ASCO) held here in Chicago on Monday.

Data collected by Chinese scientists in an early clinical trial show that the therapy, called chimeric antigen receptor (CAR) T-cell immunotherapy, could be a safe and effective way to treat relapsed or refractory multiple myeloma.

The ongoing early-phase clinical trial of the therapy conducted at the Second Affiliated Hospital of Xi'an Jiaotong University in Xi'an, China, shows that 33 out of 35 patients who have their multiple myeloma relapsed on previous treatments reported clinical remission within two months after receiving experimental CAR T-cell products targeting B-cell maturation protein (BCMA).

The first 35 patients enrolled in the ongoing clinical trial have received three split doses of 20 percent, 30 percent and 50 percent, respectively, over a week, and the first signs of treatment efficacy appeared as early as 10 days after the initial injection.

During clinical trial, Chinese researchers have followed 19 patients for more than four months, a consensus criteria time for full efficacy assessment set by the International Myeloma Working Group (IMWG), and found that 14 reached stringent complete response (sCR) criteria, which means there is no detectable plasma cells in the patient's bone marrow or myeloma proteins in the serum or urine; one reached partial response; and four achieved very good partial remission criteria (VgPR) in efficacy.

There has not been a single case of relapse among the 14 patients who reached sCR criteria, and of the five out of the 14 patients that have been followed for over a year, all remain at sCR status.

Clinical trial also found that cytokine release syndrome (CRS), a common and potentially dangerous side effect of ACR T-cell, occurred in 85 percent of patients receiving the therapy, though the symptoms were mild and manageable in majority of the cases.

Michael S. Sabel, fellow of the America College of Surgeons, called the trial of the therapy and the science behind it "revolutionary". "I think this really opens up the door for using the sort of precision immunotherapy to expand the potential of immunotherapy to a wider net of patients," Sabel said.

Wanhong Zhao, a main organizer of the current study on CAR T-cell and associate director of hematology at the Second Affiliated Hospital of Xi'an Jiaotong University, compared the cancer to a ball, saying the therapy in the past was to use one hand to catch the ball, which is prone to fail.

"The new therapy enables us to use two hands to grasp the ball," which can hold the ball tight and then kill it, Zhao said.

Frank Fan, chief scientific officer and founder of Legend Biotech, told Xinhua that this new therapy his company developed in the past three years is a unique one in the world, and Legend Biotech claims full intellectual property right over it.

Multiple myeloma is a cancer of plasma cells from bone marrow. It is not really responding to standard chemotherapies. Nearly 86,000 patients are diagnosed with myeloma each year, and the number may continue to increase as the world population is aging. The disease usually occurs above 60 years old and is more common in men than women.

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Durable remissions with BCMA-specific chimeric antigen receptor (CAR)-modified T cells in patients with refractory/relapsed multiple myeloma.

Author(s): Frank (Xiaohu) Fan, Wanhong Zhao, Jie Liu, Aili He, Yinxia Chen, Xingmei Cao, Nan Yang, Baiyan Wang, Pengyu Zhang, Yilin Zhang, Fangxia Wang, Bo Lei, Liufang Gu, Xugeng Wang, Qiuchuan Zhuang, Wanggang Zhang; Nanjing Legend Biotech, Nanjing, China; Hematology, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi'an, China

Abstract:

