China HIV vaccine on phase 3 trial

[PakistaniLion111]

The implication is Chinese HIV vaccine phase 1 and 2 trial likely be quite successful. Imagine the shock to the western big pharma and politicians if China comes out first with HIV vaccine.

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We made our design different from other groups in the world. We do not use natural immunogen. We redesigned the HIV immunogen based on the first lentiviral vaccine. The first lentiviral vaccine is for a horse virus that has been invented by Chinese scientists in the 70s. We worked with Professor Shen, who invented the first lentiviral vaccine, and studied his mechanism, and we found a structure change on the envelope of this protein between the vaccine's strain and wild type strain. Based on that, we redesigned the envelope of the HIV vaccine. This is one innovation.

Second innovation: We thought maybe not only the antibody, we still need the T cell immune response. We designed what we called heterologous prime-boost approach by priming the human or animal with DNA vaccine, and boost with another viral vector, which is a poxvirus. Again, different from many other groups that use non-replicating dead vector, we are using replication-competent live vector. So what we chose is the Chinese smallpox vaccine which has been used in the last century to eradicate smallpox in China. We use this vector by traditional skin scarification. In this combination, we can stimulate good antibody response and T cell response.

We have concluded three Phase-1 trials. We concluded the first Phase-2 trial of this type of replicating competent viral vector HIV vaccine. We are currently doing a second Phase-2 trial with additional vector boost. We are moving this vaccine project next year into Phase-3 trial — the last one to test if this vaccine works or not.

How close is China to developing an HIV vaccine?

Success can only be reached by using all the tools to fight against HIV. Vaccine is just one of the tools in the box.

news.cgtn.com

That's cool man!

 

[denel]

Well the vaccine will prevent HIV infections, but I'm sorry that it won't cure your condition. Don't get mad at us.

No it does not; that is pure silliness at its naivity.

HIV virus is extremely illusive; when you think you have a way to mimic it; it is one of the most adaptable viruses known to mankind highly mutative. That has been the problem all along.

We had many trials but as soon as most ambitious ones got into phase 3 trials; complete flat on the face. There are many different types of HIV not just one, this is what this news fails to recognise; each type has its own challenges.

HIV subtype diversity worldwide : Current Opinion in HIV and AIDS

onary process has resulted in several HIV subtypes that are heterogeneously globally distributed. Recent findings Subtype A remains the most prevalent strain in parts of East Africa, Russia and former Soviet Union countries; subtype B in Europe, Americas and Oceania; subtype C in Southern...

journals.lww.com

Just read this medical journal paper you will understand; the task of understanding this virus remains very illusive.

Purpose of review
To provide a summary of the current data on the global HIV subtype diversity and distribution by region. HIV is one of the most genetically diverse pathogens due to its high-mutation and recombination rates, large population size and rapid replication rate. This rapid evolutionary process has resulted in several HIV subtypes that are heterogeneously globally distributed.

Recent findings
Subtype A remains the most prevalent strain in parts of East Africa, Russia and former Soviet Union countries; subtype B in Europe, Americas and Oceania; subtype C in Southern Africa and India; CRF01_AE in Asia and CRF02_AG in Western Africa. Recent studies based on near full-length genome sequencing highlighted the growing importance of recombinant variants and subtype C viruses.

Summary
The dynamic change in HIV subtype distribution presents future challenges for diagnosis, treatment and vaccine design and development. An increase in recombinant viruses suggests that coinfection and superinfection by divergent HIV strains has become more common necessitating continuous surveillance to keep track of the viral diversity. Cheaper near full-length genome sequencing approaches are critical in improving HIV subtype estimations. However, missing subtype data and low sequence sampling levels are still a challenge in some geographical regions.

 

[Song Hong]

HIV vaccine not too elusive at current time.

Western hvtn 702 HIV vaccine was found to be 30% effective in thailand but 0% effective in South Africa. Blacks mate too much and engage in too risky behavior.

Failed phase 3.

Now watch Chinese vaccine in action.

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The trial had enrolled more than 5,400 participants at 14 sites in South Africa to test a vaccine based on a regimen that was found to be around 31% effective during a vaccine trial in Thailand, according to results released in 2009.

For the first time, researchers say infusions of antibodies can prevent HIV infection

Researchers demonstrated for the first time that infusions of antibodies can prevent HIV infection. According to clinical trial results presented at the HIV Research for Prevention virtual meeting, infusions of a broadly neutralizing antibody (bNAb) called VRC01 were effective at preventing...

www.healio.com

Key HIV vaccine trial in South Africa ends because of poor results

Decision described as a ‘significant setback’ by International Aids Society

www.theguardian.com

HIV vaccine suffers setback

Discover the world’s best science and medicine | Nature.com

www.nature.com

 

[ZeEa5KPul]

It's really amazing. China Derangement Syndrome is so severe that its sufferers would rather HIV remain untreatable than China be the one to end it.