China HIV vaccine on phase 3 trial

[Song Hong]

The implication is Chinese HIV vaccine phase 1 and 2 trial likely be quite successful. Imagine the shock to the western big pharma and politicians if China comes out first with HIV vaccine.

*************

We made our design different from other groups in the world. We do not use natural immunogen. We redesigned the HIV immunogen based on the first lentiviral vaccine. The first lentiviral vaccine is for a horse virus that has been invented by Chinese scientists in the 70s. We worked with Professor Shen, who invented the first lentiviral vaccine, and studied his mechanism, and we found a structure change on the envelope of this protein between the vaccine's strain and wild type strain. Based on that, we redesigned the envelope of the HIV vaccine. This is one innovation.

Second innovation: We thought maybe not only the antibody, we still need the T cell immune response. We designed what we called heterologous prime-boost approach by priming the human or animal with DNA vaccine, and boost with another viral vector, which is a poxvirus. Again, different from many other groups that use non-replicating dead vector, we are using replication-competent live vector. So what we chose is the Chinese smallpox vaccine which has been used in the last century to eradicate smallpox in China. We use this vector by traditional skin scarification. In this combination, we can stimulate good antibody response and T cell response.

We have concluded three Phase-1 trials. We concluded the first Phase-2 trial of this type of replicating competent viral vector HIV vaccine. We are currently doing a second Phase-2 trial with additional vector boost. We are moving this vaccine project next year into Phase-3 trial — the last one to test if this vaccine works or not.

How close is China to developing an HIV vaccine?

Success can only be reached by using all the tools to fight against HIV. Vaccine is just one of the tools in the box.

news.cgtn.com

 

[Michael Corleone]

Wow that’s one way to make a vaccine. Revolutionary.
but I wonder if big western pharmas will release their vaccines earlier. China will have to undercut them and be transparent will efficacy results. Good job to the scientist involved

maybe people will ditch condoms thinking they can always get a vaccine? Who knowd

 

[fallstuff]

This is great, not that I will need one.

 

[charene514]

Could potentially be a hoax like the covid vaccine

Let's wait and see.

 

[GumNaam]

gonna see a lotta homosexuals & sex workers flocking to China over medical tourism...

 

[TruthSeeker]

Novel Vaccine Approach for HIV Prevention Shows Promising Results in First-in-Human Trial

Investigators believe that an effective HIV vaccine would need to produce broadly neutralizing antibodies that would work on different strains of the virus.

www.pharmacytimes.com

Novel Vaccine Approach for HIV Prevention Shows Promising Results in First-in-Human Trial
2021-02-11 21:31:00
Aislinn Antrim, Assistant Editor
A phase 1 trial of a novel approach for HIV vaccination successfully stimulated production of rare immune cells needed to start the process of generating antibodies against the virus. Notably, the targeted response was detected in 97% of participants who received the vaccine, according to a press release.

“This study demonstrates proof of principle for a new vaccine concept for HIV, a concept that could be applied to other pathogens, as well,” said William Schief, PhD, whose laboratory developed the vaccine, in a press release. “With our many collaborators on the study team, we showed that vaccines can be designed to stimulate rare immune cells with specific properties, and this targeted stimulation can be very efficient in humans. We believe this approach will be key to making an HIV vaccine and possibly important for making vaccines against other pathogens.”

HIV affects more than 38 million people globally and is known to be one of the most difficult viruses to target with a vaccine. One of the major challenges is because the virus constantly evolves into different strains to evade the immune system.

Investigators have worked for decades to create a vaccine that would stimulate the immune system to create rare but powerful antibodies called broadly neutralizing antibodies (bnAbs). According to the press release, bnAbs are specialized blood proteins that could attach to HIV spikes and disable them via important yet difficult-to-access regions that don’t vary much from strain to strain.

“We and others postulated many years ago that in order to induce bnAbs, you must start the process by triggering the right B cells—cells that have special properties giving them potential to develop into bnAb-secreting cells,” Schief explained in the press release. “In this trial, the targeted cells were only about 1 in a million of all naïve B cells. To get the right antibody response, we first need to prime the right B cells. The data from this trial affirms the ability of the vaccine immunogen to do this.”

The strategy of targeting naïve B cells with specific properties is called germline-targeting, because these young B cells display germline genes. Investigators believe the approach could also be applied to vaccines for other challenging pathogens, such as influenza, dengue, Zika, hepatitis C virus, and malaria.

