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China’s genomics giant to make stock-market debut
Once the world's biggest DNA sequencer for research, BGI is now looking to medical applications to boost profits.
BGI in Shenzhen has shifted its focus from serving researchers to medical applications of genome sequencing.

China’s genomics giant BGI, once the world leader in DNA sequencing for basic science, is going public — capping off a dramatic transformation into a mainly biomedical firm with a focus on reproductive health.

A financial prospectus document released to support the initial public offering (IPO) details how BGI, squeezed by its rivals and the plummeting cost of sequencing, has been drawn to more-profitable pursuits, such as prenatal genetic testing, in China’s expanding medical market. The shift is also in line with the Chinese government’s multibillion-yuan drive to promote precision medicine, an effort to use the reams of genomic and other medical data being created to tailor treatments.


China’s genomics giant to make stock-market debut : Nature News & Comment
China's genomics company BGI makes stock market debut
Source: Xinhua| 2017-07-14 14:12:25|Editor: ZD



BEIJING, July 14 (Xinhua) -- China's genomics giant BGI made its initial public offering (IPO) Friday on the Shenzhen Stock Exchange, with shares surging by the upper limit shortly after its debut.

With an initial offering price of 13.64 yuan (2 U.S. dollars), the company's share jumped more than 32 percent shortly after the market opening, triggering a temporary suspension on trading, before the share prices jumped again to reach the upper limit of 19.64 yuan after trading resumed.

According to market rules, share prices of stocks on their first day of trading on the Shenzhen Stock Exchange should not exceed 144 percent of the initial offering price.

Founded in 1999, the gene sequencing firm offers a wide portfolio of genetic testing products across major diseases, enabling medical providers and patients worldwide to realize the promise of genomics-based diagnostics and personalized healthcare.

BGI's services and solutions are available in more than 60 countries and regions around the world, according to the company's website.

In 2016, the company made revenues of 1.71 billion yuan (about 252 million U.S. dollars) and net profits of 332.69 million yuan, according to filings on the exchange.

According to TF Securities, China's gene sequencing market has seen rapid growth and the market size has reached around 5.4 billion yuan in 2016, and will likely exceed 10 billion yuan by 2020.

The compound annual growth rate of the industry will be around 20 to 25 percent, among the fastest rates around the world, it said.
 
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Focus: Graphene Sliding on Graphene
July 17, 2017• Physics 10, 81
Creating a bulge in a graphene sheet offers the first measurement of the shear forces between graphene layers, an essential factor in many graphene-based devices.

L. Liu, C. Weng, & G. Wang/NCNST
Bubble wrap. This cutaway shows the bulging that occurs when air is pumped through a hole underneath a graphene sheet. Researchers estimated the shear resistance by measuring the stretching in the sheet around the hole. The stretching for bilayer graphene (blue) is much larger than that for monolayer graphene (yellow).


Graphene, the single-atom-thick, sheet-like super-material of the past decade is now being used in multiple layers as part of high-strength composites and a range of electronic devices. One important challenge for this developing industry is the lack of information on the stickiness between layers of graphene or between graphene and another surface. A new experiment measured the maximum sticking force, or shear resistance, between two layers by determining the shape of the bulge produced by an air bubble blown up from beneath the surface. The analysis found that graphene layers adhere to each other very weakly—40 times less than they do to an underlying surface of silicon dioxide.

A single layer of graphene is composed of carbon atoms arranged in a two-dimensional honeycomb pattern. When stacked on top of another layer or surface, the graphene forms only a weak attachment, which is why it is often used as a lubricant [1]. Knowing precisely graphene’s stickiness is crucial for the new crop of multilayer graphene products, such as battery anodes, transistors, and displays, says Zhong Zhang from the National Center for Nanoscience and Technology (NCNST) in Beijing. For example, nanocomposites made from a combination of graphene and plastic can potentially fail if graphene layers suddenly slip away from each other.

To measure the shear resistance between two materials, one might apply a shear stress by creating a sandwich of the two and pulling the top material sideways while holding the bottom one still. The shear resistance would correspond to the force (per unit of contact area) required to start the materials slipping away from each other. Such a test is inconceivable for graphene, Zhang says, because there’s no easy way to grab and pull individual sheets. Instead, he and his collaborators developed a shear measurement technique based on a so-called blister test.

To demonstrate the method, the researchers placed a single graphene sheet on top of a surface of silicon dioxide in which several micrometer-sized holes had been etched. The team was able to increase the air pressure inside the holes, causing the graphene “lid” to bulge upward. This bulging created an inward pull on the sheet, which was countered by the sticking force of the sheet to the surface. In order to study graphene-graphene stickiness, the researchers performed two sets of experiments: one with monolayer graphene and the other with bilayer graphene. In both cases, the bulge shape was measured with an atomic force microscope, and the amount of stretching in the carbon bonds was determined by recording the frequency shift in laser light scattered off the graphene surface (Raman spectroscopy technique).

