Khanivore
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Note to China Bashers Brigade: it's from a prominent Hong Kong paper. 
TWO very interesting articles below...
West kind of admitting and giving up on blaming China? Please comment below.
Coronavirus: pathogen could have been spreading in humans for decades, study says
Published: 4:30pm, 29 Mar, 2020
The coronavirus that causes Covid-19 might have been quietly spreading among humans for years or even decades before the sudden outbreak that sparked a global health crisis, according to an investigation by some of the world’s top virus hunters.
Researchers from the United States, Britain and Australia looked at piles of data released by scientists around the world for clues about the virus’ evolutionary past, and found it might have made the jump from animal to humans long before the first detection in the central China city of Wuhan.
Though there could be other possibilities, the scientists said the coronavirus carried a unique mutation that was not found in suspected animal hosts, but was likely to occur during repeated, small-cluster infections in humans.
The study, conducted by Kristian Andersen from the Scripps Research Institute in California, Andrew Rambaut from the University of Edinburgh in Scotland, Ian Lipkin from Columbia University in New York, Edward Holmes from the University of Sydney, and Robert Garry from Tulane University in New Orleans, was published in the scientific journal Nature Medicine on March 17.
Dr Francis Collins, director of the US National Institute of Health, who was not involved in the research, said the study suggested a possible scenario in which the coronavirus crossed from animals into humans before it became capable of causing disease in people.
“Then, as a result of gradual evolutionary changes over years or perhaps decades, the virus eventually gained the ability to spread from human to human and cause serious, often life-threatening disease,” he said in an article published on the institute’s website on Thursday.
In December, doctors in Wuhan began noticing a surge in the number of people suffering from a mysterious pneumonia. Tests for flu and other pathogens returned negative. An unknown strain was isolated, and a team from the Wuhan Institute of Virology led by Shi Zhengli traced its origin to a bat virus found in a mountain cave close to the China-Myanmar border.
The two viruses shared more than 96 per cent of their genes, but the bat virus could not infect humans. It lacked a spike protein to bind with receptors in human cells.
Coronaviruses with a similar spike protein were later discovered in Malayan pangolins by separate teams from Guangzhou and Hong Kong, which led some researchers to believe that a recombination of genomes had occurred between the bat and pangolin viruses.
But the new strain, or SARS-Cov-2, had a mutation in its genes known as a polybasic cleavage site that was unseen in any coronaviruses found in bats or pangolins, according to Andersen and his colleagues.
This mutation, according to separate studies by researchers from China, France and the US, could produce a unique structure in the virus’ spike protein to interact with furin, a widely distributed enzyme in the human body. That could then trigger a fusion of the viral envelope and human cell membrane when they came into contact with one another.
Some human viruses including HIV and Ebola have the same furin-like cleavage site, which makes them contagious.
It is possible that the mutation happened naturally to the virus on animal hosts. Sars (severe acute respiratory syndrome) and Mers (Middle East respiratory syndrome), for instance, were believed to have been direct descendants of species found in masked civets and camels, which had a 99 per cent genetic similarity.
There was, however, no such direct evidence for the novel coronavirus, according to the international team. The gap between human and animal types was too large, they said, so they proposed another alternative.
“It is possible that a progenitor of SARS-CoV-2 jumped into humans, acquiring the genomic features described above through adaptation during undetected human-to-human transmission,” they said in the paper.
“Once acquired, these adaptations would enable the pandemic to take off and produce a sufficiently large cluster of cases to trigger the surveillance system that detected it.”
They said also that the most powerful computer models based on current knowledge about the coronavirus could not generate such a strange but highly efficient spike protein structure to bind with host cells.
The study had significantly reduced, if not ruled out, the possibility of a laboratory origin, Collins said.
“In fact, any bioengineer trying to design a coronavirus that threatened human health probably would never have chosen this particular conformation for a spike protein,” he said.
The findings by Western scientists echoed the mainstream opinion among Chinese researchers. [take note, you people in India]
Zhong Nanshan, who advises Beijing on outbreak containment policies, had said on numerous occasions that there was growing scientific evidence to suggest the origin of the virus might not have been in China.
