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The U.S. Opioid Epidemic

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The U.S. Opioid Epidemic
Opioid addiction in the United States has reached epidemic proportions, threatening not only public health but economic output and national security.

Backgrounder by Claire Felter

Last updated January 17, 2019

Introduction
The United States is grappling with one of its worst-ever drug crises. More than nine hundred people a week die from opioid-related overdoses, and some experts say the death toll may not peak for years. Meanwhile, millions more Americans suffer from opioid addiction.

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The crisis has reached such a scale that, beyond the risks it poses to public health, it is becoming a drag on the economy and a threat to national security. Analysts say the problem started with the overprescription of legal pain medications, such as oxycodone, but note that it has intensified in recent years with an influx of cheap heroin and synthetic opioids, such as fentanyl, supplied by foreign-based drug cartels.

In recent years, the U.S. government has ramped up efforts to cut both the foreign and domestic supply of opioids, limiting the number of prescriptions in the United States while providing counternarcotics assistance to countries including Mexico and China. Meanwhile, federal and state officials have attempted to reduce demand by focusing less on punishing drug users and more on treating them. Other countries where opioid use has also spiked, such as Canada and Australia, are experimenting with different policies.

What drugs are contributing to the crisis?
Opioids, a class of drugs derived from the opium poppy plant, can be divided into two broad categories: legally manufactured medications and illicit narcotics.

Opioid medications, including oxycodone, hydrocodone, and morphine, are commonly prescribed to treat pain, while methadone is primarily used in addiction treatment centers to reduce patients’ dependence on opioids. Opioids gained popularity among doctors in the 1990s for treating patients who had undergone surgery or cancer treatment, but in the last fifteen years physicians increasingly prescribed them for chronic conditions, such as back or joint pain, despite concerns about their safety and effectiveness.

We didn’t develop an opioid epidemic until there was a huge surplus of opioids, which started with pharmaceutical drugs.
Bridget G. Brennan, New York Special Narcotics Prosecutor


Heroin has for decades been the most commonly used illegal opioid. Over the last several years the heroin supply in the United States has soared, and the drug can now be obtained for a third of the price it was in the early 1990s.

People in the last few years have increasingly turned to synthetic opioids, such as fentanyl, which is especially lethal. Some law enforcement officials have labeled the drug “manufactured death” because it is cheaper and up to fifty times more potent than heroin. Fentanyl-related deaths are largely caused by the drug’s illegal use, though it can also be prescribed as a painkiller. The Centers for Disease Control and Prevention (CDC) notes that heroin and fentanyl are most often used in combination with other drugs, such as cocaine, or alcohol, which increases the risk of overdose.

What is the scale of the epidemic?
Overdose deaths involving opioids have increased sixfold since 1999. In 2017, the most recent year for which data is available, opioid overdoses killed more than forty-seven thousand people, or more than six times the number of U.S. military servicemembers killed in the post-9/11 wars in Iraq and Afghanistan. The opioid mortality rate that year contributed to the third straight yearly decline in life expectancy [PDF] in the United States. (The country last experienced such a decline in the 1960s.)

Many health experts attribute the rising death toll to what they say has been years of overprescribing by physicians. Doctors began prescribing more opioids amid a growing concern that pain was going undertreated, and also because pharmaceutical companies began marketing them more aggressively while claiming they posed little risk. Health-care providers have reported feeling pressure to prescribe opioid medications rather than alternatives, such as physical therapy or acupuncture, because patients request them and other treatments are often more costly or less accessible.

Opioid-related deaths have grown in lockstep with the volume of opioids prescribed. A spike in the use of illegal opioids in the United States followed the rise in prescriptions, as many users turn to heroin and other illegal drugs once they can no longer obtain enough of their prescribed drug to keep pace with what may be a developing addiction. “We didn’t develop an opioid epidemic until there was a huge surplus of opioids, which started with pharmaceutical drugs distributed legally,” says New York Special Narcotics Prosecutor Bridget G. Brennan.

What are the demographics of the opioid crisis?
The vast majority of those who overdose on opioids are non-Hispanic white Americans, who make up close to 80 percent of the annual total. Non-Hispanic black Americans and Hispanic Americans account for about 11 and 8 percent of cases, respectively. Economists Anne Case and Angus Deaton have argued that the rise in what they call “deaths of despair,” which include drug overdoses, particularly among white Americans without college degrees, are primarily the result of wages stagnating over the last four decades and a decline in available jobs.