The data showed that—for an equal bulge shape—the bilayer graphene exhibited a larger region of stretched atomic bonds beyond the dome than did the monolayer case. The explanation is that more carbon atoms get pulled inward by the bulge when they feel a weaker attachment to the layer below—as is the case for graphene on graphene. The team measured the change in the stretching area with increasing air pressure and determined a value of 40 kilopascals for the shear resistance between graphene layers with so-called AB-stacking, in which the honeycomb patterns are offset.

Zhang and his colleagues imagine that their new measurement technique could be used with other 2D materials. For example, graphene can be combined with boron nitride layers to create photodetectors. By applying strain to such devices, one can potentially tune their response to light, Zhang explains, so measuring the interlayer sticking force in these hybrid materials will be important.

The work “presents an elegant and novel technique to measure interface properties between 2D layers and substrates,” says mechanical engineering professor Horacio Espinosa from Northwestern University in Evanston, Illinois. He thinks it will give researchers new opportunities for the design of devices and materials. Material scientist Roland Bennewitz from the Leibniz Institute for New Materials in Saarbrücken, Germany, applauds the work for finally providing a quantitative basis for graphene’s superior lubrication properties. “Atomistic modeling can now be benchmarked against a reliable experimental result, and the surprising effectiveness of graphene in lubrication can be better understood,” Bennewitz says.

This research is published in Physical Review Letters.

–Michael Schirber
Michael Schirber is a Corresponding Editor for Physics based in Lyon, France.

Measuring Interlayer Shear Stress in Bilayer Graphene
Guorui Wang, Zhaohe Dai, Yanlei Wang, PingHeng Tan, Luqi Liu, Zhiping Xu, Yueguang Wei, Rui Huang, and Zhong Zhang
Phys. Rev. Lett. 119, 036101 (2017)
Published July 17, 2017​


Physics - Focus: Graphene Sliding on Graphene
 
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Chinese scientist develops world's most accurate 3rd-gen sequencer
(People's Daily Online) 16:11, July 19, 2017

FOREIGN201707191612000242927222949.jpg
He Jiankui shows a "gene book". (Southcn.com/Zhu Hongbo)

GenoCare, a new class of third-generation sequencing platform, designed and made by Chinese company Direct Genomics, is capable of directly measuring DNA and RNA sequencings at the single-molecule level without amplification, an article from biochemical sciences journal BioRxiv revealed on July 13, Science and Technology Daily reported.

Chinese and American scientists used the new GenoCare single molecule sequencing platform to resequence the E. coli genome. Results show that the accuracy of the new platform reached 99.71 percent, making it the most accurate sequencing platform in the world.

He Jiankui, born in 1980s, is the leading scientist of the research and development of the automated desktop sequencer GenoCare and a professor from Southern University of Science and Technology. At present, GenoCare is the only reliable third-generation sequencing platform with strong potential for clinical applications in the world, said He.

FOREIGN201707191612000370447329676.jpg
A researcher debugs a GenoCare sample third-generation single-molecule sequencer. (Nanfang Daily/Zhu Hongbo)

According to He, the first-generation DNA sequencing technology completed the first human genome mapping in 2001. The mapping process took three years, and cost billions of US dollars. The second-generation sequencing technology shortened the time to less than one week and shrunk the cost to $1,000. The latest technology is able to complete the work in 24 hours for only $100.

The core technology of the GenoCare platform is single-molecule fluorescence sequencing. The GenoCare detects single-molecule fluorescence by employing total internal reflection microscopy, together with sequencing-by-synthesis chemistry. The technology has greatly improved accuracy and lowered cost.

Yu Jun, a researcher at the Beijing Institute of Genomics, pointed out that the third-generation sequencer can be applied in both research and clinical fields, and has unlimited commercial prospects.
 
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Chinese scientist develops world's most accurate 3rd-gen sequencer
(People's Daily Online) 16:11, July 19, 2017

FOREIGN201707191612000242927222949.jpg
He Jiankui shows a "gene book". (Southcn.com/Zhu Hongbo)

GenoCare, a new class of third-generation sequencing platform, designed and made by Chinese company Direct Genomics, is capable of directly measuring DNA and RNA sequencings at the single-molecule level without amplification, an article from biochemical sciences journal BioRxiv revealed on July 13, Science and Technology Daily reported.

Chinese and American scientists used the new GenoCare single molecule sequencing platform to resequence the E. coli genome. Results show that the accuracy of the new platform reached 99.71 percent, making it the most accurate sequencing platform in the world.

He Jiankui, born in 1980s, is the leading scientist of the research and development of the automated desktop sequencer GenoCare and a professor from Southern University of Science and Technology. At present, GenoCare is the only reliable third-generation sequencing platform with strong potential for clinical applications in the world, said He.

FOREIGN201707191612000370447329676.jpg
A researcher debugs a GenoCare sample third-generation single-molecule sequencer. (Nanfang Daily/Zhu Hongbo)

According to He, the first-generation DNA sequencing technology completed the first human genome mapping in 2001. The mapping process took three years, and cost billions of US dollars. The second-generation sequencing technology shortened the time to less than one week and shrunk the cost to $1,000. The latest technology is able to complete the work in 24 hours for only $100.

The core technology of the GenoCare platform is single-molecule fluorescence sequencing. The GenoCare detects single-molecule fluorescence by employing total internal reflection microscopy, together with sequencing-by-synthesis chemistry. The technology has greatly improved accuracy and lowered cost.

