naveen mishra
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he Role of Green Tea in Oral Health
Catechins are polyphenolic compounds derived from green tea plant leaves (Camellia sinensis). They have been reported to have a wide range of biological activities including prevention of tooth decay, oral cancer and other diseases.
Halitosis
Bad breath. Green tea can wipe out the cause and symptoms. Bacteria in the mouth are responsible for the foul smell of halitosis. Polyphenols in the catechin class contained in green tea have anti-bacterial qualities and halt the biological reactions that make the smelly sulfur compounds. Green tea can both inhibit bacterial growth and alter the enzyme required to drive the production of hydrogen sulfide during protein digestion. The simple treatment for bad breath is to gargle with green tea.
Catechin Delivery to the Mouth
A study from 2004 tested the usefulness of green tea leaves to deliver catechins to the mouth.1
Subjects held 2 grams of green tea leaves in their mouths for 2-5 minutes and thoroughly rinsed their mouths. High concentrations of catechins were detected in saliva within the first hour of rinsing the mouth. The peak concentrations of catechins occurred between 25 and 44 minutes after rinsing. Researchers concluded that green tea leaves have potential for use in the prevention of oral cancer and dental caries by offering a convenient, slow-release source of catechins.
During a subsequent study on holding or chewing green tea leaves in the mouth the same scientists reported that catechin oxidation results in hydrogen peroxide as a by-product of the reaction.2 Human volunteers held green tea solution at a strength ranging from 0.1% to 0.6%. On another day the volunteers chewed 2 grams of green tea leaves. The hydrogen peroxide produced when leaves were chewed was more than when green tea solution was held in the mouth. The scientists concluded that catechin-generated hydrogen peroxide may have a significant role in disease prevention by green tea.
Green Tea and Oral Cancer Prevention
A short-term study was conducted on patients with oral premalignant lesions.3 Treatments of green tea extract was randomly assigned at doses of 500, 750 or 1000 mg/m2 or placebo three times a day for 12 weeks. The response rate to green tea extract was higher than to the placebo at all dosage rates but none of the responses were statistically significant. Even so, the two highest dosage treatments had higher responses which could be there was a dose-response effect.
The researchers concluded that the green tea extract was well tolerated at low treatment rates but at higher rates reports of insomnia and/or nervousness were made. No toxicity effect was realized. As for treatment efficacy, researchers suggested that higher doses of green tea extract in 12-week trials may improve response rates. However, the results support longer-term clinical testing of green tea extract for oral cancer prevention.
The results of this study are significant, according to Dong M. Shin at Emory University in Georgia.4 Green tea extract was shown for the first time to have dose-dependent effects in a clinical chemopreventive setting (oral premalignant lesions). This translational trial provides important data on angiogenesis and other biomarkers on which to base future clinical research, which should include trials of green tea extract or polyphenols combined with other natural or synthetic compounds to enhance chemopreventive effects. The study and comment were published in November of 2009, so there should be further resarch being conducted that will be reported on in the future.
Catechins are polyphenolic compounds derived from green tea plant leaves (Camellia sinensis). They have been reported to have a wide range of biological activities including prevention of tooth decay, oral cancer and other diseases.
Halitosis
Bad breath. Green tea can wipe out the cause and symptoms. Bacteria in the mouth are responsible for the foul smell of halitosis. Polyphenols in the catechin class contained in green tea have anti-bacterial qualities and halt the biological reactions that make the smelly sulfur compounds. Green tea can both inhibit bacterial growth and alter the enzyme required to drive the production of hydrogen sulfide during protein digestion. The simple treatment for bad breath is to gargle with green tea.
Catechin Delivery to the Mouth
A study from 2004 tested the usefulness of green tea leaves to deliver catechins to the mouth.1
Subjects held 2 grams of green tea leaves in their mouths for 2-5 minutes and thoroughly rinsed their mouths. High concentrations of catechins were detected in saliva within the first hour of rinsing the mouth. The peak concentrations of catechins occurred between 25 and 44 minutes after rinsing. Researchers concluded that green tea leaves have potential for use in the prevention of oral cancer and dental caries by offering a convenient, slow-release source of catechins.
During a subsequent study on holding or chewing green tea leaves in the mouth the same scientists reported that catechin oxidation results in hydrogen peroxide as a by-product of the reaction.2 Human volunteers held green tea solution at a strength ranging from 0.1% to 0.6%. On another day the volunteers chewed 2 grams of green tea leaves. The hydrogen peroxide produced when leaves were chewed was more than when green tea solution was held in the mouth. The scientists concluded that catechin-generated hydrogen peroxide may have a significant role in disease prevention by green tea.
Green Tea and Oral Cancer Prevention
A short-term study was conducted on patients with oral premalignant lesions.3 Treatments of green tea extract was randomly assigned at doses of 500, 750 or 1000 mg/m2 or placebo three times a day for 12 weeks. The response rate to green tea extract was higher than to the placebo at all dosage rates but none of the responses were statistically significant. Even so, the two highest dosage treatments had higher responses which could be there was a dose-response effect.
The researchers concluded that the green tea extract was well tolerated at low treatment rates but at higher rates reports of insomnia and/or nervousness were made. No toxicity effect was realized. As for treatment efficacy, researchers suggested that higher doses of green tea extract in 12-week trials may improve response rates. However, the results support longer-term clinical testing of green tea extract for oral cancer prevention.
The results of this study are significant, according to Dong M. Shin at Emory University in Georgia.4 Green tea extract was shown for the first time to have dose-dependent effects in a clinical chemopreventive setting (oral premalignant lesions). This translational trial provides important data on angiogenesis and other biomarkers on which to base future clinical research, which should include trials of green tea extract or polyphenols combined with other natural or synthetic compounds to enhance chemopreventive effects. The study and comment were published in November of 2009, so there should be further resarch being conducted that will be reported on in the future.