Background:
Chimeric antigen receptor engineered T cell (CAR-T) is a novel immunotherapeutic approach for cancer treatment and has been clinically validated in the treatment of acute lymphoblastic leukemia (ALL). Here we report an encouraging breakthrough of treating multiple myeloma (MM) using a CAR-T designated LCAR-B38M CAR-T, which targets principally BCMA. Methods: A single arm clinical trial was conducted to assess safety and efficacy of this approach. A total of 19 patients with refractory/relapsed multiple myeloma were included in the trial. The median number of infused cells was 4.7 (0.6 ~ 7.0) × 10e6/ kg. The median follow-up times was 208 (62 ~ 321) days. Results: Among the 19 patients who completed the infusion, 7 patients were monitored for a period of more than 6 months. Six out of the 7 achieved complete remission (CR) and minimal residual disease (MRD)-negative status. The 12 patients who were followed up for less than 6 months met near CR criteria of modified EBMT criteria for various degrees of positive immunofixation. All these effects were observed with a progressive decrease of M-protein and thus expected to eventually meet CR criteria. In the most recent follow-up examination, all 18 survived patients were determined to be free of myeloma-related biochemical and hematologic abnormalities. One of the most common adverse event of CAR-T therapy is acute cytokine release syndrome (CRS). This was observed in 14 (74%) patients who received treatment. Among these 14 patients there were 9 cases of grade 1, 2 cases of grade 2, 1 case of grade 3, and 1 case of grade 4 patient who recovered after treatments. Conclusions: A 100% objective response rate (ORR) to LCAR-B38M CAR-T cells was observed in refractory/relapsed myeloma patients. 18 out of 19 (95%) patients reached CR or near CR status without a single event of relapse in a median follow-up of 6 months. The majority (14) of the patients experienced mild or manageable CRS, and the rest (5) were even free of diagnosable CRS. Based on the encouraging safety and efficacy outcomes, we believe that our LCAR-B38M CAR-T cell therapy is an innovative and highly effective treatment for multiple myeloma.


Durable remissions with BCMA-specific chimeric antigen receptor (CAR)-modified T cells in patients with refractory/relapsed multiple myeloma. | 2017 ASCO Annual Meeting Abstracts
 
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A Chinese hospital announced on Tuesday that doctors have recreated a breast for a cancer patient using "4D" printing.

The surgery was performed on August 8, 2016, and the printed breast has grown well with the patient's own tissue, said Ling Rui, a vascular surgery doctor with Xijing Hospital of the Fourth Military Medical University in Xi'an, Shaanxi Province.

The patient underwent a mastectomy for her left breast last year, before having the surgery.

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A doctor (L) showing the material used for breast stuffing, with the patient (R) who successfully undertook the surgery. /Xinhua Photo

"Compared with three-dimensional printing, 4D printing adds time as another dimension," said Ling.

Doctors collected data on the size of her tumor and original breast, and reconstructed a bio-degradable breast.

The implant was developed by the hospital with a national lab of Xi'an Jiaotong University.

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A researcher from the team explains how a breast can be reconstructed using 4D printing. /Xinhua Photo

"It is sufficiently strong, and will degrade in designed period of time, which is in the patient's case one to two years," said Zhang Juliang, an assistant professor in Xijing Hospital who participated in the surgery.

Its porous nature allows human tissue to grow into the implant and ultimately replace it, Zhang said.

"In the 10 months since the surgery, the implant has grown well, and the patient's veins and tissue have started to grow back," Ling said.

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A doctor showing the material used for breast reconstruction. /Xinhua Photo

Compared to existing methods of breast reconstruction, the method has fewer side effects, Ling said.

(Source: Xinhua)


https://news.cgtn.com/news/3d63544e3445444e/share_p.html
 
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A researcher from the team explains how a breast can be reconstructed using 4D printing. /Xinhua Photo

"It is sufficiently strong, and will degrade in designed period of time, which is in the patient's case one to two years," said Zhang Juliang, an assistant professor in Xijing Hospital who participated in the surgery.

Its porous nature allows human tissue to grow into the implant and ultimately replace it, Zhang said.

"In the 10 months since the surgery, the implant has grown well, and the patient's veins and tissue have started to grow back," Ling said.

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A doctor showing the material used for breast reconstruction. /Xinhua Photo

Compared to existing methods of breast reconstruction, the method has fewer side effects, Ling said.

(Source: Xinhua)


https://news.cgtn.com/news/3d63544e3445444e/share_p.html
These guys look like military doctors.
 
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So for years I am 4D printing stuff at my home with this. Width, lenght, depth and " time " :D

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