Israeli Development: A molecule that neutralizes deadly viruses that pass from animals to humans
Virus trap: Scientists have been able to engineer a molecule that attracts dangerous viruses, preventing infection with deadly diseases that lead to death. The possibility of developing human treatment on its basis is now being considered
The Scientific Magic Journey, Weizmann Institute
Posted: 22.01.20, 11:16 PM
Some of the deadliest viruses that can be transmitted from animals to humans are part of the Erna virus family. Two of the viruses, known as Junín and Machupo, have previously infected humans in South America who have come in contact with infected rodents. Like Ebola, these viruses can cause hemorrhagic fever leading to rapid death, and the only treatments available for these diseases are only dangerous, complex, and highly effective. Recently, scientists at the Weizmann Institute of Science and their partners have researched a molecule that neutralizes the viruses Hunin and Machopo, and other viruses from the same family, which could be a cure for those viruses. Their findings are currently being published in the scientific journal Nature Communications.
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How, at all, do the Arena viruses cross the line and move from rodents or other animals to humans? In a previous study in Dr. Ron Diskin's laboratory from the Department of Structural Biology, researchers compared viruses that were able to pass on humans and other non-human-infected viruses. Researchers found that non-human viruses carry proteins that are not suitable for binding to the receptor. Used as a viral entry point for human cells, but surprisingly, even in the dangerous viruses, proteins are not perfectly suited to the human receptor, yet their only partial adaptation is sufficient to penetrate.
Partial matching gave rise to the idea of developing a seduction molecule: to use the rodent cell receptors that fitted as a "glove next" to the viral "entry proteins" to entice and trap the viruses and keep them away from human cells. "Previous attempts to develop such 'sticky' traps - that is, molecules designed to attract viral proteins - were based on human receptors," explains Dr. Diskin. "The fact that these receptors were identical to the receptors they were supposed to compete prevented them from showing real competition." However, a rodent-based receptor molecule, researchers believe, could be a significant competition for human receptors.
The active part of the molecule "Arnsept" (rainbow filaments) binds to the receptor of the chupu virus (gray)
The active part of the molecule "Arnsept" (rainbow filaments) binds to the receptor of the chupu virus (in gray) (Weizmann Institute)
To put this to the test, Dr. Hadas Cohen-Honey of Dr. Diskin's research group removed the rodent receptor tip from a "surgical" receptor, assembled it on an antibody - and created a new molecule named "Arneft". The group began to test this molecule on various tests; First, against "pseudo-viruses" - engineered virus-like carriers that carry the viral entry proteins, but pose no danger. Already at this stage, in collaboration with Dr. Vered Pedler-Krawani's research group at Tel Aviv University, the researchers saw that not only was the graft molecule tightly linked to the mock viruses, it also mobilized the immune system to attack the viral invasion.
The following research steps were conducted at laboratories at the University of Texas, Galveston, the United States, and at the Pasteur Institute, Lyon, France, where high-risk dangerous disease trials can be conducted. In these labs, Harnspet first dealt with the attacks of the viruses Hunin and Machopo. In these experiments, too, the researchers observed that Harnspet binds strongly to the viruses before they are sufficient to bind to human receptors and that the immune response is activated.
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Because Encrypt is based on a common point of entry for all viruses in the Erna family, and not unique features of each virus (as is the case with vaccines or antibodies, for example), it is effective against all viruses in this family that transmit to humans from animals and use the same receptor. "It may even be effective against the same undiscovered virus of the same family," Dr. Diskin says. Moreover, all signs indicate that arsenate is non-toxic and can withstand high temperatures, so it can be sent to the hot areas where these diseases are a danger. It is also believed that the idea of creating mammalian honey trap traps could be implemented in a variety of other diseases that transmit to humans from animals.
Imaging of measles virus
Viral mimic: Immaculate molecule recruits immune system (Photo: Shutterstock)
Knowledge, the Weizmann Institute of Science's intellectual property commercialization arm, which promotes industrial and medical applications based on the inventions of the institute's scientists, has patented the method, and is currently exploring options for developing harnesses as human health care.
Dr. Aliza Bornstein-Katz from the Weizmann Institute of Science also participated in the study; Dr. Ron Amon of Tel Aviv University; Crystal Agnes, Robert Cross and Professor Thomas Geisbert of the University of Texas, and Dr. Mathieu Matteo and Professor Sylvain Baise of the Pasteur Institute
https://www.ynet.co.il/health/article/S1AKOYHZ8 translted by google
Virus trap: Scientists have been able to engineer a molecule that attracts dangerous viruses, preventing infection with deadly diseases that lead to death. The possibility of developing human treatment on its basis is now being considered
The Scientific Magic Journey, Weizmann Institute
Posted: 22.01.20, 11:16 PM
Some of the deadliest viruses that can be transmitted from animals to humans are part of the Erna virus family. Two of the viruses, known as Junín and Machupo, have previously infected humans in South America who have come in contact with infected rodents. Like Ebola, these viruses can cause hemorrhagic fever leading to rapid death, and the only treatments available for these diseases are only dangerous, complex, and highly effective. Recently, scientists at the Weizmann Institute of Science and their partners have researched a molecule that neutralizes the viruses Hunin and Machopo, and other viruses from the same family, which could be a cure for those viruses. Their findings are currently being published in the scientific journal Nature Communications.