Yu Jun, a researcher at the Beijing Institute of Genomics, pointed out that the third-generation sequencer can be applied in both research and clinical fields, and has unlimited commercial prospects.

Let me know when they actually start selling machines, and have some market share.

In terms of market, Illumina rules big!

I have heard such reports earlier as well, when BGI boasted of its own sequencers, both under production and development; but nothing came off it.

Also, the company is not even new. It is in operation since 2014.

It released GenoCare in 2015.

Can't see anyone really using its machines yet. It is Illumina's monopoly all the way.
 
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Chinese scientist develops world's most accurate 3rd-gen sequencer
(People's Daily Online) 16:11, July 19, 2017

FOREIGN201707191612000242927222949.jpg
He Jiankui shows a "gene book". (Southcn.com/Zhu Hongbo)

GenoCare, a new class of third-generation sequencing platform, designed and made by Chinese company Direct Genomics, is capable of directly measuring DNA and RNA sequencings at the single-molecule level without amplification, an article from biochemical sciences journal BioRxiv revealed on July 13, Science and Technology Daily reported.

Chinese and American scientists used the new GenoCare single molecule sequencing platform to resequence the E. coli genome. Results show that the accuracy of the new platform reached 99.71 percent, making it the most accurate sequencing platform in the world.

He Jiankui, born in 1980s, is the leading scientist of the research and development of the automated desktop sequencer GenoCare and a professor from Southern University of Science and Technology. At present, GenoCare is the only reliable third-generation sequencing platform with strong potential for clinical applications in the world, said He.

FOREIGN201707191612000370447329676.jpg
A researcher debugs a GenoCare sample third-generation single-molecule sequencer. (Nanfang Daily/Zhu Hongbo)

According to He, the first-generation DNA sequencing technology completed the first human genome mapping in 2001. The mapping process took three years, and cost billions of US dollars. The second-generation sequencing technology shortened the time to less than one week and shrunk the cost to $1,000. The latest technology is able to complete the work in 24 hours for only $100.

The core technology of the GenoCare platform is single-molecule fluorescence sequencing. The GenoCare detects single-molecule fluorescence by employing total internal reflection microscopy, together with sequencing-by-synthesis chemistry. The technology has greatly improved accuracy and lowered cost.

Yu Jun, a researcher at the Beijing Institute of Genomics, pointed out that the third-generation sequencer can be applied in both research and clinical fields, and has unlimited commercial prospects.

Great going! Keep it up! :yahoo::china:

images
 
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Let me know when they actually start selling machines, and have some market share.

In terms of market, Illumina rules big!

I have heard such reports earlier as well, when BGI boasted of its own sequencers, both under production and development; but nothing came off it.

Also, the company is not even new. It is in operation since 2014.

It released GenoCare in 2015.

Can't see anyone really using its machines yet. It is Illumina's monopoly all the way.
sour-grapes.jpg
 
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Let me know when they actually start selling machines, and have some market share.

In terms of market, Illumina rules big!

I have heard such reports earlier as well, when BGI boasted of its own sequencers, both under production and development; but nothing came off it.

Also, the company is not even new. It is in operation since 2014.

It released GenoCare in 2015.

Can't see anyone really using its machines yet. It is Illumina's monopoly all the way.
FYI, according to chinese media, the machine went commercial beginning of 2017. So far till July, approx. 700 units were sold.
 
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Discovery could lead to fewer side effects, better results for cancer patients
Published: July 19, 2017 • By Lisa Marshall

More than half of cancer patients undergo radiotherapy, in which high doses of radiation are aimed at diseased tissue to kill cancer cells. But due to a phenomenon known as radiation-induced bystander effect (RIBE), in which irradiated cells leak chemical signals that can travel some distance to damage unexposed healthy cells, many suffer side effects such as hair loss, fatigue and skin problems. This bystander effect may also make targeted cells resistant to radiation treatment, research suggests.

A CU Boulder study published today in the journal Nature sheds new light on the precise mechanism behind RIBE, identifying both a protein released by irradiated cells and the pathway it takes to influence healthy ones. Ultimately, researchers hope it could lead to a medication patients could take before radiation treatment.

“Inhibiting RIBE would allow doctors to kill two birds with one stone,” said lead author Ding Xue, a professor of molecular, cellular, and developmental biology at CU Boulder who collaborated with colleagues in China, Taiwan and Japan for the study. “We could minimize the bad effects of radiotherapy on healthy bystander cells, and at the same time, enhance cancer cell killing by radiotherapy.”

Nine years in the making, the study used a translucent, 1,000-cell worm called C. elegans as a model to study the bystander effect in action.

First, to be sure RIBE occurred in C. elegans, researchers exposed a population of the worms to radiation, then took a medium secreted by the C. elegans cells and bathed healthy C. elegans in it. The once-healthy animals began to show increased embryo deaths and other signs of RIBE.

The researchers then systematically treated the medium with agents designed to destroy proteins, DNA, and RNA, in order to determine which may be a key compound at play in RIBE. When the medium was treated with a protease, which breaks down proteins, C. elegans exposed to it did not show signs of RIBE.