“The occurrence of Covid-19 in Wuhan does not mean it originated in Wuhan,” he said last week.
A doctor working in a public hospital treating Covid-19 patients in Beijing said numerous cases of mysterious pneumonia outbreaks had been reported by health professionals in several countries last year.
Re-examining the records and samples of these patients could reveal more clues about the history of this worsening pandemic, said the doctor, who asked not to be named due to the political sensitivity of the issue.
“There will be a day when the whole thing comes to light.”
Italian professor repeats warning coronavirus may have spread outside China last year
Published: 11:22pm, 24 Mar, 2020
The coronavirus that causes Covid-19 may have spread beyond China before the health authorities had even discovered the disease, according to the Italian professor who recently said there had been “very strange pneumonia” in Europe as early as November last year.
The comments by Giuseppe Remuzzi, director of the Mario Negri Institute for Pharmacological Research in Milan, during an interview with US National Public Radio last week were quickly seized upon in the increasingly acrimonious blame game between Washington and Beijing.
Remuzzi’s comments attracted much attention in China, where the authorities have been working hard to steer the international narrative about the pandemic, and stop people describing it as the “China virus” or “Wuhan virus” after the city where the disease was first identified.
In an interview with the Chinese science and technology news outlet DeepTech, which was published on Tuesday, Remuzzi said the key point in his NPR interview was not where the virus came from, but how far it had spread before it was discovered.
He said a major question was how long the disease, which has so far infected more than 378,000 and killed over 16,500 people worldwide, had been spreading in China before health authorities realised its severity.
Taking into account the long incubation period, Remuzzi said he would not be surprised if some asymptomatic carriers had travelled around China or even abroad before December.
The professor also said that while it was possible it originated outside Wuhan, there had so far been no proof to support the theory.
As the outbreak gathered pace in the US, where it has now killed more than 500 people, Washington has escalated its rhetoric. President Donald Trump had repeatedly referred to it publicly as the “Chinese virus” until he changed tone on Monday and declined to use the phrase.
China, meanwhile, has described the rhetoric adopted by “certain US politicians and senior officials” as an attempt to defame and stigmatise China over the pandemic.
A number of Chinese state media outlets, including party mouthpiece People’s Daily and its tabloid affiliate Global Times, seized on Remuzzi’s comments about “strange pneumonias” to counter the “Chinese virus rhetoric”.
In the NPR interview, Remuzzi tried to explain why Italy had been caught off guard when the outbreak started gathering pace in February.
He discussed the difficulty of combating a disease that people did not know existed, and said the unusual cases in November and December could mean that virus was already circulating in Lombardy, the country’s worst-hit region, before people were aware of what was unfolding in Wuhan.
Remuzzi also shared details of the early suspected cases in Lombardy with DeepTech and Chinese state-run international network CGTN.
Remuzzi said he had learned about the cases from a few general practitioners and he has not yet been able to verify the information.
But he said there are some other suspicious cases he “knows for sure”, including two pneumonia cases in Scanzorosciate in northern Italy in December, where the patients developed high fever, a cough and had difficulty in breathing.
He said there had also been 10 patients who developed bilateral interstitial pneumonia in two other nearby towns, Fara Gera D’Adda and Crema, who had similar symptoms.
Remuzzi said local doctors considered these cases to be “unusual” but ruled out the possibility of seasonal influenza, as all these patients had been vaccinated.
“The reason we don’t know if it was Covid-19 is because at that time this could not be tested; the patients didn’t have X-rays,” he told CGTN.
They recovered within 15 days, with some receiving two or three courses of antibiotics.
Remuzzi added there had also been a patient diagnosed with bilateral interstitial pneumonia in Alzano Lombardo Hospital in Lombardy around the time.
TWO very interesting articles below...
West kind of admitting and giving up on blaming China? Please comment below.
