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China approves first mixed-vaccine trial as Delta spreads

Reashot Xigwin

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Issued on: 11/08/2021 - 11:30
The trial will test the efficacy of combining an 'inactivated' vaccine made by China's Sinovac with a DNA-based one

The trial will test the efficacy of combining an 'inactivated' vaccine made by China's Sinovac with a DNA-based one Lillian SUWANRUMPHA AFP/File
1 min

Beijing (AFP)
China's drug regulator has approved the country's first mixed-vaccine trial, a company involved in the study said, as the rapid spread of the Delta variant raises concern about the efficacy of domestically produced jabs.
The trial will test the efficacy of combining an "inactivated" vaccine made by China's Sinovac with a DNA-based one developed by US pharmaceutical company Inovio, a statement issued on Tuesday said.
The statement was put out by Advaccine Biopharmaceuticals Suzhou, Inovio's trial partner in China.

Preclinical work has found that "two different vaccine applications... produce an even stronger and more balanced immune response", Advaccine chairman Wang Bin said in the statement.
There are several types of Covid vaccines, including those using an inactivated or weakened virus to generate an immune response, and more cutting-edge RNA- or DNA-based jabs that use engineered versions of the coronavirus' genetic code to create a protein that safely prompts an immune response.
Five out of the seven vaccines approved in China are two-shot inactivated vaccines.
Their published efficacy lags RNA jabs by Pfizer-BioNTech and Moderna, which have pre-Delta success rates above 90 percent.
The World Health Organization has said there is still not enough data to say whether using two different vaccines together is safe or can boost immunity.
Inovio has not published any efficacy data from its global clinical trials. It is the first DNA-based vaccine to be trialled in China.

China is battling its worst coronavirus outbreak in months, with officials saying many of those infected had already been vaccinated.
This has added to calls for China's two biggest vaccine producers -- state-run Sinopharm and privately owned Sinovac -- to provide data proving their jabs work against the Delta variant.
Beijing is yet to approve any foreign vaccines for domestic use.
© 2021 AFP


:usflag:
 
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What happened to Fosun BioNTech? Not sure I understand why the Chinese are prioritizing Inovio over widely used Pfizer BioNTech?
 
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What happened to Fosun BioNTech? Not sure I understand why the Chinese are prioritizing Inovio over widely used Pfizer BioNTech?
Mostly because me think they can slap their chinese partner company name on the vaccine. Who's going to bet Xi's going to claim credit for the vaccine?

Also Inovio? I been researching covid & this is literally the 1st time I even heard of the company.
 
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pfizer is so effective that israel already on third dose? what's next? 4th, 5th, 6th, 8th ?like lab rats :D?

y9ynrtA.jpg

Meanwhile in chile...

Latest vaccine real-world data from Chile that has fully vaccinated >60% of population, mostly with Sinovac. Sinovac efficacy against symptomatic disease to 58.5% from 67% in April study. Chile official recommends booster dose as vaccine efficacy may further with Delta.
E8KFDrfVoAEKTcN
 
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What happened to Fosun BioNTech? Not sure I understand why the Chinese are prioritizing Inovio over widely used Pfizer BioNTech?
More interestingly, why not Cansino vaccine, which is another DNA-based vaccine and produced in China?
pfizer is so effective that israel already on third dose? what's next? 4th, 5th, 6th, 8th ?like lab rats :D?

y9ynrtA.jpg
Close to 0.5% death rate. That is about the same as flu. You may start to bitch about flu now.
 
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More interestingly, why not Cansino vaccine, which is another DNA-based vaccine and produced in China?

Close to 0.5% death rate. That is about the same as flu. You may start to bitch about flu now.

you mean ValVax? the Chinese mRNA vaccine being trialed in Mexico. I haven't heard anything about that trial either.

there are so many Chinese vaccines it's hard to keep track.
 
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you mean ValVax? the Chinese mRNA vaccine being trialed in Mexico. I haven't heard anything about that trial either.

there are so many Chinese vaccines it's hard to keep track.
No, Cansino, which produces a DNA vector based vaccine, much like AZ. This company was found by some Chinese who studied in Canada. Thus the name Can (Canada) Sino (China).
 
