JSCh
ELITE MEMBER
- Joined
- Jun 9, 2011
- Messages
- 13,235
- Reaction score
- 2
- Country
- Location
January 11, 2021 1:06 pm
It is the first documented case of positivity in a human being. The study was conducted by a group of pathologists from the State University, in collaboration with the Ieo and the Italian Diagnostic Center
The group of pathologists collaborated with the Ieo and with the Italian Diagnostic Center. The study was instead published in the British Journal of dermatology, the most renowned magazine in the dermatological field. Based on the data in the world literature, this is the oldest evidence of the presence of the SARS-CoV-2 virus in a human being. The 25-year-old presented how dermatosis is the only symptom. Contacted retrospectively, she reported the absence of systemic symptoms of Covid-19 infection, the disappearance of skin lesions after five months and the positivity of antibodies to SARS-CoV-2 in the peripheral blood in June 2020.
Skin pathologies are present in approx 5-10% of patients with Covid-19 infection. The group of pathologists re-examined skin biopsies of atypical dermatoses observed in autumn 2019 with surprising results. Raffaele Gianotti, dermatopathologist of the University of Milan and of the Cà Granda Foundation Ospedale Maggiore Policlinico of Milan, explains how the studio was born: “After studying the skin manifestations in patients affected by Covid-19 in the Milan area, I re-examined under the microscope the biopsies of atypical skin diseases performed at the end of 2019 in which it was not possible to make a precise diagnosis. We have searched in the past because in our works already published in international journals, we have shown that there are, in this pandemic, cases in which the the only sign of Covid-19 infection is that of a skin pathology. I wondered if we could find any clues to the presence of SARS-CoV-2 in the skin of patients with only skin diseases before the officially recognized epidemic phase began. ”
The biopsy of a young woman, dating back to November 2019, showed the presence of RNA gene sequences of the SARS-CoV-2 virus, identified through two different techniques on skin tissue: immunohistochemistry and Rna-Fish. Metaphorically we found Covid-19’s “fingerprints” in the skin tissue. Giovanni Fellegara, head of the Pathological Anatomy Laboratory of the Italian Diagnostic Center, comments: “In the case of the 25-year-old it was possible to demonstrate immunohistochemical investigations carried out in our laboratory the presence of viral antigens in the sweat glands“This data was then confirmed by the finding in the same gene sequence structures of the viral RNA identified with the Rna-Fish technique performed at the European Institute of Oncology.
“We have demonstrated the presence of SARS-CoV-2 viral sequences, even quantitatively scarce, on the histological preparation of 2019 and also in six patients in 2020 suffering only from dermatosis but without systemic symptoms of Covid-19 infection “he adds Massimo Barberis, director of the Clinical Unit of Histopathological and Molecular Diagnostics of the European Institute of Oncology.
www.italy24news.com
It is the first documented case of positivity in a human being. The study was conducted by a group of pathologists from the State University, in collaboration with the Ieo and the Italian Diagnostic Center
The group of pathologists collaborated with the Ieo and with the Italian Diagnostic Center. The study was instead published in the British Journal of dermatology, the most renowned magazine in the dermatological field. Based on the data in the world literature, this is the oldest evidence of the presence of the SARS-CoV-2 virus in a human being. The 25-year-old presented how dermatosis is the only symptom. Contacted retrospectively, she reported the absence of systemic symptoms of Covid-19 infection, the disappearance of skin lesions after five months and the positivity of antibodies to SARS-CoV-2 in the peripheral blood in June 2020.
Skin pathologies are present in approx 5-10% of patients with Covid-19 infection. The group of pathologists re-examined skin biopsies of atypical dermatoses observed in autumn 2019 with surprising results. Raffaele Gianotti, dermatopathologist of the University of Milan and of the Cà Granda Foundation Ospedale Maggiore Policlinico of Milan, explains how the studio was born: “After studying the skin manifestations in patients affected by Covid-19 in the Milan area, I re-examined under the microscope the biopsies of atypical skin diseases performed at the end of 2019 in which it was not possible to make a precise diagnosis. We have searched in the past because in our works already published in international journals, we have shown that there are, in this pandemic, cases in which the the only sign of Covid-19 infection is that of a skin pathology. I wondered if we could find any clues to the presence of SARS-CoV-2 in the skin of patients with only skin diseases before the officially recognized epidemic phase began. ”
The biopsy of a young woman, dating back to November 2019, showed the presence of RNA gene sequences of the SARS-CoV-2 virus, identified through two different techniques on skin tissue: immunohistochemistry and Rna-Fish. Metaphorically we found Covid-19’s “fingerprints” in the skin tissue. Giovanni Fellegara, head of the Pathological Anatomy Laboratory of the Italian Diagnostic Center, comments: “In the case of the 25-year-old it was possible to demonstrate immunohistochemical investigations carried out in our laboratory the presence of viral antigens in the sweat glands“This data was then confirmed by the finding in the same gene sequence structures of the viral RNA identified with the Rna-Fish technique performed at the European Institute of Oncology.
“We have demonstrated the presence of SARS-CoV-2 viral sequences, even quantitatively scarce, on the histological preparation of 2019 and also in six patients in 2020 suffering only from dermatosis but without systemic symptoms of Covid-19 infection “he adds Massimo Barberis, director of the Clinical Unit of Histopathological and Molecular Diagnostics of the European Institute of Oncology.
Covid, Italian patient zero found: she is a 25-year-old who was found to have the virus in November 2019
January 11, 2021 1:06 pm It is the first documented case of positivity in a human being. The study was conducted by a group of pathologists from the State University, in collaboration with the Ieo …
www.italy24news.com