Coronavirus: pathogen could have been spreading in humans for decades, study says
- Virus may have jumped from animal to humans long before the first detection in Wuhan, according to research by an international team of scientists
- Findings significantly reduce the possibility of the virus having a laboratory origin, director of the US National Institute of Health says
Published: 4:30pm, 29 Mar, 2020
The coronavirus that causes Covid-19 might have been quietly spreading among humans for years or even decades before the sudden outbreak that sparked a global health crisis, according to an investigation by some of the world’s top virus hunters.
Researchers from the United States, Britain and Australia looked at piles of data released by scientists around the world for clues about the virus’ evolutionary past, and found it might have made the jump from animal to humans long before the first detection in the central China city of Wuhan.
Though there could be other possibilities, the scientists said the coronavirus carried a unique mutation that was not found in suspected animal hosts, but was likely to occur during repeated, small-cluster infections in humans.
The study, conducted by Kristian Andersen from the Scripps Research Institute in California, Andrew Rambaut from the University of Edinburgh in Scotland, Ian Lipkin from Columbia University in New York, Edward Holmes from the University of Sydney, and Robert Garry from Tulane University in New Orleans, was published in the scientific journal Nature Medicine on March 17.
Dr Francis Collins, director of the US National Institute of Health, who was not involved in the research, said the study suggested a possible scenario in which the coronavirus crossed from animals into humans before it became capable of causing disease in people.
“Then, as a result of gradual evolutionary changes over years or perhaps decades, the virus eventually gained the ability to spread from human to human and cause serious, often life-threatening disease,” he said in an article published on the institute’s website on Thursday.
In December, doctors in Wuhan began noticing a surge in the number of people suffering from a mysterious pneumonia. Tests for flu and other pathogens returned negative. An unknown strain was isolated, and a team from the Wuhan Institute of Virology led by Shi Zhengli traced its origin to a bat virus found in a mountain cave close to the China-Myanmar border.
The two viruses shared more than 96 per cent of their genes, but the bat virus could not infect humans. It lacked a spike protein to bind with receptors in human cells.
Coronaviruses with a similar spike protein were later discovered in Malayan pangolins by separate teams from Guangzhou and Hong Kong, which led some researchers to believe that a recombination of genomes had occurred between the bat and pangolin viruses.
But the new strain, or SARS-Cov-2, had a mutation in its genes known as a polybasic cleavage site that was unseen in any coronaviruses found in bats or pangolins, according to Andersen and his colleagues.
This mutation, according to separate studies by researchers from China, France and the US, could produce a unique structure in the virus’ spike protein to interact with furin, a widely distributed enzyme in the human body. That could then trigger a fusion of the viral envelope and human cell membrane when they came into contact with one another.
Some human viruses including HIV and Ebola have the same furin-like cleavage site, which makes them contagious.
It is possible that the mutation happened naturally to the virus on animal hosts. Sars (severe acute respiratory syndrome) and Mers (Middle East respiratory syndrome), for instance, were believed to have been direct descendants of species found in masked civets and camels, which had a 99 per cent genetic similarity.
There was, however, no such direct evidence for the novel coronavirus, according to the international team. The gap between human and animal types was too large, they said, so they proposed another alternative.
“It is possible that a progenitor of SARS-CoV-2 jumped into humans, acquiring the genomic features described above through adaptation during undetected human-to-human transmission,” they said in the paper.
“Once acquired, these adaptations would enable the pandemic to take off and produce a sufficiently large cluster of cases to trigger the surveillance system that detected it.”
They said also that the most powerful computer models based on current knowledge about the coronavirus could not generate such a strange but highly efficient spike protein structure to bind with host cells.
The study had significantly reduced, if not ruled out, the possibility of a laboratory origin, Collins said.
“In fact, any bioengineer trying to design a coronavirus that threatened human health probably would never have chosen this particular conformation for a spike protein,” he said.
The findings by Western scientists echoed the mainstream opinion among Chinese researchers. [take note, you people in India
]Zhong Nanshan, who advises Beijing on outbreak containment policies, had said on numerous occasions that there was growing scientific evidence to suggest the origin of the virus might not have been in China.