3mcherrystylized.jpg
C. elegans under the microscope. The area in red has been exposed to radiation. Credit: Ding Xue

Once researchers discovered that the agent causing RIBE was a protein, they used a technique called mass spectrometry to establish which proteins present in the medium were at play. A protein called CPR-4—the C. elegans version of a human protease called cathepsin B—emerged as the prime candidate. Cathepsin B is known to be a biomarker in several types of cancer.

Then researchers studied which biological pathway enabled CPR-4 to signal changes in healthy cells that were never exposed to radiation. They identified a pathway mediated by the insulin-like growth factor receptor DAF-2.

To confirm these findings, they irradiated the heads of C. elegans who either lacked the gene that codes for CPR-4 or lacked the gene that codes for insulin-like growth factor receptor DAF-2. The bystander effect was blunted, with cells elsewhere in the body remaining healthy.

The study also found that a tumor suppressor gene called P53 may be at play in RIBE, prompting cells to produce more of the damaging CPR-4 protein when a cell is exposed to radiation.

“This is basically the first comprehensive study to identify the factor and mechanisms behind this radiation-induced bystander effect in animals,” said Xue, who hopes to work with other researchers in the future to identify other RIBE factors and mechanisms and help develop drugs that inhibit them.

“We are excited about these findings and believe they could have broad implications for patients as well as other important areas such as radiation protection and radiation safety,” he said.



Discovery could lead to fewer side effects, better results for cancer patients | CU Boulder Today | University of Colorado Boulder

Yu Peng, Man Zhang, Lingjun Zheng, Qian Liang, Hanzeng Li, Jeng-Ting Chen, Hongyan Guo, Sawako Yoshina, Yu-Zen Chen, Xiang Zhao, Xiaoqi Wu, Bin Liu, Shohei Mitani, Jau-Song Yu & Ding Xue. Cysteine protease cathepsin B mediates radiation-induced bystander effects. Nature (2017). DOI: 10.1038/nature23284
 
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Public Release: 19-Jul-2017
Dundee-China linkup uncovers secrets of our cellular 'energy sensor'
'Fructose-1,6-bisphosphate and aldolase mediate glucose sensing by AMPK'
University of Dundee

A scientific collaboration between researchers in Scotland and China has uncovered a new kind of `energy sensor' in our cells, changing our understanding of how the body monitors glucose levels and switches on the supply of alternative `fuels'.

It is thought the research, published in the journal Nature, could have particular implications for diabetes, in which the level of glucose in the blood is abnormally high.

The research focused on the activity of a protein called AMPK. Professor Grahame Hardie, of the School of Life Sciences at the University of Dundee, first identified AMPK in the 1990s as a key player in energy production in our bodies, and is one of the world's leading experts on how it works.

The AMPK enzyme is switched on when energy levels in the cell fall, and drives processes which stimulate energy production, while preventing energy-consuming processes.

Working with the group of Professor Shengcai Lin, at the University of Xiamen in China, they have now made a new breakthrough in understanding how this happens.

"Glucose is the primary fuel that cells `burn' to sustain life," said Professor Hardie. "My work in the 1990s showed that AMPK was switched on when the cell's energy state (carried by the chemicals ATP, ADP and AMP, which form a kind of "rechargeable battery") was running low.

"AMPK is important because it enables the body to start burning other `fuels'. For example, during exercise, when the demand for energy is dramatically increased in muscle, AMPK switches on the uptake and metabolism of glucose and fats to provide the required energy.

"It has been known for years that starving cells of glucose switches on AMPK, but everyone had assumed that this worked via the known ability of AMPK to sense changes in the cell's energy status.

"We have now shown that cells can actually sense glucose by a completely different mechanism, in which AMPK is recruited to structures called lysosomes. It is by doing this that cells can switch on pathways for metabolism of alternative fuels, such as fats, when glucose becomes scarce but before cellular energy declines."

Professor Hardie said more work would be needed to understand the full implications of this for human health. However, given the extremely prominent role of glucose in diabetes it is likely to be of significant value in understanding more about the disease.

AMPK is thought to be implicated in other conditions and diseases, including obesity and cancer.

Professor Hardie said the project had combined excellent science from both the UK and China. "Shengcai Lin made the initial exciting findings for this and it has been very rewarding to work with his group in China to sort out how it works," said Professor Hardie.

Professor Shengcai Lin said, "We, the Xiamen team, are very grateful for the fruitful collaboration with Professor Hardie, pioneer of AMPK. I believe the main implication of the work is not only the delineation of the sensing mechanism for glucose levels, but also its enabling us to think glucose is a status signal, the decline of which causes cells to switch off synthetic pathways by inhibiting pro-synthetic activities mediated by another master metabolic regulator called mTORC1."



