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New signs suggest coronavirus was in California far earlier than anyone knew

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New signs suggest coronavirus was in California far earlier than anyone knew
By PAIGE ST. JOHNSTAFF WRITER
APRIL 11, 20205 AM
Source:https://www.latimes.com/california/...rus-deaths-signs-of-earlier-spread-california

SACRAMENTO — A man found dead in his house in early March. A woman who fell sick in mid-February and later died.

These early COVID-19 deaths in the San Francisco Bay Area suggest that the novel coronavirus had established itself in the community long before health officials started looking for it. The lag time has had dire consequences, allowing the virus to spread unchecked before social distancing rules went into effect.

The virus was freewheeling in our community and probably has been here for quite some time,” Dr. Jeff Smith, a physician who is the chief executive of Santa Clara County government, told county leaders in a recent briefing.

How long? A study out of Stanford suggests a dramatic viral surge in February.

But Smith on Friday said data collected by the federal Centers for Disease Control and Prevention, local health departments and others suggest it was “a lot longer than we first believed” — most likely since “back in December.

This wasn’t recognized because we were having a severe flu season,” Smith said in an interview. “Symptoms are very much like the flu. If you got a mild case of COVID, you didn’t really notice. You didn’t even go to the doctor. The doctor maybe didn’t even do it because they presumed it was the flu.

Just as New York has strong ties to travelers from Europe, who are believed to have brought the coronavirus there from Italy, the Bay Area is a natural hub for those traveling to and from China. Santa Clara County had its first two cases of COVID-19 almost a week before federal approval of emergency testing for the disease Feb. 4. Both were in travelers returning from Wuhan, China, where the virus was rampant.

In January and most of February, there was little, if any, community testing in California.

The CDC provided testing materials to only some health departments, with restrictions that confined testing and thus the tracking of the novel coronavirus to those who were sick or exposed to someone already known to have COVID-19. The federal agency’s focus was on cruise ships, with Princess Cruises’ Diamond Princess carrying the largest known cluster of COVID-19 cases outside of China. The first passenger tested positive for COVID-19 five days after the ship’s Jan. 20 departure from Japan. Eventually, 712 passengers and crew tested positive, and nine of them died.

COVID-19 did not reappear in the Bay Area until Feb. 27, when doctors finally decided to test a hospitalized woman who had been ill for weeks. She became the region’s first case of community-spread coronavirus.

But from there, almost every positive test pointed toward local spread. “When public health [officials] tried to track down the start of the disease … we weren’t able to find, specifically, a contact,” Smith told county supervisors. “That means the virus is in the community already — not, as was suspected by the CDC, as only in China and being spread from contact with China.”

Researchers still unsure how long the virus lurked are now turning to blood banks and other repositories to see if lingering antibodies can show them what was missed. A study funded by the National Institutes of Health is looking for virus antibodies in samples from blood banks in Los Angeles, San Francisco and four other cities across the country.

Santa Clara County’s first community-spread case also became its first announced COVID-19 death.

Azar Ahrabi, 68, died March 9, the second COVID-19 fatality in California, five days after the first. For the first few weeks, the urban county that sits at the heart of Silicon Valley, home to Stanford University and tech giants Apple and Google, led California in coronavirus deaths.

Health investigators said they could find no source of Ahrabi’s infection. Her family members said she stayed mostly at home, taking care of her mother. She seldom drove, and she walked to a local grocery store to shop. But she and her mother lived in a Santa Clara apartment complex in a neighborhood with a high density of international residents.

Relatives said she showed signs of illness in mid-February. For more than a week, they gave only a passing thought that her fever and sudden fatigue might be tied to the horrifying news out of China.

Ahrabi’s son, Amir, said that when his mother checked into a medical clinic Feb. 20 and was diagnosed with a nonspecific pneumonia, she was prescribed antibiotics and sent home. The next day, her doctor admitted her to the intensive care unit.

Amir said he asked that she be tested for COVID-19, and doctors told him the county health department would not approve the test. She met none of the qualifying criteria.

New studies out of Stanford University and the CDC, taken together, suggest that the novel coronavirus spread quickly through the Bay Area.

Stanford’s virology lab, looking retroactively at some 2,800 patient samples collected since January, did not find the first COVID-19 cases until late February — from two patients who were tested Feb. 21 and Feb. 23. Neither of those patients, the researchers note in a letter published by the Journal of the American Medical Assn., would have met existing criteria for COVID-19 testing.

The California Department of Public Health and the CDC did not begin community surveillance for COVID-19 in Santa Clara County until March 5. Samples were collected from 226 coughing, feverish patients who visited four urgent care centers; 1 in 4 turned out to have the flu. The state tested samples from a subset of 79 non-flu patients. Nine of them had COVID-19.

The result suggested that 8% of people walking into the urgent care centers carried the novel coronavirus, an infection rate that mirrored the 5% infection rate at a Los Angeles medical center, the CDC said in a report published Friday.
 