“The occurrence of Covid-19 in Wuhan does not mean it originated in Wuhan,” he said last week.
A doctor working in a public hospital treating Covid-19 patients in Beijing said numerous cases of mysterious pneumonia outbreaks had been reported by health professionals in several countries last year.
Re-examining the records and samples of these patients could reveal more clues about the history of this worsening pandemic, said the doctor, who asked not to be named due to the political sensitivity of the issue.
“There will be a day when the whole thing comes to light.”
Italian professor repeats warning coronavirus may have spread outside China last year
- Giuseppe Remuzzi’s comments were seized on by Chinese state media amid the acrimonious row with the US, but he says the key question is how far Covid-19 had spread before it was identified
- Academic says ‘strange pneumonias’ in Italy last November suggest it may have reached Europe before anyone knew what the disease was
Published: 11:22pm, 24 Mar, 2020
The coronavirus that causes Covid-19 may have spread beyond China before the health authorities had even discovered the disease, according to the Italian professor who recently said there had been “very strange pneumonia” in Europe as early as November last year.
The comments by Giuseppe Remuzzi, director of the Mario Negri Institute for Pharmacological Research in Milan, during an interview with US National Public Radio last week were quickly seized upon in the increasingly acrimonious blame game between Washington and Beijing.
Remuzzi’s comments attracted much attention in China, where the authorities have been working hard to steer the international narrative about the pandemic, and stop people describing it as the “China virus” or “Wuhan virus” after the city where the disease was first identified.
In an interview with the Chinese science and technology news outlet DeepTech, which was published on Tuesday, Remuzzi said the key point in his NPR interview was not where the virus came from, but how far it had spread before it was discovered.
He said a major question was how long the disease, which has so far infected more than 378,000 and killed over 16,500 people worldwide, had been spreading in China before health authorities realised its severity.
Taking into account the long incubation period, Remuzzi said he would not be surprised if some asymptomatic carriers had travelled around China or even abroad before December.
The professor also said that while it was possible it originated outside Wuhan, there had so far been no proof to support the theory.
As the outbreak gathered pace in the US, where it has now killed more than 500 people, Washington has escalated its rhetoric. President Donald Trump had repeatedly referred to it publicly as the “Chinese virus” until he changed tone on Monday and declined to use the phrase.
China, meanwhile, has described the rhetoric adopted by “certain US politicians and senior officials” as an attempt to defame and stigmatise China over the pandemic.
A number of Chinese state media outlets, including party mouthpiece People’s Daily and its tabloid affiliate Global Times, seized on Remuzzi’s comments about “strange pneumonias” to counter the “Chinese virus rhetoric”.
In the NPR interview, Remuzzi tried to explain why Italy had been caught off guard when the outbreak started gathering pace in February.
He discussed the difficulty of combating a disease that people did not know existed, and said the unusual cases in November and December could mean that virus was already circulating in Lombardy, the country’s worst-hit region, before people were aware of what was unfolding in Wuhan.
Remuzzi also shared details of the early suspected cases in Lombardy with DeepTech and Chinese state-run international network CGTN.
Remuzzi said he had learned about the cases from a few general practitioners and he has not yet been able to verify the information.
But he said there are some other suspicious cases he “knows for sure”, including two pneumonia cases in Scanzorosciate in northern Italy in December, where the patients developed high fever, a cough and had difficulty in breathing.
He said there had also been 10 patients who developed bilateral interstitial pneumonia in two other nearby towns, Fara Gera D’Adda and Crema, who had similar symptoms.
Remuzzi said local doctors considered these cases to be “unusual” but ruled out the possibility of seasonal influenza, as all these patients had been vaccinated.
“The reason we don’t know if it was Covid-19 is because at that time this could not be tested; the patients didn’t have X-rays,” he told CGTN.
They recovered within 15 days, with some receiving two or three courses of antibiotics.
Remuzzi added there had also been a patient diagnosed with bilateral interstitial pneumonia in Alzano Lombardo Hospital in Lombardy around the time.
