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Google Celebrates Pakistan born Nobel-Prize Winning Biochemist Har Gobind Khorana

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Google Celebrates Pakistan born and raised Nobel-Prize Winning Biochemist Har Gobind Khorana

Har Gobind Khorana Google Doodle

Rohan Dahotre / Google
By JENNIFER CALFAS
Updated: January 9, 2018 5:27 PM ET
Indian-American biochemist Har Gobind Khorana, known for his construction of the first synthetic gene and renowned research in nucleic acids and proteins, is being honored with a Google Doodle Tuesday, on what would have been Khorana’s 96th birthday.

Khorana’s work uncovered how a DNA’s genetic code determines protein synthesis — which dictates how a cell functions. That discovery earned khorana, along with two colleagues, the 1968 Nobel Prize in Physiology or Medicine “for their interpretation of the genetic code and its function in protein synthesis.”

Several years later, Khorana created the first synthetic gene — a step that led to commercialized gene synthesis at businesses around the world.

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(Original Caption) Nobel Prize Winners. Stockholm: The 1968 Nobel Prize recipients, five Americans and one Japanese where judged to have "most benefited mankind" in the past year. They appear here at the awards ceremony. Left to right: Professor H. Gobind Khorana, Robert W. Holley, Professor Luis W. Alvarez, Dr. Marshall W. Nirenberg, Lars Onsager and Japanese author Yasunari Kawabata.

Bettmann—Bettmann Archive
 
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Har Gobind Khorana deciphered DNA and wrote the dictionary for our genetic language
Tuesday’s Google Doodle honors the pioneering biochemist and Nobel Laureate.
By Umair Irfan Updated Jan 9, 2018, 2:59pm EST TWEET
har_gobind_khoranas_96th_birthday_4731112378073088_2x.0.jpg
Rohan Dahotre/Google
Our understanding of how genes shape us owes much to the work of Har Gobind Khorana, the Indian-American biochemist celebrated in Tuesday’s Google Doodle on what would have been Khorana’s 96th birthday.

Khorana, depicted in the doodle by Bangalore-based illustrator Rohan Dahotre, shared the 1968 Nobel Prize in physiology/medicine with Robert Holley and Marshall Nirenberg “for their interpretation of the genetic code and its function in protein synthesis.”

Working independently of each other, the researchers mapped out what’s now the central dogma of biology — that information is stored in DNA, a genetic instruction manual, and then transcribed into RNA, which in turn is translated into the language of proteins.

The world-renowned scientist’s illustrious career blossomed from humble roots. Uncertain of his own birthdate (he guessed it was January 9), Khorana was the fifth child born to a Hindu family in 1922 in Raipur, a 100-person village in the Punjab region of what is now Pakistan.

He started his education at a village school that met under a tree and quickly demonstrated an aptitude for science, tempered with humility. He received a scholarship to study chemistry at Punjab University in Lahore, but he was too shy to attend the mandatory admissions interview and considered majoring in English instead.

The admissions committee was still impressed enough with Khorana’s application that they enrolled him anyway. He went on to earn undergraduate and master’s degrees in chemistry at Punjab University, followed by a doctorate in organic chemistry at the University of Liverpool in England.

His friend Uttam L. RajBhandary, a molecular biology professor at the Massachusetts Institute of Technology, said Khorana was drawn to solving tough, critical problems. “He was not influenced by its difficulty or the time needed to solve it, as long as it was of fundamental importance,” RajBhandary wrote.

Khorana did stints in research institutions in Switzerland and Canada before landing at the Institute for Enzyme Research and the University of Wisconsin, Madison. There, he decoded how cells read the language of RNA written in structures represented by the letters A, C, U, and G. He did this by using enzymes to create sequences of these letters. Arranging them into distinct patterns, he and other scientists found that the genetic code comprised 64 three-letter “words,” known as codons.

The words code instructions for arranging amino acids, the basic units of proteins. The sequence “GGT” codes the amino acid glycine, for example, while the “UAA” codon tells cellular machinery to stop adding to a nascent protein.

Put together, the findings yielded something of a Rosetta Stone for genetics, bridging the divide between molecular instructions and the machinery they build.

genetic_code_acgt_lg__1_.jpg

A table showing the three-letter RNA codons associated with proteins
National Institutes of Health
Khorana went on to develop a way to make a synthetic gene and then place the lab-made gene in a living bacterium. The tiny engineered organism was a massive leap forward, helping launch the biotechnology sector and blazing a trail for scientists looking to manipulate life at its most fundamental levels, including recent work on editing genomes using the CRISPR/Cas9 system.

Khorana was working across the fields of chemistry, biology, and physics years before interdisciplinary research was common. One of his students, Michael Smith, went on to receive the 1993 Nobel Prize in Chemistry for work on creating artificial mutations in DNA.

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Har Gobind Khorana
Apic/Getty Images
Khorana became a US citizen in 1966 and faculty member at MIT in 1970, retiring in 2007.