Dundee-China linkup uncovers secrets of our cellular 'energy sensor' | EurekAlert! Science News

Chen-Song Zhang, Simon A. Hawley, Yue Zong, Mengqi Li, Zhichao Wang, Alexander Gray, Teng Ma, Jiwen Cui, Jin-Wei Feng, Mingjiang Zhu, Yu-Qing Wu, Terytty Yang Li, Zhiyun Ye, Shu-Yong Lin, Huiyong Yin, Hai-Long Piao, D. Grahame Hardie & Sheng-Cai Lin. Fructose-1,6-bisphosphate and aldolase mediate glucose sensing by AMPK, Nature (2017). DOI: 10.1038/nature23275
 
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Scientists Design Promising New Cathode for Sodium-based Batteries
July 20, 2017
By Stephanie Kossman

d9490617r-720px.jpg
Xiao-Qing Yang (left) and Enyuan Hu (center) of Brookhaven's Chemistry Department, pictured with beamline physicist Eli Stavitski (right) at the ISS beamline at NSLS-II.

Scientists have designed a new type of cathode that could make the mass production of sodium batteries more feasible. Batteries based on plentiful and low-cost sodium are of great interest to both scientists and industry as they could facilitate a more cost-efficient production process for grid-scale energy storage systems, consumer electronics and electric vehicles. The discovery was a collaborative effort between researchers at the Institute of Chemistry (IOC) of Chinese Academy of Sciences (CAS) and the U.S. Department of Energy’s (DOE) Brookhaven National Laboratory.

Lithium batteries are commonly found in consumer electronics such as smartphones and laptop computers, but in recent years, the electric vehicle industry also began using lithium batteries, significantly increasing the demand on existing lithium resources.

“Just last year, the price of lithium carbonate tripled, because the Chinese electric vehicle market started booming,” said Xiao-Qing Yang, a physicist at the Chemistry Division of Brookhaven Lab and the lead Brookhaven researcher on this study.

In addition, the development of new electrical grids that incorporate renewable energy sources like wind and solar is also driving the need for new battery chemistries. Because these energy sources are not always available, grid-scale energy storage systems are needed to store the excess energy produced when the sun is shining and the wind is blowing.

Scientists have been searching for new battery chemistries using materials that are more readily available than lithium. Sodium is one of the most desirable options for researchers because it exists nearly everywhere and is far less toxic to humans than lithium.

But sodium poses major challenges when incorporated into a traditional battery design. For example, a typical battery’s cathode is made up of metal and oxygen ions arranged in layers. When exposed to air, the metals in a sodium battery’s cathode can be oxidized, decreasing the performance of the battery or even rendering it completely inactive.

The researchers at IOC of CAS and Jiangxi Normal University sought to resolve this issue by substituting different types of metals in the cathode and increasing the space between these metals. Then, using the Inner-Shell Spectroscopy (ISS) beamline at Brookhaven’s National Synchrotron Light Source II (NSLS-II)—a DOE Office of Science User Facility—Brookhaven’s researchers compared the structures of battery materials with unsubstituted materials to these new battery materials with substitute metals.

“We use the beamline to determine how metals in the cathode material change oxidation states and how it correlates with the efficiency and lifetime of the battery’s structure,” says Eli Stavitski, a physicist at the ISS beamline.”

The ISS beamline was the first operational x-ray spectroscopy beamline at NSLS-II. Here, researchers shine an ultra-bright x-ray beam through materials to observe how light is absorbed or reemitted. These observations allow researchers to study the structure of different materials, including their chemical and electronic states.

The ISS beamline, which is specifically designed for high-speed experiments, allowed the researchers to measure real-time changes in the battery during the charge-discharge processes. Based on their observations made at the beamline, Brookhaven’s team discovered that oxidation was suppressed in the sodium batteries with substituted metals, indicating the newly designed sodium batteries were stable when exposed to air. This is a major step forward in enabling future mass production of sodium batteries.

The researchers say this study is the first of many that will use the ISS beamline at NSLS-II to advance the study of batteries.

This study was supported by several Chinese research organizations, including the National Key R&D Program of China. The work at Brookhaven National Laboratory was supported by DOE’s Office of Energy Efficiency and Renewable Energy, the Vehicle Technology Office under Advanced Battery Material Research (BMR). DOE’s Office of Science (BES) also supports operations at NSLS-II.


BNL Newsroom | Scientists Design Promising New Cathode for Sodium-based Batteries

Hu-Rong Yao et al. Designing Air-Stable O3-Type Cathode Materials by Combined Structure Modulation for Na-Ion Batteries, Journal of the American Chemical Society (2017). DOI: 10.1021/jacs.7b05176
 
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Chinese-led scientists found a new particle
By Gong Zhe (CNTV) 08:27, July 21, 2017

FOREIGN201707210827000012257740223.jpg

CGTN photo

Scientists at the Large Hadron Collider (LHC) in Switzerland have announced the discovery of a new particle.

Chinese scientists were involved with the research, as reported by Science and Technology Daily on Thursday.

"The newly-discovered particle is more proof of the Standard Model, another piece of the puzzle," said Gao Yuanning, leader of the Chinese team at LHC.

FOREIGN201707210827000264549206963.jpg

Report about the discovery on LHCb's website. /LHCb Screenshot

In particle physics, the Standard Model is a theory related to the basic particles that form the entire universe.

Although the theory is widely considered as solid by leading physicists worldwide, not all particles it predicts have actually been found.

