• Tuesday, December 10, 2019

Indian scientists discover insulin pills for diabetics

Discussion in 'World Affairs' started by KRAIT, Dec 19, 2013.

  1. KRAIT

    KRAIT ELITE MEMBER

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    LONDON: In a big breakthrough, Indian scientists have done what medical science has been trying to achieve since 1930 - an insulin pill for diabetics.

    Since insulin's crucial discovery nearly a century ago, countless diabetes patients have had to inject themselves with the life-saving medicine.

    Now Indian scientists have reported a new development toward a long-sought insulin pill that could save millions the pain of daily shots.
    Published in the American Chemical Society journa
    l, the advance could someday not only eliminate the "ouch" factor but also get needle-wary — and weary — patients to take their medicine when they should.

    For years, researchers have sought a way to transform delivery of this therapy from a shot to a pill, but it has been a challenge.

    The body's digestive enzymes that are so good at breaking down food also break down insulin before it can get to work.

    In addition, insulin doesn't get easily absorbed through the gut into the bloodstream.

    To overcome these hurdles, Sanyog Jain from India's National Institute of Pharmaceutical Education and Research combined two approaches to shield insulin from the digestive enzymes and then get it into the blood.

    They packaged insulin in tiny sacs made of lipids, or fats called liposomes, which are already used in some treatments. Then, they wrapped the liposomes in layers of protective molecules called polyelectrolytes.

    To help these "layersomes" get absorbed into the bloodstream, they attached folic acid, a kind of vitamin B that has been shown to help transport liposomes across the intestinal wall into the blood.

    In rats, the delivery system lowered blood glucose levels almost as much as injected insulin, though the effects of the "layersomes" lasted longer than that of injected insulin.

    Diabetes inhibits the production or use of insulin, which is a hormone that helps blood glucose or blood sugar become absorbed into cells and give them energy.

    Diabetes is one of India's biggest health challenges. By 2030, India's diabetes burden is expected to cross the 100 million mark, against 87 million estimated earlier.

    Type 1 diabetes occurs when the body doesn't make enough insulin, and type 2 diabetes occurs when the body doesn't make or use insulin very well, causing glucose to remain in the blood, which can lead to serious problems.

    Libby Dowling, care advisor at Diabetes UK, said "Oral insulin could make a big difference to the lives of people with diabetes. Children, elderly people and those with a phobia of needles would benefit particularly if and when insulin capsules become a safe and effective treatment for the condition.

    Although more research is needed, Diabetes UK would very much like to see insulin capsules one day become a reality."

    She added, "Many people with Type 2 diabetes take diabetes tablets. They are not the same as insulin. As yet insulin cannot be taken in tablet form because it would be broken down in the stomach before it could work. Diabetes tablets work in different ways to lower blood glucose levels - for example by stimulating the pancreas to produce more insulin, or by helping the body to use the insulin that it does produce more effectively"

    Indian scientists discover insulin pills for diabetics - The Times of India
     
  2. rott

    rott SENIOR MEMBER

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    Good news for all.
     
  3. genghis khan

    genghis khan BANNED

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    Great Break through....:yahoo::yahoo: for diabetic patients
     
  4. trident2010

    trident2010 SENIOR MEMBER

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    Well done!!
     
  5. Robinhood Pandey

    Robinhood Pandey SENIOR MEMBER

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    :pleasantry: INDIA:pleasantry:
     
  6. Dash

    Dash SENIOR MEMBER

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    :sniper:@KRAIT ...You are fast man, I was going to post this..
     
  7. sincity

    sincity FULL MEMBER

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    Good job.
     
  8. kbd-raaf

    kbd-raaf SENIOR MEMBER

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    Good news, especially with India's high prevalence of diabetes :D
     
  9. Anubis

    Anubis SENIOR MEMBER

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    Need more details on the invention.....Insulin pills have existed since 1950s!
     
  10. KRAIT

    KRAIT ELITE MEMBER

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    Mind Reader and Controller. I delayed your response by brain waves. :devil:
     
  11. Rajput_Pakistani

    Rajput_Pakistani FULL MEMBER

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    Sorry to burst your bubble, but oral insulin is already discovered and commercially available.

    Here is the link to one of the company marketing Insulin Capsule

    ORMD 0801 - Oral Insulin Capsule - Oramed
     
  12. rohitP

    rohitP BANNED

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    India is the best. So glad to see our country slowly making its mark in scientific field as well.

    :yay:
     
  13. KRAIT

    KRAIT ELITE MEMBER

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    Go and tell it to American Chemical Society Journal.

    Also, look at the way diabetes pills work.

    Re-read the article and if you still don't understand it, burst the bubble again, and I will splash your brain in layman's terms. :D
     
  14. thesolar65

    thesolar65 SENIOR MEMBER

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    Great news for me!! Hope it comes to market soon.
     
  15. Beidou2020

    Beidou2020 SENIOR MEMBER

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    no they didn't.