U.S. military veterans, many of whom suffer from chronic pain as a result of their service, account for a disproportionately high number of opioid-related deaths. Veterans are twice as likely as the general population to die from an opioid overdose, according to a study commissioned by the National Institutes of Health.

What have been the socioeconomic consequences?
The opioid epidemic is having devastating consequences on public health, causing high rates of hepatitis C, HIV, and other diseases, mainly due to shared syringes. Meanwhile, mothers may pass an opioid dependency on to their children if they use while pregnant. Incidences of neonatal abstinence syndrome almost quadrupled from 2000 to 2012. The opioid crisis may also have contributed to an uptick in the number of children in foster care.

Opioids have also begun to take a toll on the economy. Testifying before the U.S. Senate in 2017, Janet Yellen, then chair of the Federal Reserve, linked the opioid epidemic to declining labor-force participation among “prime-age workers.” Princeton University economist Alan Krueger says it could account for 20 percent of the decline in participation among men and 25 percent among women from 1999 to 2015. As one example of this, a boiler manufacturing company in Ohio, the state with the second-largest number of opioid-related deaths, reported that at least a quarter of its job applicants failed drug tests. The firm says the workforce shortage costs it roughly $800,000 in orders a year, which end up going to foreign competitors.

Where are the heroin and fentanyl coming from?
The opioid crisis has also become a national security concern. Most of the heroin coming into the United States is cultivated on poppy farms in Mexico, with eight cartels controlling production and operating distribution hubs in major U.S. cities. Mexican cartels, which the U.S. Drug Enforcement Administration (DEA) has called the “greatest criminal drug threat to the United States,” typically smuggle narcotics across the U.S. southwest border in passenger vehicles or tractor trailers. Large quantities of heroin are also produced in South American countries, particularly Colombia, and trafficked to the United States by air and sea. Although most of the world’s heroin comes from Afghanistan, only a small portion of the U.S. supply is produced there.

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Most fentanyl coming to the United States is produced in China, U.S. officials say, and commonly transited through Mexico. Chinese authorities “have struggled to adequately regulate thousands of chemical and pharmaceutical facilities operating legally and illegally in the country,” says a 2017 report [PDF] issued by a congressionally mandated commission.

What has the United States done to restrict foreign narcotics?
Over the past decade, the United States has provided Mexico with nearly $3 billion in counternarcotics aid, including for police and judicial reforms, in a program known as the Merida Initiative. The initiative, which U.S. officials say led to the capture of some top cartel leaders, including Joaquin “El Chapo” Guzman, has continued under the administration of President Donald J. Trump, though funding has declined in recent years. Through a similar partnership with Colombia, the United States has provided almost $10 billion since 2000; it effectively drew to a close following the end to civil conflict there in 2016.

The DEA, the leading U.S. agency involved in counternarcotics, has also coordinated efforts with China, which has designated more than one hundred synthetic drugs as controlled substances. China banned production of four fentanyl variations in 2017, although some analysts fear these moves will only spur clandestine labs to create new alternatives. In a 2018 meeting with President Trump, Chinese President Xi Jinping pledged to restrict all fentanyl-like substances, a move Trump hailed as a “game changer,” though Beijing has yet to implement it.

Recent U.S. administrations have also increased the number of border patrol agents to approximately twenty thousand. Heroin seizures and trafficking arrests more than doubled [PDF] between 2007 and 2017, many near the southwestern border.

In his first weeks in office, President Trump issued executive orders directing the construction of a southern border wall and additional increases to the number of border patrol agents. Some analysts say a wall would do little to curb drug flows, however, as most illicit drugs are smuggled through ports of entry.

What are some efforts to restrict domestic supply?
Federal agencies, state governments, insurance providers, and physicians all influence the supply of opioid medications.