Into the heart of the atom

The new particle has been called the "doubly charmed baryon" in an article published on the LHCb website.

It's widely taught in physics classes that the world is formed by atoms, and atoms are formed by protons, neutrons and electrons.

And protons and neutrons in turn are formed by a relatively modern concept, the quark.

As the article explains, the baryon consists of one up quark and two charm quarks, and its charge equals two.

It's rare that a particle has two charm quarks in it, Gao told reporters, adding that deeper research on the particle can help humans understand how everything is formed.

Chinese contribution

The team of LHCb has 1185 scientists from 16 different countries. The Chinese group has been working to find the baryon since 2010.

"Initially we wanted to find a baryon with two bottom quarks, but charm quarks are lighter and easier to produce. That's why we shifted our focus," Gao explained.

The charm quark was discovered by a Chinese-born scientist Samuel C. C. Ting, together with Burton Richter.

The two physicists received the Nobel Prize for Physics in 1976 for this discovery.
 
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Chinese-led scientists found a new particle
By Gong Zhe (CNTV) 08:27, July 21, 2017

FOREIGN201707210827000012257740223.jpg

CGTN photo

Scientists at the Large Hadron Collider (LHC) in Switzerland have announced the discovery of a new particle.

Chinese scientists were involved with the research, as reported by Science and Technology Daily on Thursday.

"The newly-discovered particle is more proof of the Standard Model, another piece of the puzzle," said Gao Yuanning, leader of the Chinese team at LHC.

FOREIGN201707210827000264549206963.jpg

Report about the discovery on LHCb's website. /LHCb Screenshot

In particle physics, the Standard Model is a theory related to the basic particles that form the entire universe.

Although the theory is widely considered as solid by leading physicists worldwide, not all particles it predicts have actually been found.

Into the heart of the atom

The new particle has been called the "doubly charmed baryon" in an article published on the LHCb website.

It's widely taught in physics classes that the world is formed by atoms, and atoms are formed by protons, neutrons and electrons.

And protons and neutrons in turn are formed by a relatively modern concept, the quark.

As the article explains, the baryon consists of one up quark and two charm quarks, and its charge equals two.

It's rare that a particle has two charm quarks in it, Gao told reporters, adding that deeper research on the particle can help humans understand how everything is formed.

Chinese contribution

The team of LHCb has 1185 scientists from 16 different countries. The Chinese group has been working to find the baryon since 2010.

"Initially we wanted to find a baryon with two bottom quarks, but charm quarks are lighter and easier to produce. That's why we shifted our focus," Gao explained.

The charm quark was discovered by a Chinese-born scientist Samuel C. C. Ting, together with Burton Richter.

The two physicists received the Nobel Prize for Physics in 1976 for this discovery.

While Chinese and US scientists have joined hands to achieve this great discovery:

JULY 20, 2017
An experiment proposed by Stanford theorists finds evidence for the Majorana fermion, a particle that’s its own antiparticle

In a discovery that concludes an 80-year quest, Stanford and University of California researchers found evidence of particles that are their own antiparticles. These 'Majorana fermions’ could one day help make quantum computers more robust. See video here.

BY GLENNDA CHUI

In 1928, physicist Paul Dirac made the stunning prediction that every fundamental particle in the universe has an antiparticle – its identical twin but with opposite charge. When particle and antiparticle met they would be annihilated, releasing a poof of energy. Sure enough, a few years later the first antimatter particle – the electron’s opposite, the positron – was discovered, and antimatter quickly became part of popular culture.

images



Shoucheng Zhang (Image credit: Courtesy SLAC National Accelerator Laboratory)

But in 1937, another brilliant physicist, Ettore Majorana, introduced a new twist: He predicted that in the class of particles known as fermions, which includes the proton, neutron, electron, neutrino and quark, there should be particles that are their own antiparticles.

Now a team including Stanford scientists says it has found the first firm evidence of such a Majorana fermion. It was discovered in a series of lab experiments on exotic materials at the University of California in collaboration with Stanford University. The team was led by UC-Irvine Associate Professor Jing Xia and UCLA Professor Kang Wang, and followed a plan proposed by Shoucheng Zhang, professor of physics at Stanford, and colleagues. The team reported the results July 20 in Science.

“Our team predicted exactly where to find the Majorana fermion and what to look for as its ‘smoking gun’ experimental signature,” said Zhang, a theoretical physicist and one of the senior authors of the research paper. “This discovery concludes one of the most intensive searches in fundamental physics, which spanned exactly 80 years.”

Although the search for the famous fermion seems more intellectual than practical, he added, it could have real-life implications for building robust quantum computers, although this is admittedly far in the future.

The particular type of Majorana fermion the research team observed is known as a “chiral” fermion because it moves along a one-dimensional path in just one direction. While the experiments that produced it were extremely difficult to conceive, set up and carry out, the signal they produced was clear and unambiguous, the researchers said.

“This research culminates a chase for many years to find chiral Majorana fermions. It will be a landmark in the field,” said Tom Devereaux, director of the Stanford Institute for Materials and Energy Sciences (SIMES) at SLAC National Accelerator Laboratory, where Zhang is a principal investigator.

