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Covid-19 vaccines help prevent breakthrough infections even in immune-compromised people, study shows
From CNN's Maggie Fox
The Covid-19 vaccine is administered at a pop-up clinic in the international arrivals section of Los Angeles International Airport in Los Angeles, California on December 22, 2021. (Frederic J. Brown/AFP/Getty Images)
Covid-19 vaccines help prevent breakthrough infections even among immune-compromised people such as organ transplant recipients and rheumatoid arthritis patients, researchers reported Tuesday.
But these patients are at higher risk of breakthroughs than other vaccinated people and should take extra precautions, the researchers reported.
Dr. Jing Sun, an epidemiologist at the Johns Hopkins University Bloomberg School of Public Health and colleagues studied the records of 660,000 people who received at least one dose of a coronavirus vaccine through Sept. 16.
“People with a breakthrough infection after full vaccination were more likely to be older and women. People with HIV infection, rheumatoid arthritis, and solid organ transplant had a higher rate of breakthrough infection,” they wrote.
People with other types of immunocompromising conditions did not have higher rates of breakthrough infections, they found.
Vaccination protected everyone, the researchers reported. But they said those getting immune-suppressing drugs for rheumatoid arthritis or because of organ transplants, as well as HIV patients, should take care to wear masks and avoid situations where they might be exposed.
Dr. Mary Nakamura, an immunologist at the San Francisco VA Health Care System, and rheumatologist Dr. Alfred Kim of Washington University School of Medicine in St. Louis, said the findings should encourage the immune-compromised to get vaccinated and boosted.
“SARS-CoV-2 vaccine clinical trials did not initially include individuals with immune dysfunction conditions, which has led to some hesitancy in using the available vaccines in this population,” they wrote in an accompanying commentary.
“However, several recent retrospective studies have reported reassuring data regarding the safety of these vaccines in immunocompromised patients, and the general consensus is that the potential benefits of vaccination substantially outweigh the risks," the said.
From CNN's Maggie Fox
The Covid-19 vaccine is administered at a pop-up clinic in the international arrivals section of Los Angeles International Airport in Los Angeles, California on December 22, 2021. (Frederic J. Brown/AFP/Getty Images)
Covid-19 vaccines help prevent breakthrough infections even among immune-compromised people such as organ transplant recipients and rheumatoid arthritis patients, researchers reported Tuesday.
But these patients are at higher risk of breakthroughs than other vaccinated people and should take extra precautions, the researchers reported.
Dr. Jing Sun, an epidemiologist at the Johns Hopkins University Bloomberg School of Public Health and colleagues studied the records of 660,000 people who received at least one dose of a coronavirus vaccine through Sept. 16.
“Overall, the incidence rate for COVID-19 breakthrough infection was 5.0 per 1,000 person-months among fully vaccinated persons but was higher after the Delta variant became the dominant SARS-CoV-2 strain,” they said. Before June, the rate of breakthrough infections was 2.2 per 1,000 people per year. That rose to 7.3 afterward, as Delta spread.
“People with a breakthrough infection after full vaccination were more likely to be older and women. People with HIV infection, rheumatoid arthritis, and solid organ transplant had a higher rate of breakthrough infection,” they wrote.
People with other types of immunocompromising conditions did not have higher rates of breakthrough infections, they found.
Vaccination protected everyone, the researchers reported. But they said those getting immune-suppressing drugs for rheumatoid arthritis or because of organ transplants, as well as HIV patients, should take care to wear masks and avoid situations where they might be exposed.
Dr. Mary Nakamura, an immunologist at the San Francisco VA Health Care System, and rheumatologist Dr. Alfred Kim of Washington University School of Medicine in St. Louis, said the findings should encourage the immune-compromised to get vaccinated and boosted.
“SARS-CoV-2 vaccine clinical trials did not initially include individuals with immune dysfunction conditions, which has led to some hesitancy in using the available vaccines in this population,” they wrote in an accompanying commentary.
“However, several recent retrospective studies have reported reassuring data regarding the safety of these vaccines in immunocompromised patients, and the general consensus is that the potential benefits of vaccination substantially outweigh the risks," the said.