Federal regulators have introduced new limits on opioid prescriptions, reducing the total nationwide by 25 percent from their 2010 peak to 2017, according to the CDC. The agency issued guidelines in March 2016 advising physicians not to prescribe opioids as a first-line therapy. The DEA reduced production quotas for pharmaceutical manufacturers by at least 25 percent that year for opioids categorized as Schedule II drugs, or those that are currently accepted for medical use but carry high risk of misuse; these include oxycodone, fentanyl, and morphine. The agency has since proposed additional cuts, in line with a call by Trump to reduce the number of filled prescriptions by one-third in three years.

Reporting by the Washington Post and 60 Minutes, however, found that a law passed in 2016 after heavy lobbying by pharmaceutical companies has effectively stripped the DEA of its ability to freeze suspicious shipments of narcotics. A December 2018 congressional report on painkiller shipments to West Virginia found that lack of oversight by the DEA fueled the black market and worsened the epidemic in the state.

In 2018, the Justice Department ramped up efforts to prosecute those involved in overprescribing and trafficking. In April it partnered with nearly all state attorneys general to share opioid prescription information in order to investigate drug crimes, and in its largest-ever move to crack down on health-care fraud, it brought charges against more than 150 doctors, nurses, pharmacists, and others for their alleged roles in distributing opioids.

Additionally, lawmakers in more than fifteen states have passed or considered legislation limiting opioid prescriptions since the start of 2016. States including Mississippi, New Jersey, Ohio, and Oklahoma, as well as dozens of cities, are suing pharmaceutical companies, alleging they overstated the benefits of prescription opioids and concealed the risks.

What is the United States doing to reduce demand?
Previous federal antidrug campaigns relied on incarceration to deter drug use and trafficking. This approach has been widely criticized for failing to keep people from cycling in and out of prison and for disproportionately targeting African Americans. In recent years, federal and state officials have shifted toward prevention and treatment.

President Barack Obama reduced prison sentences for hundreds of nonviolent drug offenders during his tenure. However, he failed to secure legislation that would have eliminated mandatory minimum sentences for federal drug crimes. His administration also established hundreds of new drug courts, which proponents say are an effective alternative to incarceration. Drug courts, the first of which was launched in 1989, under the George H.W. Bush administration, provide nonviolent offenders an alternative to the criminal-justice system that involves monitoring and rehabilitation services rather than prison time.

In recent years, federal and state officials have shifted toward prevention and treatment.


In 2016, President Obama signed legislation authorizing more than $1 billion in funding, largely in the form of state grants, to expand opioid treatment and prevention programs, as well as make the drug naloxone, which can counteract opioid overdoses in emergencies, more readily available.

Some city and local governments have launched what are known as harm-reduction programs, which focus on limiting virus transmission and overdoses through the promotion of safer drug use. Critics of such programs argue that decriminalization would lead to higher rates of drug use.

In October 2017, President Trump declared the epidemic a public health emergency, freeing up some federal grant funds for states to direct toward the crisis and loosening restrictions on access to treatment. Meanwhile, a presidential commission recommended other policies [PDF] to combat the crisis. A year later, Trump signed into law the Support for Patients and Communities Act, bipartisan legislation aimed at further expanding access to addiction treatment and increasing research on alternative pain medications, among other things. However, some observers say it does not provide enough sustained funding to curb the crisis.

Many working on the issue believe the government should direct more resources toward educating the public about risks. “I don’t think we’ve done enough in terms of informing people about the dangers—about the nexus between opioid medication and heroin and illicit drugs,” says Brennan. “If we did the kind of information campaign that was so successful with tobacco, I think we could see terrific results.”

How are other countries dealing with opioid addiction?
The Netherlands. The Netherlands permits the sale and use of small amounts of cannabis to steer users away from so-called hard drugs [PDF], such as cocaine and heroin, and has implemented harm-reduction policies. In the 1990s the country began offering heroin at no cost, and the rate of high-risk or so-called problem use was halved from 2002 to some fourteen thousand in 2012, according to the European Monitoring Centre for Drugs and Drug Addiction, which estimates the decline has since continued. Proponents of decriminalization point to the Netherlands for evidence that these policies work, though critics claim they have not curbed organized crime.