“It does seem to be a really clean observation of something new,” said Frank Wilczek, a theoretical physicist and Nobel laureate at the Massachusetts Institute of Technology who was not involved in the study. “It’s not fundamentally surprising, because physicists have thought for a long time that Majorana fermions could arise out of the types of materials used in this experiment. But they put together several elements that had never been put together before, and engineering things so this new kind of quantum particle can be observed in a clean, robust way is a real milestone.”

Search for ‘quasiparticles’
Majorana’s prediction applied only to fermions that have no charge, like the neutron and neutrino. Scientists have since found an antiparticle for the neutron, but they have good reasons to believe that the neutrino could be its own antiparticle, and there are four experiments underway to find out – including EXO-200, the latest incarnation of the Enriched Xenon Observatory, in New Mexico. But these experiments are extraordinarily difficult and are not expected to produce an answer for about a decade.

About 10 years ago, scientists realized that Majorana fermions might also be created in experiments that explore the physics of materials – and the race was on to make that happen.

What they’ve been looking for are “quasiparticles” – particle-like excitations that arise out of the collective behavior of electrons in superconducting materials, which conduct electricity with 100 percent efficiency. The process that gives rise to these quasiparticles is akin to the way energy turns into short-lived “virtual” particles and back into energy again in the vacuum of space, according to Einstein’s famous equation E = mc2. While quasiparticles are not like the particles found in nature, they would nonetheless be considered real Majorana fermions.

Over the past five years, scientists have had some success with this approach, reporting that they had seen promising Majorana fermion signatures in experiments involving superconducting nanowires.

But in those cases the quasiparticles were “bound” – pinned to one particular place, rather than propagating in space and time – and it was hard to tell if other effects were contributing to the signals researchers saw, Zhang said.

A ‘smoking gun’
In the latest experiments at UCLA and UC-Irvine, the team stacked thin films of two quantum materials – a superconductor and a magnetic topological insulator – and sent an electrical current through them, all inside a chilled vacuum chamber.

The top film was a superconductor. The bottom one was a topological insulator, which conducts current only along its surface or edges but not through its middle. Putting them together created a superconducting topological insulator, where electrons zip along two edges of the material’s surface without resistance, like cars on a superhighway.

It was Zhang’s idea to tweak the topological insulator by adding a small amount of magnetic material to it. This made the electrons flow one way along one edge of the surface and the opposite way along the opposite edge.

Then the researchers swept a magnet over the stack. This made the flow of electrons slow, stop and switch direction. These changes were not smooth, but took place in abrupt steps, like identical stairs in a staircase.

At certain points in this cycle, Majorana quasiparticles emerged, arising in pairs out of the superconducting layer and traveling along the edges of the topological insulator just as the electrons did. One member of each pair was deflected out of the path, allowing the researchers to easily measure the flow of the individual quasiparticles that kept forging ahead. Like the electrons, they slowed, stopped and changed direction – but in steps exactly half as high as the ones the electrons took.

These half-steps were the smoking gun evidence the researchers had been looking for.

The results of these experiments are not likely to have any effect on efforts to determine if the neutrino is its own antiparticle, said Stanford physics Professor Giorgio Gratta, who played a major role in designing and planning EXO-200.

“The quasiparticles they observed are essentially excitations in a material that behave like Majorana particles,” Gratta said. “But they are not elementary particles and they are made in a very artificial way in a very specially prepared material. It’s very unlikely that they occur out in the universe, although who are we to say? On the other hand, neutrinos are everywhere, and if they are found to be Majorana particles we would show that nature not only has made this kind of particles possible but, in fact, has literally filled the universe with them.”

He added, “Where it gets more interesting is that analogies in physics have proved very powerful. And even if they are very different beasts, different processes, maybe we can use one to understand the other. Maybe we will discover something that is interesting for us, too.”

Angel particle
Far in the future, Zhang said, Majorana fermions could be used to construct robust quantum computers that aren’t thrown off by environmental noise, which has been a big obstacle to their development. Since each Majorana is essentially half a subatomic particle, a single qubit of information could be stored in two widely separated Majorana fermions, decreasing the chance that something could perturb them both at once and make them lose the information they carry.

For now, he suggests a name for the chiral Majorana fermion his team discovered: the “angel particle,” in reference to the best-selling 2000 thriller “Angels and Demons” in which a secret brotherhood plots to blow up the Vatican with a time bomb whose explosive power comes from matter-antimatter annihilation. Unlike in the book, he noted, in the quantum world of the Majorana fermion there are only angels – no demons.

The materials used for this study were produced at UCLA by a team led by postdoctoral researcher Qing Lin He and graduate student Lei Pan. Scientists from the KACST Center for Excellence in Green Nanotechnology in Saudia Arabia, UC-Davis, Florida State University, Fudan University in Shanghai and Shanghai Tech University also contributed to the experiment. Major funding came from the SHINES Center, an Energy Frontier Research Center at UC-Riverside funded by the U.S. Department of Energy Office of Science. Zhang’s work was funded by the DOE Office of Science through SIMES.

http://news.stanford.edu/2017/07/20/evidence-particle-antiparticle/





The 29 June 2017 edition of Nature magazine is out.
The paper is in there :yahoo:,

Observation of three-component fermions in the topological semimetal molybdenum phosphide
Nature
546,
627–631
(29 June 2017)

doi:10.1038/nature22390
Received
22 November 2016
Accepted
19 April 2017
Published online
19 June 2017

More of the above publication in XinhuaNews

Chinese scientists discover new type of fermion: Nature
Source: Xinhua| 2017-06-20 19:47:45|Editor: Mengjie



BEIJING, June 20 (Xinhua) -- Chinese scientists have discovered a new type of fermion that opens up a way of exploring the interplay between unconventional fermions in condensed-matter systems.