Despite his accomplishments, Khorana’s friends described him as a modest man who avoided publicity. Nonetheless, he maintained his scientific curiosity until the end. RajBhandary wrote that three days before Khorana died, “I was by his hospital bed and we talked about glucose and the brain.”

Khorana died November 9, 2011, at the age of 89.


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:rofl::rofl::rofl: Another fantasy based on Internet heresy.
The Bakhshali Pakistan manuscript: The world's oldest zero?
October 26, 2017, University of Alberta


Last month, the Bodleian Library at Oxford University announced that a Sanskrit manuscript housed in the library for the last century had been dated using radiocarbon techniques. Oxford's radiocarbon dating laboratory announced that the three of the birch-bark folios of the Bakhshali Manuscript could be dated to roughly 300 CE, 700 CE and 900 CE.
The key result was, the library said, that one of the manuscript's leaves contained the oldest known written zero.

The library also announced that the zero in the manuscript was not a "true" zero, in the sense that it functioned only as a marker showing an empty decimal place, and not as a fully-fledged number that participates in calculations.

An international group of historians of Indian mathematics has now challenged Oxford's findings.

The team, which includes scholars from universities in the USA, France, Japan, New Zealand and the University of Alberta in Canada, has published a peer-reviewed article that refutes several of the Library's key assertions.

The scholars argue that the work written on the leaves of the Bakhshali manuscript is a unified treatise on arithmetic that must have been written at the time of the latest of the manuscript's leaves, not the earliest. The treatise shows no signs of being a jumble of fragments from different periods. Both the handwriting and the topic being discussed are continuous across the boundary of the first two dated leaves. It looks very much as if the scribe, who may have lived at the end of the eighth century, wrote out his treatise on a group of leaves that had been manufactured at very different times.

But of greater significance for the history of mathematics is the authors' evidence showing that the Bakhshali treatise does indeed know the "true" zero, and contains calculations like long multiplication that would have necessitated using zero as an arithmetical number. Furthermore, the treatise even contains a statement saying, "having added one to zero...," thus proving that the early Sanskrit author was thinking about zero in a numerical way.

The zero in the Bakhshali treatise is younger, but more important than Oxford claimed.

The international team ends its article with a plea to Oxford University's Library that important and complex scholarly topics should be published through established academic channels involving peer-review, and not through sensationalizing press releases to the media.

Explore further: Video: Earliest recorded use of zero is centuries older than first thought

More information: Dominik Wujastyk et al, The Bakhshālī Manuscript: A Response to the Bodleian Library's Radiocarbon Dating, History of Science in South Asia (2017). DOI: 10.18732/H2XT07

Provided by: University of Alberta

Video: Earliest recorded use of zero is centuries older than first thought
September 15, 2017, University of Oxford


Earliest recorded use of zero is centuries older than first thought. Credit: University of Oxford

Scientists from the University of Oxford's Bodleian Libraries have used carbon dating to trace the figure's origins to the famous ancient Indian scroll, the Bakhshali manuscript. The text dates back to the third or fourth century, making it the oldest recorded use of the symbol.

The research was commissioned by Bodleian Libraries, where the manuscript has been held since 1902. The text was found to contain hundreds of zeroes, and the landmark finding puts the birth of 'zero' or 'nought' as it is also known, at 500 years earlier than scholars first thought.

The concept of the symbol as we know and use it today, began as a simple dot, which was widely used as a 'placeholder' to represent orders of magnitude in the ancient Indian numbers system – for example 10s, 100s and 1000s. It features prominently in the Bakhshali manuscript, which is widely acknowledged as the oldest Indian mathematical text.

The earliest recorded example of the use of zero was previously believed to be a 9th century inscription of the symbol on the wall of a temple in Gwalior, Madhya Pradesh. The study findings predate this event and therefore have great historical mathematical significance.

Although a number of ancient cultures including the ancient Mayans and Babylonians also used the zero placeholder, the dot's use in the Bakhshali manuscript is the one that ultimately evolved into the symbol that we use today. India was also the place where the symbolic placeholder developed into a number in its own right, and the concept of the figure zero as it exists today, was born.
Credit: University of Oxford
Marcus du Sautoy, Professor of Mathematics at the University of Oxford, said: "Today we take it for granted that the concept of zero is used across the globe and is a key building block of the digital world. But the creation of zero as a number in its own right, which evolved from the placeholder dot symbol found in the Bakhshali manuscript, was one of the greatest breakthroughs in the history of mathematics.

"We now know that it was as early as the 3rd century that mathematicians in India planted the seed of the idea that would later become so fundamental to the modern world. The findings show how vibrant mathematics have been in the Indian sub-continent for centuries."

The Bakhshali manuscript was found in 1881, buried in a field in what was then an Indian village called Bakhshali, now in Pakistan. It is broadly recognised as the oldest Indian mathematical text, however, the exact age of the text is widely contested. The most conclusive academic study on the subject, was conducted by Japanese scholar Dr Hayashi Takao, and, based on factors such as the style of writing and the literary and mathematical content, it asserted that it probably dated from between the 8th and the 12th century. The new carbon dating reveals that the reason why it was previously so difficult for scholars to pinpoint the Bakhshali manuscript's date is because the manuscript, which consists of 70 fragile leaves of birch bark, is in fact composed of material from at least three different periods.