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Canada. Amid a growing opioid crisis of its own, Canada has authorized the opening of supervised consumption sites and partnered with China to curb fentanyl flows into the country. British Columbia and Alberta, two of Canada’s most populous provinces, declared a public health emergency and crisis, respectively, boosting funding for addiction treatment and increasing access to naloxone. Opioid-related deaths in the country are still on the rise, however, with the death toll reaching nearly four thousand in 2017, a 33 percent increase from a year earlier. In mid-2018, the health ministry announced it would seek to restrict most marketing and advertising for opioids.

Australia. Heroin use in Australia declined following an abrupt shortage of the drug in 2000, but the country has seen a sharp increase in the use of prescription opioids, now the cause of more than two-thirds of opioid-related deaths there. In 2012, the health ministry announced it would launch a nationwide electronic system already being used in Tasmania to monitor opioid prescriptions, but it has not yet been rolled out. In January 2018, the government enacted a ban on over-the-counter painkillers containing codeine.

https://www.cfr.org/backgrounder/us-opioid-epidemic
 
Opioid Crisis Fast Facts
CNN Library

Updated 0157 GMT (0957 HKT) January 17, 2019
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Photos: Opioids: Addictive painkillers

Experts say the United States is in the throes of an opioid epidemic, as more than two million Americans have become dependent on or abused prescription pain pills and street drugs.
Opioids are drugs formulated to replicate the pain-educing properties of opium. They include both legal painkillers like morphine, oxycodone, or hydrocodone prescribed by doctors for acute or chronic pain, as well as illegal drugs like heroin or illicitly made fentanyl. The word "opioid" is derived from the word "opium."
During 2017, there were more than 72,000 overdose deaths in the United States, including 49,068 that involved an opioid, according to a provisional CDC count. More than 130 people died every day from opioid-related drug overdoses in 2016 and 2017, according to the US Department of Health & Human Services (HHS).
The number of opioid prescriptions dispensed by doctors steadily increased from 112 million prescriptions in 1992 to a peak of 282 million in 2012, according to the market research firm IMS Health. The number of prescriptions dispensed has since declined, falling to 236 million in 2016. The number dropped 10.2% in 2017 from 2016, according to IQVIA (formerly IMS Health)
.
Common opioids:
Opioids bind to receptors in the brain and spinal cord, disrupting pain signals. They also activate the reward areas of the brain by releasing the hormone dopamine, creating a feeling of euphoria or a "high."

Opioids such as morphine and codeine are naturally derived from opium poppy plants more commonly grown in Asia, Central America and South America. Heroin is an illegal drug synthesized from morphine.

Hydrocodone and oxycodone are semi-synthetic opioids, manufactured in labs with natural and synthetic ingredients. Between 2007 and 2016, the most widely prescribed opioid was hydrocodone (Vicodin). In 2016, 6.2 billion hydrocodone pills were distributed nationwide. The second most prevalent opioid was oxycodone (Percocet). In 2016, 5 billion oxycodone tablets were distributed in the United States.

The International Narcotics Control Board reported that in 2015, Americans represented about 99.7% of the world's hydrocodone consumption.

Fentanyl is a fully synthetic opioid, originally developed as a powerful anesthetic for surgery. It is also administered to alleviate severe pain associated with terminal illnesses like cancer. The drug is up to 100 times more powerful than morphine. Just a small dose can be deadly. Illicitly produced fentanyl has been a driving factor in the number of overdose deaths in recent years.

Methadone is another fully synthetic opioid. It is commonly dispensed to recovering heroin addicts to relieve the symptoms of withdrawal.

Addiction:

Opioid use disorder is the clinical term for opioid addiction or abuse.

People who become dependent on opioids may experience withdrawal symptoms when they stop taking the pills. Dependence is often coupled with tolerance, meaning that opioid users need to take increasingly larger doses of the medication for the same effect.

About 11.4 million Americans misused prescription pain medicine in 2016 and 2017, according to the HHS. About 886,000 people used heroin.

People who become dependent on pain pills may switch to heroin because it is less expensive than prescription drugs. The National Institute on Drug Abuse estimates that half of young people who inject heroin turned to the street drug after abusing prescription painkillers, also that three in four new heroin users start out using prescription drugs.

The number of overdose deaths related to heroin increased 533% between 2002 and 2016, from an estimated 2,089 in 2002 to 13,219 in 2016.