The research team was led by scientists with the Institute of Physics of the Chinese Academy of Sciences (CAS), whose findings were published in the online version of the academic journal "Nature Communications" on Monday.

In quantum field theory, Lorentz invariance leads to three types of fermion -- Dirac, Weyl and Majorana. The existence of Dirac and Weyl fermions in condensed-matter systems has been confirmed experimentally, and that of Majorana fermions is supported by various experiments.

In condensed-matter systems, however, fermions in crystals are "constrained by the symmetries of the crystal space groups rather than by Lorentz invariance," giving rise to the possibility of finding other types of fermionic excitation that have no counterparts in high-energy physics.

The CAS scientists used a technique to observe the distribution of electrons, called angle-resolved photoemission spectroscopy, which demonstrated the existence of a "triply degenerate point in the electronic structure of crystalline molybdenum phosphide," -- a brand new discovery in field of fermion research.

They have also observed pairs of Weyl points in the bulk electronic structure of the crystal that coexist with the three-component fermions.

So do we have a team in China which also discovered the "Angel's Particle"?

images
 
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China strengthens national clinical research centers
Source: Xinhua| 2017-07-22 22:17:40|Editor: Liangyu



BEIJING, July 22 (Xinhua) -- China will strengthen the establishment of national clinical research centers, according to the Ministry of Science and Technology.

A total of 32 national clinical research centers, involving 11 disease categories such as cardiovascular disease, malignant tumor and respiratory system, were given licenses at a conference on advancing clinical research held by national authorities in Beijing on Saturday.

A development plan, a guideline and an assessment plan on national clinical research centers were released at the conference.

According to Wang Zhigang, vice minister of science and technology, national clinical research centers should take on the main responsibility in linking clinical medicine with life sciences and biotechnology research, and applying clinical research into practice.

National clinical research centers will be located at 30 top hospitals and more than 2,100 medical institutions.
 
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Public Release: 21-Jul-2017
Special focus on formation control of unmanned systems

Science China Press

This shows trajectories of the leader and followers.
Credit: ©Science China Press


An Unmanned System refers to the autonomous agent possessing the capability of basic sensing, communication, data processing and actuation. Formation control of unmanned systems has become one of the most active topics in the past decade. The objective is to drive multiple agents to achieve particular tasks cooperatively. Usually, appropriate reference positions or distances are required to be maintained for the agents to avoid collisions. Based on the cooperative scheme, more complex tasks that a single agent cannot fulfilled can be accomplished by a collection of agents. Up until now, quite a lot of applications of formation control for unmanned systems are witnessed in the areas of logistics, agriculture, military systems, etc., including surveillance, exploration, rescuing, aerial photography and 3D sensing.

2017 No.7 issue of SCIENCE CHINA Information Sciences published a special issue focus on formation control of unmanned Systems. This special focus is expected to present readers with some recent significant achievements on formation control of unmanned systems. Seven excellent papers have been accepted in this special focus to cover up-to-date advances in theoretical design and applications of this research topic.

--> Special focus on formation control of unmanned systems | EurekAlert! Science News

A survey on recent progress in control of swarm systems
Bing ZHU, Lihua XIE, Duo HAN, Xiangyu MENG & Rodney TEO
Sci China Inf Sci, 2017, 60(7): 070201

Formation control with disturbance rejection for a class of Lipschitz nonlinear systems
Chunyan WANG, Zongyu ZUO, Qinghai GONG & Zhengtao DING
Sci China Inf Sci, 2017, 60(7): 070202

Saturated coordinated control of multiple underactuated unmanned surface vehicles over a closed curve
Lu LIU, Dan WANG, Zhouhua PENG & Hugh H.T. LIU
Sci China Inf Sci, 2017, 60(7): 070203

Fault-tolerant cooperative control for multiple UAVs based on sliding mode techniques
Peng LI, Xiang YU, Xiaoyan PENG, Zhiqiang ZHENG & Youmin ZHANG
Sci China Inf Sci, 2017, 60(7): 070204

Simultaneous attack of a stationary target using multiple missiles: a consensus-based approach
Jialing ZHOU, Jianying YANG & Zhongkui LI
Sci China Inf Sci, 2017, 60(7): 070205

Leader-follower formation of vehicles with velocity constraints and local coordinate frames
Xiao YU & Lu LIU
Sci China Inf Sci, 2017, 60(7): 070206

Tight formation control of multiple unmanned aerial vehicles through an adaptive control method
Yin WANG & Daobo WANG
Sci China Inf Sci, 2017, 60(7): 070207
 
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