No wonder the infection is so wide in US. It's impossible it's been spreading so fast in just a month time.
 
Than USA and not China ruined the world economy and human lifes. A biological TERROR ATTACK by USA, then. They should prepare of coming reparations ;)
 
20200412134036_859962.jpg
 
Slowly, but surely, more reliable scientific data will point the source of the virus to the US.
 
Slowly, but surely, more reliable scientific data will point the source of the virus to the US.

"Just as New York has strong ties to travelers from Europe, who are believed to have brought the coronavirus there from Italy, the Bay Area is a natural hub for those traveling to and from China. Santa Clara County had its first two cases of COVID-19 almost a week before federal approval of emergency testing for the disease Feb. 4. Both were in travelers returning from Wuhan, China, where the virus was rampant."
 
Before you start to jump the gun. Some facts.
The original research paper for A,B,C Type is here : https://www.pnas.org/content/early/2020/04/07/2004999117

The geographical origins have been depicted in this diagram by the authors:
F1.medium.gif

"
Phylogenetic network of 160 SARS-CoV-2 genomes. Node A is the root cluster obtained with the bat (R. affinis) coronavirus isolate BatCoVRaTG13 from Yunnan Province. Circle areas are proportional to the number of taxa, and each notch on the links represents a mutated nucleotide position. The sequence range under consideration is 56 to 29,797, with nucleotide position (np) numbering according to the Wuhan 1 reference sequence (8). The median-joining network algorithm (2) and the Steiner algorithm (9) were used, both implemented in the software package Network5011CS (https://www.fluxus-engineering.com/), with the parameter epsilon set to zero, generating this network containing 288 most-parsimonious trees of length 229 mutations. The reticulations are mainly caused by recurrent mutations at np11083. The 161 taxa (160 human viruses and one bat virus) yield 101 distinct genomic sequences. The phylogenetic diagram is available for detailed scrutiny in A0 poster format (SI Appendix, Fig. S5) and in the free Network download files.
"

Further more here is what the researchers say about 'A' subgroup:

"""
We use this bat virus as an outgroup, resulting in the root of the network being placed in a cluster of lineages which we have labeled “A.” Overall, the network, as expected in an ongoing outbreak, shows ancestral viral genomes existing alongside their newly mutated daughter genomes.

There are two subclusters of A which are distinguished by the synonymous mutation T29095C. In the T-allele subcluster, four Chinese individuals (from the southern coastal Chinese province of Guangdong) carry the ancestral genome, while three Japanese and two American patients differ from it by a number of mutations. These American patients are reported to have had a history of residence in the presumed source of the outbreak in Wuhan. The C-allele subcluster sports relatively long mutational branches and includes five individuals from Wuhan, two of which are represented in the ancestral node, and eight other East Asians from China and adjacent countries. It is noteworthy that nearly half (15/33) of the types in this subcluster, however, are found outside East Asia, mainly in the United States and Australia.
"""

In a nutshell, the virus group A was found to be closest related to a Coronavirus in bats which is endemic to China (Sample from Yunan province) hence it puts to rest all the theory that this infection started from USA. It didn't.

Also, two subgroups of group A have one cluster which was Chinese and another cluster which had americans who then migrated to USA after having a history to residence in Wuhan.

The virus originated from China. Simple.

Slowly, but surely, more reliable scientific data will point the source of the virus to the US.
Quite wrong. Read my post above and dont fall to dishonest Chinese propaganda.
 
“The virus was freewheeling in our community and probably has been here for quite some time,” Dr. Jeff Smith, a physician who is the chief executive of Santa Clara County government, told county leaders in a recent briefing.

Just as New York has strong ties to travelers from Europe, who are believed to have brought the coronavirus there from Italy, the Bay Area is a natural hub for those traveling to and from China. Santa Clara County had its first two cases of COVID-19 almost a week before federal approval of emergency testing for the disease Feb. 4. Both were in travelers returning from Wuhan, China, where the virus was rampant.

It just means it was rampant in China earlier than we thought.

Than USA and not China ruined the world economy and human lifes. A biological TERROR ATTACK by USA, then. They should prepare of coming reparations ;)

That's not what the article says. It says it was rampant in China well before we canceled airline flights.
 
It just means it was rampant in China earlier than we thought.



That's not what the article says. It says it was rampant in China well before we canceled airline flights.

You know the meaning of irony?

China is looking for a whipping boy. And who is better predestined than US. Who is, of course, able to do such things.
 
It just means it was rampant in China earlier than we thought.
In China, it was circulating since September. In Wuhan, it mutated into something worse and exploded. Interestingly, the earlier type (so called A) is able to spread in non-East-Asians much more easily, explaining why it is so preventable in USA and Asia as compared to in China.

This should put all the "theories" of it being a US weapon to rest. Why will US design a weapon which infects its citizen and preferably its citizens? Only after mutating into B type it spreaded in China.
 
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