Richard Ovenden, Bodley's Librarian, said: "Determining the date of the Bakhshali manuscript is of vital importance to the history of mathematics and the study of early South Asian culture and these surprising research results testify to the subcontinent's rich and longstanding scientific tradition. The project is an excellent example of the cutting-edge research conducted by the Bodleian's Heritage Science team, together with colleagues across Oxford University, which uncovers new information about the treasures in our collections to help inform scholarship across disciplines."

Explore further: Founding document of mathematics published in digital form for the first time



Read more at: https://phys.org/news/2017-09-video-earliest-centuries-older-thought.html#jCp
 
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LOL ....Nice try appropriating another Hindu invention.

Muhammad was not even born when Aryabhat was clocking Algebraic expressions day and night. Aryabhatia predates Koran.

You only start appreciating good points if people are anyway related to Pakistan.



:rofl::rofl::rofl: Another fantasy based on Internet heresy.
You are just a stupid troll.
I respect anything good a person does.

Grow up!
 
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You are just a stupid troll.
I respect anything good a person does.

Grow up!

You are neither OP nor shown any of your work or posts to prove your claim.

You only came in this thread to call names.

You called me Indiot when I could have called you Porki.
 
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It was Pakistan who gave "0" to the world:pakistan:

Do not take me wrong...I am equally happy to see positive things about Pakistan and wish you all the best for progress...But it is also a fact, usually, it does not happen from Pakistan people to appreciate any Hindu people..
 
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You are neither OP nor shown any of your work or posts to prove your claim.

You only came in this thread to call names.

You called me Indiot when I could have called you Porki.
Listen Indiot, I don't have time for your nonsense. This is a Pakistani forum, I called you names because you are lying.

Muslims did invent algebra. Not your nonsense.

Do not take me wrong...I am equally happy to see positive things about Pakistan and wish you all the best for progress...But it is also a fact, usually, it does not happen from Pakistan people to appreciate any Hindu people..
I can appreciate anyone doing good whether they come from a Buddhist, Catholic, Muslim, or Hindu background.

You are neither OP nor shown any of your work or posts to prove your claim.

You only came in this thread to call names.

You called me Indiot when I could have called you Porki.
Listen you liar,

Even wikipedia says Muslims invented Algebra. This is undisputed fact.
from wikipedia
You cannot tolerate anything good associated with Muslims.
The word algebra comes from the Arabic الجبر (al-jabr lit. "the reunion of broken parts") from the title of the book Ilm al-jabr wa'l-muḳābala by the Persian mathematician and astronomer al-Khwarizmi. The word entered the English language during the fifteenth century, from either Spanish, Italian, or Medieval Latin. It originally referred to the surgical procedure of setting broken or dislocated bones. The mathematical meaning was first recorded in the sixteenth century.[5]

https://en.wikipedia.org/wiki/Algebra

It wasn't some ancient Hindus who invented Algebra.

Heck even Algebra is an Arabic word, not Sanskirt.

So don't tell lies here.

It was a Muslim who invented Algebra.

Now go cry me a river.
 
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LOL... Add Pakistan to everything that even predated inception of Pakistan in 1947.

Manuscript named as Bakhshali by a Gora because it was found in Bakshali village. What was that Manuscript doing in a field. LOL ... Looks like some primitive Jihadi was taking away Hindu loot back to Afghanistan when this book dropped from his Donkey's back.

The carbon dating contents showed it to be a work from AD 224–383, 680–779, and 885–993. And its mathematical concepts relates to work done by 7th century Bhashkara 1 succeeding Aryabhatt of 5th Century.

The script Sharda belongs to Kashmiri Pandits which Pakistan sponsored genocide and made them to be kicked out from their homelands. LOL Irony in Pakistani claims is too slippery to stand its own misery. LOL.
lol I am calling the mods to deal with you.
@waz, @The Eagle, Please take care of this Indian troll.

The Indian troll did not even answer my Algebra post. lol.

LOL... Add Pakistan to everything that even predated inception of Pakistan in 1947.

Manuscript named as Bakhshali by a Gora because it was found in Bakshali village ??? What was that Manuscript doing in a field. LOL ... Looks like some primitive Jihadi was taking away Hindu loot back to Afghanistan when this book dropped from his Donkey's back.

The carbon dating contents showed it to be a work from AD 224–383, 680–779, and 885–993. And its mathematical concepts relates to work done by 7th century Bhashkara 1 succeeding Aryabhatt of 5th Century.

The script Sharda belongs to Kashmiri Pandits which Pakistan sponsored genocide and made them to be kicked out from their homelands. LOL Irony in Pakistani claims is too slippery to stand its own misery. LOL.
The zero in the script was discovered in Pakistan, and not India.

Therefore it is a Pakistani historical fact not an Indian fact.

Get your facts straight troll.
 
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