Read more:
The "Mysterious Chinese Virus" epidemic: That's how the outbreak is prepared
An unpleasant vacation: The infections that are hidden in your hotel room
Toilet dryers: Bacteria distributors - researchers say
Expect: "Deadly Chinese Virus" - Fear of a World Plague Outbreak
Play Video
(Reuters)
at TaboolaPromoted Links.
Hot and indulgent: The 49 best soups in restaurants in the country
+ ynet
Alon Gal: "Give me 21 minutes, and I'll show you how to bring home another paycheck without working thin ...
today's news
Nothing out of the ordinary, the hybrid crossover in a new and groundbreaking version, enter
iCAR
How, at all, do the Arena viruses cross the line and move from rodents or other animals to humans? In a previous study in Dr. Ron Diskin's laboratory from the Department of Structural Biology, researchers compared viruses that were able to pass on humans and other non-human-infected viruses. Researchers found that non-human viruses carry proteins that are not suitable for binding to the receptor. Used as a viral entry point for human cells, but surprisingly, even in the dangerous viruses, proteins are not perfectly suited to the human receptor, yet their only partial adaptation is sufficient to penetrate.
Partial matching gave rise to the idea of developing a seduction molecule: to use the rodent cell receptors that fitted as a "glove next" to the viral "entry proteins" to entice and trap the viruses and keep them away from human cells. "Previous attempts to develop such 'sticky' traps - that is, molecules designed to attract viral proteins - were based on human receptors," explains Dr. Diskin. "The fact that these receptors were identical to the receptors they were supposed to compete prevented them from showing real competition." However, a rodent-based receptor molecule, researchers believe, could be a significant competition for human receptors.
The active part of the molecule "Arnsept" (rainbow filaments) binds to the receptor of the chupu virus (gray)
The active part of the molecule "Arnsept" (rainbow filaments) binds to the receptor of the chupu virus (in gray) (Weizmann Institute)
To put this to the test, Dr. Hadas Cohen-Honey of Dr. Diskin's research group removed the rodent receptor tip from a "surgical" receptor, assembled it on an antibody - and created a new molecule named "Arneft". The group began to test this molecule on various tests; First, against "pseudo-viruses" - engineered virus-like carriers that carry the viral entry proteins, but pose no danger. Already at this stage, in collaboration with Dr. Vered Pedler-Krawani's research group at Tel Aviv University, the researchers saw that not only was the graft molecule tightly linked to the mock viruses, it also mobilized the immune system to attack the viral invasion.
The following research steps were conducted at laboratories at the University of Texas, Galveston, the United States, and at the Pasteur Institute, Lyon, France, where high-risk dangerous disease trials can be conducted. In these labs, Harnspet first dealt with the attacks of the viruses Hunin and Machopo. In these experiments, too, the researchers observed that Harnspet binds strongly to the viruses before they are sufficient to bind to human receptors and that the immune response is activated.
Ad by IDX
Because Encrypt is based on a common point of entry for all viruses in the Erna family, and not unique features of each virus (as is the case with vaccines or antibodies, for example), it is effective against all viruses in this family that transmit to humans from animals and use the same receptor. "It may even be effective against the same undiscovered virus of the same family," Dr. Diskin says. Moreover, all signs indicate that arsenate is non-toxic and can withstand high temperatures, so it can be sent to the hot areas where these diseases are a danger. It is also believed that the idea of creating mammalian honey trap traps could be implemented in a variety of other diseases that transmit to humans from animals.
Imaging of measles virus
Viral mimic: Immaculate molecule recruits immune system (Photo: Shutterstock)
Knowledge, the Weizmann Institute of Science's intellectual property commercialization arm, which promotes industrial and medical applications based on the inventions of the institute's scientists, has patented the method, and is currently exploring options for developing harnesses as human health care.
Dr. Aliza Bornstein-Katz from the Weizmann Institute of Science also participated in the study; Dr. Ron Amon of Tel Aviv University; Crystal Agnes, Robert Cross and Professor Thomas Geisbert of the University of Texas, and Dr. Mathieu Matteo and Professor Sylvain Baise of the Pasteur Institute
https://www.ynet.co.il/health/article/S1AKOYHZ8 translted by google