A drug called naloxone, available as an injection or a nasal spray, is used as a treatment for overdoses. It blocks or reverses the effects of opioids and is often carried by first responders.

More data on overdose deaths

Regulation and funding:

In 2013, the cost of medical care and substance abuse treatment for opioid addiction and overdose was an estimated $78.5 billion, according to a report in the journal Medical Care.

The 21st Century Cures Act, passed in 2016, allocated $1 billion over two years in opioid crisis grants to states, providing funding for expanded treatment and prevention programs. In April 2017, Health and Human Services Secretary Tom Price announced the distribution of the first round of $485 million in grants to all 50 states and US territories.

In August 2017, Attorney General Jeff Sessions announced the launch of an Opioid Fraud and Abuse Detection Unit within the Department of Justice. The unit's mission is to prosecute individuals who commit opioid-related health care fraud. The DOJ is also appointing US attorneys who will specialize in opioid health care fraud cases as part of a three-year pilot program in 12 jurisdictions nationwide.
State legislatures are also introducing measures to regulate pain clinics and limit the quantity of opioids that doctors can dispense.

Emergence of a crisis:

1861-1865 - During the Civil War, medics use morphine as a battlefield anesthetic. Many soldiers become dependent on morphine after the war.

1898 - Heroin is first produced commercially by the Bayer Company. At the time, heroin is believed to be less habit-forming than morphine, so it is dispensed to individuals who are addicted to morphine.

1914 - Congress passes the Harrison Narcotics Act, which requires that doctors write prescriptions for narcotic drugs like opioids and cocaine. Importers, manufacturers and distributors of narcotics must register with the Treasury Department and pay taxes on products

1924 - The Anti-Heroin Act bans the production and sale of heroin in the United States.

1970 - The Controlled Substances Act becomes law. It creates groupings (or schedules) of drugs based on the potential for abuse. Heroin is a Schedule I drug while morphine, fentanyl, oxycodone (Percocet, OxyContin) and methadone are Schedule II. Vicodin - a hydrocodone-acetaminophen combination - was originally a Schedule III medication but wasn't recategorized as a Schedule II drug until October 2014.

January 10, 1980 - A letter titled "Addiction Rare in Patients Treated with Narcotics" is published in the New England Journal of Medicine. It was not a study and looked at incidences of addiction in a very specific population of hospitalized patients who were closely monitored. However, it would become widely cited as proof that narcotics were a safe treatment for chronic pain.

1995 - OxyContin, a long acting version of oxycodone, which slowly releases the drug over 12 hours, is introduced and aggressively marketed as a safer pain pill by manufacturer, Purdue Pharma.

May 10, 2007 - The federal government brings criminal charges against Purdue Pharma for misleadingly advertising OxyContin as safer and less addictive than other opioids. The company and three executives are charged with "misleading and defrauding physicians and consumers." Purdue Pharma and the executives plead guilty, agreeing to pay a $634.5 million in criminal and civil fines. The three executives plead guilty on criminal misdemeanor charges and are later sentenced to probation.

2010 - FDA approves an "abuse-deterrent" formulation of OxyContin, to help curb abuse. However, people still find ways to abuse it.

May 20, 2015 - The DEA announces that it has arrested 280 people, including 22 doctors and pharmacists, after a 15-month sting operation centered on health care providers who dispense large amounts of opioids. The sting, dubbed Operation Pilluted, is the largest prescription drug bust in the history of the DEA.

March 18, 2016 - The CDC publishes guidelines for prescribing opioids for patients with chronic pain. Recommendations include prescribing over-the-counter pain relievers like acetaminophen and ibuprofen in lieu of opioids. Doctors are encouraged to promote exercise and behavioral treatments to help patients cope with pain.

March 29, 2017 - President Donald Trump signs an executive order calling for the establishment of the President's Commission on Combating Drug Addiction and the Opioid Crisis. New Jersey Governor Chris Christie is selected as the chairman of the group, with Trump's son-in-law, Jared Kushner, as an adviser.

July 31, 2017 - After a delay, the White House panel examining the nation's opioid epidemic releases its interim report, asking rump to declare a national public health emergency to combat the ongoing crisis

September 22, 2017 - The pharmacy chain CVS announces that it will implement new restrictions on filling prescriptions for opioids, dispensing a limited seven-day supply to patients who are new to pain therapy.