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What happened to Fosun BioNTech? Not sure I understand why the Chinese are prioritizing Inovio over widely used Pfizer BioNTech?

Chinese government cannot approve mRNA because it requires 10 years of observation to assess safety. Chinese safety standard is different from US safety standard.
No, Cansino, which produces a DNA vector based vaccine, much like AZ. This company was found by some Chinese who studied in Canada. Thus the name Can (Canada) Sino (China).

Viral vector can only be used once because of anti vector immunity after the first dose. DNA vaccine don't have that limitation.
 
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Issued on: 11/08/2021 - 11:30
The trial will test the efficacy of combining an 'inactivated' vaccine made by China's Sinovac with a DNA-based one'inactivated' vaccine made by China's Sinovac with a DNA-based one

The trial will test the efficacy of combining an 'inactivated' vaccine made by China's Sinovac with a DNA-based one Lillian SUWANRUMPHA AFP/File
1 min

Beijing (AFP)
China's drug regulator has approved the country's first mixed-vaccine trial, a company involved in the study said, as the rapid spread of the Delta variant raises concern about the efficacy of domestically produced jabs.
The trial will test the efficacy of combining an "inactivated" vaccine made by China's Sinovac with a DNA-based one developed by US pharmaceutical company Inovio, a statement issued on Tuesday said.
The statement was put out by Advaccine Biopharmaceuticals Suzhou, Inovio's trial partner in China.

Preclinical work has found that "two different vaccine applications... produce an even stronger and more balanced immune response", Advaccine chairman Wang Bin said in the statement.
There are several types of Covid vaccines, including those using an inactivated or weakened virus to generate an immune response, and more cutting-edge RNA- or DNA-based jabs that use engineered versions of the coronavirus' genetic code to create a protein that safely prompts an immune response.
Five out of the seven vaccines approved in China are two-shot inactivated vaccines.
Their published efficacy lags RNA jabs by Pfizer-BioNTech and Moderna, which have pre-Delta success rates above 90 percent.
The World Health Organization has said there is still not enough data to say whether using two different vaccines together is safe or can boost immunity.
Inovio has not published any efficacy data from its global clinical trials. It is the first DNA-based vaccine to be trialled in China.

China is battling its worst coronavirus outbreak in months, with officials saying many of those infected had already been vaccinated.
This has added to calls for China's two biggest vaccine producers -- state-run Sinopharm and privately owned Sinovac -- to provide data proving their jabs work against the Delta variant.
Beijing is yet to approve any foreign vaccines for domestic use.
© 2021 AFP


:usflag:
It's a trial, China will not appeove mrna anytime soon. We don't want mutated babies.
 
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No, Cansino, which produces a DNA vector based vaccine, much like AZ. This company was found by some Chinese who studied in Canada. Thus the name Can (Canada) Sino (China).

Yes I remember now, even the names are confusing CanSino, SinoVac, SinoPharm and Walvax. did I miss any?
 
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It's a trial, China will not appeove mrna anytime soon. We don't want mutated babies.

Risk of mutation of the mRNA vaccine is almost the same that of viral vector vaccine, considering viral vector vaccine is also use DNA that will enter the human cell and change to mRNA that instruct ribosome to produce spike protein.
Viral vector can only be used once because of anti vector immunity after the first dose. DNA vaccine don't have that limitation.

Sputnik use different viral vector on the second dose.
 
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Yes I remember now, even the names are confusing CanSino, SinoVac, SinoPharm and Walvax. did I miss any?

Clover and Anhui Zhifei Longcom both make protein subunit vaccines.



Sputnik use different viral vector on the second dose.

But they use Ad5 which is very common.
 
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Risk of mutation of the mRNA vaccine is almost the same that of viral vector vaccine, considering viral vector vaccine is also use DNA that will enter the human cell and change to mRNA that instruct ribosome to produce spike protein.


Sputnik use different viral vector on the second dose.
I have been hearing rumours of China using Mrna drugs for the past 1 year. And still heating it now....
 
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