The clinical trial, IAVI G001, enrolled 48 healthy adult volunteers who received either a placebo or 2 doses of the vaccine compound along with an adjuvant developed by GSK. According to the investigators, the novel design, the clinical trial, and the molecular B cell analyses provide a roadmap for further progress in an HIV vaccine.

“This is a tremendous achievement for vaccine science as a whole,” said Dennis Burton, PhD, scientific director of the IAVI Neutralizing Antibody Center and director of the NIH Consortium for HIV/AIDS Vaccine Development, in a press release. “This clinical trial has shown that we can drive immune responses in predictable ways to make new and better vaccines, and not just for HIV. We believe this type of vaccine engineering can be applied more broadly, bringing about a new day in vaccinology.”

REFERENCE
First-in-human clinical trial confirms novel HIV vaccine approach developed by IAVI and Scripps Research [news release]. Scripps Research; February 3, 2021. https://www.scripps.edu/news-and-events/press-room/2021/20210203-hiv-vaccine.html. Accessed February 9, 2021.

 

[Globenim]

US state propaganda mouthpieces have to work overtime to smear and drown all the good news coming out of China with their lies

 

[RealNapster]

maybe people will ditch condoms thinking they can always get a vaccine? Who knowd

Condom's not just prevent STD's but also help those in family planning who do not want to use medication for the reason.

 

[Michael Corleone]

Condom's not just prevent STD's but also help those in family planning who do not want to use medication for the reason.

Yeah sure. But statistically fewer people use condoms as a contraceptive vs other methods

 

[RealNapster]

Yeah sure. But statistically fewer people use condoms as a contraceptive vs other methods

But other methods have other side effects. Like medication for the same purpose makes body weak and fat..

 

[Michael Corleone]

But other methods have other side effects. Like medication for the same purpose makes body weak and fat..

Condoms have side effects too allergy
None are 100% reliable. Best bet is to use a couple contraceptives together to avoid pregnancy

 

[Daniel808]

Could potentially be a hoax like the covid vaccine

Let's wait and see.

What hoax dude, Like building a toilet in your country?

Chinese Covid-19 Vaccine Update per 2021 February, 14

https://twitter.com/x/status/1360858472770805763

 

[denel]

The implication is Chinese HIV vaccine phase 1 and 2 trial likely be quite successful. Imagine the shock to the western big pharma and politicians if China comes out first with HIV vaccine.

*************

We made our design different from other groups in the world. We do not use natural immunogen. We redesigned the HIV immunogen based on the first lentiviral vaccine. The first lentiviral vaccine is for a horse virus that has been invented by Chinese scientists in the 70s. We worked with Professor Shen, who invented the first lentiviral vaccine, and studied his mechanism, and we found a structure change on the envelope of this protein between the vaccine's strain and wild type strain. Based on that, we redesigned the envelope of the HIV vaccine. This is one innovation.

Second innovation: We thought maybe not only the antibody, we still need the T cell immune response. We designed what we called heterologous prime-boost approach by priming the human or animal with DNA vaccine, and boost with another viral vector, which is a poxvirus. Again, different from many other groups that use non-replicating dead vector, we are using replication-competent live vector. So what we chose is the Chinese smallpox vaccine which has been used in the last century to eradicate smallpox in China. We use this vector by traditional skin scarification. In this combination, we can stimulate good antibody response and T cell response.

We have concluded three Phase-1 trials. We concluded the first Phase-2 trial of this type of replicating competent viral vector HIV vaccine. We are currently doing a second Phase-2 trial with additional vector boost. We are moving this vaccine project next year into Phase-3 trial — the last one to test if this vaccine works or not.

How close is China to developing an HIV vaccine?

Success can only be reached by using all the tools to fight against HIV. Vaccine is just one of the tools in the box.

news.cgtn.com

Another crap post; reality is HIV remains a very difficult virus to combat with a vaccine. Every stage 3 trial has failed with every vaccine tried. another glorious propaganda post to please the PLA trolls to take the offensive.

Dont push this rubbish propaganda - give real peer paper research papers please.

 

[Daniel808]

Another anti-china butthurters crying like a baby

They will show the research result after they have Phase III done, in the next year

 

[S10]

Another crap post; reality is HIV remains a very difficult virus to combat with a vaccine. Every stage 3 trial has failed with every vaccine tried. another glorious propaganda post to please the PLA trolls to take the offensive.

Dont push this rubbish propaganda - give real peer paper research papers please.

Well the vaccine will prevent HIV infections, but I'm sorry that it won't cure your condition. Don't get mad at us.