November 1, 2017 - The opioid commission releases its final report. Its 56 recommendations include a proposal to establish nationwide drug courts that would place opioid addicts in treatment facilities rather than prison.

February 9, 2018 - A budget agreement signed by Trump authorizes $6 billion for opioid programs, with $3 billion allocated for 2018 and $3 billion allocated for 2019.

February 27, 2018 - Attorney General Jeff Sessions announces a new opioid initiative: the Prescription Interdiction & Litigation (PIL) Task Force. The mission of the task force is to support local jurisdictions that have filed lawsuits against prescription drugmakers and distributors.

March 19, 2018 - The Trump administration outlines an initiative to stop opioid abuse. The three areas of concentration are law enforcement and interdiction; prevention and education via an ad campaign; and job-seeking assistance for individuals fighting addiction.

April 9, 2018 - The US surgeon general issues an advisory recommending that Americans carry the opioid overdose-reversing drug, naloxone. A surgeon general advisory is a rarely used tool to convey an urgent message. The last advisory issued by the surgeon general, more than a decade ago, focused on drinking during pregnancy.

May 1, 2018 - The Journal of the American Medical Association publishes a study that finds synthetic opioids like fentanyl caused about 46% of opioid deaths in 2016. That's a three-fold increase compared with 2010, when synthetic opioids were involved in about 14% of opioid overdose deaths. It's the first time that synthetic opioids surpassed prescription opioids and heroin as the primary cause of overdose fatalities.

June 7, 2018 - White House announces a new multimillion dollar public awareness advertising campaign to combat opioid addiction. The first four ads of the campaign are all based on true stories illustrating the extreme lengths young adults have gone to get a hold of the powerful drugs.

October 24, 2018 - Trump signs sweeping legislation into law that includes provisions aimed at promoting research to find new drugs for pain management that will not be addictive. It also expands access to treatment for substance use disorders for Medicaid patients.

December 12, 2018 - According to the latest numbers from the CDC's National Center for Health Statistics, fentanyl is now the most commonly used drug involved in drug overdoses. The rate of drug overdoses involving the synthetic opioid skyrocketed by about 113% each year from 2013 through 2016.

January 14, 2019 - The National Safety Council finds that, for the first time on record, the odds of dying from an opioid overdose in the United States are now greater than those of dying in a vehicle crash.

January 15, 2019 - A court filing in a Massachusetts lawsuit reveals that members of the Sackler family, who own Purdue Pharma, misled doctors and patients about the dangers of OxyContin.

https://edition.cnn.com/2017/09/18/health/opioid-crisis-fast-facts/index.html
 
We need to invent even more addictive substances for these snowflakes to consume as they realize their country is no longer the center of the world!
 
There are countries that ban woman to wear open cloth and man to drink alcohol, but producers of drugs.

Double standard in morality.
 
Life came full circle, Uncle Trump beg Xi to stop legally sell opioid to the US, none can imagine a white man president beg China ban selling of opioid, fentanyl to the US.
 
  • According to the National Survey on Drug Use and Health (NSDUH), 21.5 million American adults (aged 12 and older) battled a substance use disorder in 2014.
  • Almost 80 percent of individuals suffering from a substance use disorder in 2014 struggled with an alcohol use disorder, NSDUH
  • Over 7 million Americans in 2014 battled a drug use disorder, per NSDUH.
  • One out of every eight people who suffered from a drug use disorder in 2014, according to NSUDH, struggled with both alcohol and drug use disorders simultaneously.
  • The Substance Abuse and Mental Health Services Administration (SAMHSA) publishes that in 2014, almost 8 million American adults battled both a mental health disorder and a substance use disorder, or co-occurring disorders.
  • Drug abuse and addiction cost American society close to $200 billion in healthcare, criminal justice, legal, and lost workplace production/participation costs in 2007, the Office on National Drug Control Policy (ONDCP) reports.
  • The World Health Organization (WHO) estimates the global burden of disease related to drug and alcohol issues to be 5.4 percent worldwide.

To put things in perspective USA has a population of 320 million
 
Nice, opioid epidemic must spread to britain and other white countries. :cheers:
 

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